- Long-term economic growth stimulus of human capital preservation in the elderly
[作者:Manton, KG; Gu, XL; Ullian, A; Tolley, HD; Headen, AE; Lowrimore, G,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21080-21085 , 文章类型: Article,,卷期:2009年106-50]
- Health care is a crucial factor in US economic growth, because growing health care costs have made US corporations less competitive than their counterparts in countries where central governments assume most of those cost...
- Eye movement evidence that readers maintain and act on uncertainty about past linguistic input
[作者:Levy, R; Bicknell, K; Slattery, T; Rayner, K,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21086-21090 , 文章类型: Article,,卷期:2009年106-50]
- In prevailing approaches to human sentence comprehension, the outcome of the word recognition process is assumed to be a categorical representation with no residual uncertainty. Yet perception is inevitably uncertain, an...
- NADP(+)-dependent farnesol dehydrogenase, a corpora allata enzyme involved in juvenile hormone synthesis
[作者:Mayoral, JG; Nouzova, M; Navare, A; Noriega, FG,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21091-21096 , 文章类型: Article,,卷期:2009年106-50]
- The synthesis of juvenile hormone (JH) is an attractive target for control of insect pests and vectors of disease, but the minute size of the corpora allata (CA), the glands that synthesize JH, has made it difficult to i...
- The transmembrane inner ear (Tmie) protein is essential for normal hearing and balance in the zebrafish
[作者:Gleason, MR; Nagiel, A; Jamet, S; Vologodskaia, M; Lopez-Schier, H; Hudspeth, AJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21347-21352 , 文章类型: Article,,卷期:2009年106-50]
- Little is known about the proteins that mediate mechanoelectrical transduction, the process by which acoustic and accelerational stimuli are transformed by hair cells of the inner ear into electrical signals. In our sear...
- PKC delta regulates cortical radial migration by stabilizing the Cdk5 activator p35
[作者:Zhao, CT; Li, K; Li, JT; Zheng, W; Liang, XJ; Geng, AQ; Li, N; Yuan, XB,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21353-21358 , 文章类型: Article,,卷期:2009年106-50]
- Cyclin-dependent kinase 5 (Cdk5) and its activator p35 are critical for radial migration and lamination of cortical neurons. However, how this kinase is regulated by extracellular and intracellular signals during cortica...
- The nuclear receptor ROR alpha exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes
[作者:Journiac, N; Jolly, S; Jarvis, C; Gautheron, V; Rogard, M; Trembleau, A; Blondeau, JP; Mariani, J; Vernet-der Garabedian, B,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21365-21370 , 文章类型: Article,,卷期:2009年106-50]
- Astrocytes and one of their products, IL-6, not only support neurons but also mediate inflammation in the brain. Retinoid-related orphan receptor-alpha (ROR alpha) transcription factor has related roles, being neuro-prot...
- The appearance of pyrrolysine in tRNA(His) guanylyltransferase by neutral evolution
[作者:Heinemann, IU; O'Donoghue, P; Madinger, C; Benner, J; Randau, L; Noren, CJ; Soll, D,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21103-21108 , 文章类型: Article,,卷期:2009年106-50]
- tRNA(His) guanylyltransferase (Thg1) post-transcriptionally adds a G (position -1) to the 5'-terminus of tRNA(His). The Methanosarcina acetivorans Thg1 (MaThg1) gene contains an in-frame TAG (amber) codon. Although a UAG...
- Calcium signaling cascade links dopamine D1-D2 receptor heteromer to striatal BDNF production and neuronal growth
[作者:Hasbi, A; Fan, T; Alijaniaram, M; Nguyen, T; Perreault, ML; O'Dowd, BF; George, SR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21377-21382 , 文章类型: Article,,卷期:2009年106-50]
- Although the perturbation of either the dopaminergic system or brain-derived neurotrophic factor (BDNF) levels has been linked to important neurological and neuropsychiatric disorders, there is no known signaling pathway...
- SCAP is required for timely and proper myelin membrane synthesis
[作者:Verheijen, MHG; Camargo, N; Verdier, V; Nadra, K; Charles, ASD; Medard, JJ; Luoma, A; Crowther, M; Inouye, H; Shimano, H; Chen, S; Brouwers, JF; Helms, JB; Feltri, ML; Wrabetz, L; Kirschner, D; Chrast, R; Smit, AB,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21383-21388 , 文章类型: Article,,卷期:2009年106-50]
- Myelination requires a massive increase in glial cell membrane synthesis. Here, we demonstrate that the acute phase of myelin lipid synthesis is regulated by sterol regulatory element-binding protein (SREBP) cleavage act...
- The structure of a DnaA/HobA complex from Helicobacter pylori provides insight into regulation of DNA replication in bacteria
[作者:Natrajan, G; Noirot-Gros, MF; Zawilak-Pawlik, A; Kapp, U; Terradot, L,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21115-21120 , 文章类型: Article,,卷期:2009年106-50]
- Bacterial DNA replication requires DnaA, an AAA+ ATPase that initiates replication at a specific chromosome region, oriC, and is regulated by species-specific regulators that directly bind DnaA. HobA is a DnaA binding pr...
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