- Small Molecule Antagonist of Leukocyte Function Associated Antigen-1 (LFA-1): Structure-Activity Relationships Leading to the Identification of 6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic Acid (BMS-688521)
[作者:WATTERSON SCOTT H; XIAO ZILI; DODD DHARMPAL S; TORTOLANI DAVID R; VACCARO WAYNE; POTIN DOMINIQUE; LAUNAY MICHELE; STETSKO DAWN K; SKALA STACEY; DAVIS PATRIC M; LEE DEBORAH; YANG XIAOXIA; MCINTYRE KIM W; BALIMANE PRAVEEN; PATEL KARISHMA; YANG ZHENG; MARATHE PUNK; KADIYALA PATHANJALI; TEBBEN ANDREW J; SHERIFF STEVEN; CHANG CHIEHYING Y; ZIEMBA THERESA; ZHANG HUIPING; CHEN BANGCHI; DELMONTE ALBERT J; ARANIBAR NELLY; MCKINNON MURRAY; BARRISH JOEL C; SUCHARD SUZANNE J; DHAR T G MURALI,期刊:Journal of Medicinal Chemistry, 页码:3814-3830 , 文章类型: Article,,卷期:2010年53-9]
- Leukocyte function-associated antigen-1 (LFA-1), also known as CD11a/CD18 or alpha(L)beta(2), belongs to the beta(2) integrin subfamily and is constitutively expressed on all leukocytes. The major ligands of LFA-1 includ...
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