- A Promiscuous Conformational Switch in the Secondary Multidrug Transporter MdfA
[作者:Fluman, N; Cohen-Karni, D; Weiss, T; Bibi, E,期刊:Journal of Biological Chemistry, 页码:32296-32304 , 文章类型: Article,,卷期:2009年284-47]
- Multidrug (Mdr) transporters are membrane proteins that actively export structurally dissimilar drugs from the cell, thereby rendering the cell resistant to toxic compounds. Similar to substrate-specific transporters, Md...
- Phosphoglucose Isomerase/Autocrine Motility Factor Promotes Melanoma Cell Migration through ERK Activation Dependent on Autocrine Production of Interleukin-8
[作者:Araki, K; Shimura, T; Yajima, T; Tsutsumi, S; Suzuki, H; Okada, K; Kobayashi, T; Raz, A; Kuwano, H,期刊:Journal of Biological Chemistry, 页码:32305-32311 , 文章类型: Article,,卷期:2009年284-47]
- It is well known that phosphoglucose isomerase/autocrine motility factor (AMF) promotes cell migration in an autocrine manner in various tumor cells. However, it remains unclear whether certain cytokines modulate the eff...
- Two Lysine Residues in the Bacterial Luciferase Mobile Loop Stabilize Reaction Intermediates
[作者:Campbell, ZT; Baldwin, TO,期刊:Journal of Biological Chemistry, 页码:32827-32834 , 文章类型: Article,,卷期:2009年284-47]
- Bacterial luciferase catalyzes the reaction of FMNH2, O-2, and a long chain aliphatic aldehyde, yielding FMN, carboxylic acid, and blue-green light. The most conserved contiguous region of the primary sequence correspond...
- A Bifunctional Intronic Element Regulates the Expression of the Arginine/Lysine Transporter Cat-1 via Mechanisms Involving the Purine-rich Element Binding Protein A (Pur alpha)
[作者:Huang, CC; Chiribau, CB; Majumder, M; Chiang, CM; Wek, RC; Kelm, RJ; Khalili, K; Snider, MD; Hatzoglou, M,期刊:Journal of Biological Chemistry, 页码:32312-32320 , 文章类型: Article,,卷期:2009年284-47]
- Expression of the arginine/lysine transporter Cat-1 is highly induced in proliferating and stressed cells via mechanisms that include transcriptional activation. A bifunctional INE (intronic element) within the first int...
- Saccharomyces CDK1 Phosphorylates Rad53 Kinase in Metaphase, Influencing Cellular Morphogenesis
[作者:Diani, L; Colombelli, C; Nachimuthu, BT; Donnianni, R; Plevani, P; Muzi-Falconi, M; Pellicioli, A,期刊:Journal of Biological Chemistry, 页码:32627-32634 , 文章类型: Article,,卷期:2009年284-47]
- Rad53 is an essential protein kinase governing DNA damage and replication stress checkpoints in budding yeast. It also appears to be involved in cellular morphogenesis processes. Mass spectrometry analyses revealed that ...
- A Mycobacterial Cyclic AMP Phosphodiesterase That Moonlights as a Modifier of Cell Wall Permeability
[作者:Podobnik, M; Tyagi, R; Matange, N; Dermol, U; Gupta, AK; Mattoo, R; Seshadri, K; Visweswariah, SS,期刊:Journal of Biological Chemistry, 页码:32846-32857 , 文章类型: Article,,卷期:2009年284-47]
- Mycobacterium tuberculosis utilizes many mechanisms to establish itself within the macrophage, and bacterially derived cAMP is important in modulating the host cellular response. Although the genome of M. tuberculosis is...
- The ATPase Cycle of the Mitotic Motor CENP-E
[作者:Rosenfeld, SS; van Duffelen, M; Behnke-Parks, WM; Beadle, C; Corrreia, J; Xing, J,期刊:Journal of Biological Chemistry, 页码:32858-32868 , 文章类型: Article,,卷期:2009年284-47]
- We have previously shown that the mitotic motor centrosome protein E (CENP-E) is capable of walking for more than 250 steps on its microtubule track without dissociating. We have examined the kinetics of this molecular m...
