The title compound 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde was transformed into tricyclic heterocycles by substituting the chlorine atom by an unsaturated thiolate or alkoxide and then converting aldehyde function i...
Reaction of diacyl thiocarbohydrazides with dimethyl but-2-ynedioate in refluxing ethanol led to oxa-thiazolidine-5-ylidene-acetates in good yields. Reaction of the newly prepared N-(2-(propan-2-ylidene) hydrazine-carbon...
New macrocyclic polyether compounds containing a 2,5-bis(2-hydroxypheny1)-1,3,4-oxadiazole moiety are quickly prepared by a nucleophilic substitution reaction involving ethylene glycol ditosylate or polyethylene glycol d...
Novel substituted 2-hydrazino-pyrimidin-4(3H)-one derivatives were synthesized and examined for their antifolate activity against DHFR from Pneumocystis carinii (pc), Toxoplasma gondii (tg), Mycobacterium avium (ma), and...
Regio- and stereo-controlled opening of 2,3-epoxy amines and 2,3-aziridine amines by the commercially available MgBr2 is described. As reported, this new method could represent a general and useful approach for the prepa...
Anatabine is a major alkaloid in Nicotiana tabactum and its isomer, isoanatabine, was recently found in a marine worm. Reduction of I-methylpyridinium iodide with sodium borohydride gave 1-methyl-3-piperideine, which was...
Synthesis of some novel N-substituted 2-(chroman/6-bromochroman-2-yl)-1H-benzimidazoles by the condensation of 3,4-dihydro-2H-chroman-2-carboxylic acid and 6-bromo-3,4-dihydro-2H-chroman-2-carboxylic acid with o-phenylen...
Silica gel supported Phosphomolybdic acid (PMA.SiO2) catalyzes efficiently the one-pot three-component coupling reaction of anthranilic acid, orthoesters, and amines at room temperature to afford 4(3H)-Quinazolinones in ...
New Z-3-chloro-3-(4-chloro-6-methyl-2-oxo-2H-pyran-3-yl)acrolein was synthesized starting from dehydroacetic acid using Vilsmeier-Haack reaction and efficiently used in three component direct Mannich-type reaction with d...