- Sulindac confers high level ischemic protection to the heart through late preconditioning mechanisms
[作者:Moench, I; Prentice, H; Rickaway, Z; Weissbach, H,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19611-19616 , 文章类型: Article,,卷期:2009年106-46]
- We have recently shown that sulindac, an anti-inflammatory drug, enhances the killing of cancer cells, but not normal cells, under conditions of oxidative stress, by mechanisms unrelated to its cyclooxygenase (COX) inhib...
- The physical state of water in bacterial spores
[作者:Sunde, EP; Setlow, P; Hederstedt, L; Halle, B,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19334-19339 , 文章类型: Article,,卷期:2009年106-46]
- The bacterial spore, the hardiest known life form, can survive in a metabolically dormant state for many years and can withstand high temperatures, radiation, and toxic chemicals. The molecular basis of spore dormancy an...
- Single-molecule denaturation and degradation of proteins by the AAA plus ClpXP protease
[作者:Shin, Y; Davis, JH; Brau, RR; Martin, A; Kenniston, JA; Baker, TA; Sauer, RT; Lang, MJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19340-19345 , 文章类型: Article,,卷期:2009年106-46]
- ClpXP is an ATP-fueled molecular machine that unfolds and degrades target proteins. ClpX, an AAA+ enzyme, recognizes specific proteins, and then uses cycles of ATP hydrolysis to denature any native structure and to trans...
- Deletion of Drosophila insulin-like peptides causes growth defects and metabolic abnormalities
[作者:Zhang, H; Liu, JN; Li, CR; Momen, B; Kohanski, RA; Pick, L,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19617-19622 , 文章类型: Article,,卷期:2009年106-46]
- Insulin/Insulin-like growth factor signaling regulates homeostasis and growth in mammals, and is implicated in diseases from diabetes to cancer. In Drosophila melanogaster, as in other invertebrates, multiple Insulin-Lik...
- Plasticity in Ca2+ selectivity of Orai1/Orai3 heteromeric channel
[作者:Schindl, R; Frischauf, I; Bergsmann, J; Muik, M; Derler, I; Lackner, B; Groschner, K; Romanin, C,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19623-19628 , 文章类型: Article,,卷期:2009年106-46]
- A general cellular response following depletion of intracellular calcium stores involves activation of store-operated channels (SOCs). While Orai1 forms the native Ca2+ release-activated Ca2+ (CRAC) channel in mast and T...
- Parameters that influence the prediction of epidemiological benefits of more-effective tuberculosis vaccines, drugs, and diagnosis
[作者:Vani, J; Maddur, MS; Lacroix-Desmazes, S; Kaveri, SV; Bayry, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E129-E129 , 文章类型: Letter,,卷期:2009年106-46]
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- Reply to Vani et al.: Tuberculosis models and complexity
[作者:Halloran, ME; Achterberg, JT; Sabatelli, L; Sugimoto, JD; Dye, C; Longini, IM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E130-E130 , 文章类型: Letter,,卷期:2009年106-46]
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- Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat
[作者:Seluanov, A; Hine, C; Azpurua, J; Feigenson, M; Bozzella, M; Mao, ZY; Catania, KC; Gorbunova, V,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19352-19357 , 文章类型: Article,,卷期:2009年106-46]
- The naked mole-rat is the longest living rodent with a maximum lifespan exceeding 28 years. In addition to its longevity, naked mole-rats have an extraordinary resistance to cancer as tumors have never been observed in t...
- STIM1-induced precortical and cortical subdomains of the endoplasmic reticulum
[作者:Orci, L; Ravazzola, M; Le Coadic, M; Shen, WW; Demaurex, N; Cosson, P,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19358-19362 , 文章类型: Article,,卷期:2009年106-46]
- Store-operated calcium entry relies on the formation of a specialized compartment derived from the endoplasmic reticulum (ER) and closely apposed to the plasma membrane. In this study, detailed ultrastructural analysis r...
- G9a selectively represses a class of late-replicating genes at the nuclear periphery
[作者:Yokochi, T; Poduch, K; Ryba, T; Lu, JJ; Hiratani, I; Tachibana, M; Shinkai, Y; Gilbert, DM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19363-19368 , 文章类型: Article,,卷期:2009年106-46]
- We have investigated the role of the histone methyltransferase G9a in the establishment of silent nuclear compartments. Following conditional knockout of the G9a methyltransferase in mouse ESCs, 167 genes were significan...
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