- The Kruppel-like Zinc Finger Protein ZNF224 Recruits the Arginine Methyltransferase PRMT5 on the Transcriptional Repressor Complex of the Aldolase A Gene
[作者:Cesaro, E; De Cegli, R; Medugno, L; Florio, F; Grosso, M; Lupo, A; Izzo, P; Costanzo, P,期刊:Journal of Biological Chemistry, 页码:32321-32330 , 文章类型: Article,,卷期:2009年284-47]
- Gene transcription in eukaryotes is modulated by the coordinated recruitment of specific transcription factors and chromatin-modulating proteins. Indeed, gene activation and/or repression is/are regulated by histone meth...
- Transcriptional Regulation of Mouse Mast Cell Protease-2 by Interleukin-15
[作者:Mirghomizadeh, F; Bullwinkel, J; Orinska, Z; Janssen, O; Petersen, A; Singh, PB; Bulfone-Paus, S,期刊:Journal of Biological Chemistry, 页码:32635-32641 , 文章类型: Article,,卷期:2009年284-47]
- Mast cells (MCs) play a critical role in innate and adaptive immunity through the release of cytokines, chemokines, lipid mediators, biogenic amines, and proteases. We recently showed that the activities of MC proteases ...
- D-AKAP2 Interacts with Rab4 and Rab11 through Its RGS Domains and Regulates Transferrin Receptor Recycling
[作者:Eggers, CT; Schafer, JC; Goldenring, JR; Taylor, SS,期刊:Journal of Biological Chemistry, 页码:32869-32880 , 文章类型: Article,,卷期:2009年284-47]
- Dual-specific A-kinase-anchoring protein 2 (D-AKAP2/AKAP10), which interacts at its carboxyl terminus with protein kinase A and PDZ domain proteins, contains two tandem regulator of G-protein signaling (RGS) domains for ...
- Control of Respiration by Cytochrome c Oxidase in Intact Cells ROLE OF THE MEMBRANE POTENTIAL
[作者:Dalmonte, ME; Forte, E; Genova, ML; Giuffre, A; Sarti, P; Lenaz, G,期刊:Journal of Biological Chemistry, 页码:32331-32335 , 文章类型: Article,,卷期:2009年284-47]
- Metabolic control analysis was applied to intact HepG2 cells. The effect on the control coefficient of cytochrome c oxidase (CcOX) over cell respiration of both the electrical (Delta psi) and chemical (Delta pH) componen...
- The Macrophage Cholesterol Exporter ABCA1 Functions as an Anti-inflammatory Receptor
[作者:Tang, CR; Liu, YH; Kessler, PS; Vaughan, AM; Oram, JF,期刊:Journal of Biological Chemistry, 页码:32336-32343 , 文章类型: Article,,卷期:2009年284-47]
- ATP-binding cassette transporter A1 (ABCA1) is a cell membrane protein that exports excess cholesterol from cells to apolipoprotein (apo) A-I, the major protein in high density lipoproteins. Genetic studies have shown th...
- Interactions between EB1 and Microtubules DRAMATIC EFFECT OF AFFINITY TAGS AND EVIDENCE FOR COOPERATIVE BEHAVIOR
[作者:Zhu, ZQC; Gupta, KK; Slabbekoorn, AR; Paulson, BA; Folker, ES; Goodson, HV,期刊:Journal of Biological Chemistry, 页码:32651-32661 , 文章类型: Article,,卷期:2009年284-47]
- Plus end tracking proteins (+TIPs) are a unique group of microtubule binding proteins that dynamically track microtubule (MT) plus ends. EB1 is a highly conserved +TIP with a fundamental role in MT dynamics, but it remai...
- Elevation of Glutamine Level by Selenophosphate Synthetase 1 Knockdown Induces Megamitochondrial Formation in Drosophila Cells
[作者:Shim, MS; Kim, JY; Jung, HK; Lee, KH; Xu, XM; Carlson, BA; Kim, KW; Kim, IY; Hatfield, DL; Lee, BJ,期刊:Journal of Biological Chemistry, 页码:32881-32894 , 文章类型: Article,,卷期:2009年284-47]
- Although selenophosphate synthetase 1 (SPS1/SelD) is an essential gene in Drosophila, its function has not been determined. To elucidate its intracellular role, we targeted the removal of SPS1/SelD mRNA in Drosophila SL2...
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