- Fibril Fragmentation Enhances Amyloid Cytotoxicity
[作者：Xue, WF; Hellewell, AL; Gosal, WS; Homans, SW; Hewitt, EW; Radford, SE,期刊：Journal of Biological Chemistry, 页码：34272-34282 , 文章类型： Article，,卷期：2009年284-49]
- Fibrils associated with amyloid disease are molecular assemblies of key biological importance, yet how cells respond to the presence of amyloid remains unclear. Cellular responses may not only depend on the chemical comp...
- Mediator of DNA Damage Checkpoint 1 (MDC1) Regulates Mitotic Progression
[作者：Townsend, K; Mason, H; Blackford, AN; Miller, ES; Chapman, JR; Sedgwick, GG; Barone, G; Turnell, AS; Stewart, GS,期刊：Journal of Biological Chemistry, 页码：33939-33948 , 文章类型： Article，,卷期：2009年284-49]
- Human mediator of DNA damage checkpoint 1 (hMDC1) is an essential component of the cellular response to DNA double strand breaks. Recently, hMDC1 has been shown to associate with a subunit of the anaphase-promoting compl...
- A Role for the ATP7A Copper-transporting ATPase in Macrophage Bactericidal Activity
[作者：White, C; Lee, J; Kambe, T; Fritsche, K; Petris, MJ,期刊：Journal of Biological Chemistry, 页码：33949-33956 , 文章类型： Article，,卷期：2009年284-49]
- Copper is an essential micronutrient that is necessary for healthy immune function. This requirement is underscored by an increased susceptibility to bacterial infection in copper-deficient animals; however, a molecular ...
- The Target of the NSD Family of Histone Lysine Methyltransferases Depends on the Nature of the Substrate
[作者：Li, Y; Trojer, P; Xu, CF; Cheung, P; Kuo, A; Drury, WJ; Qiao, Q; Neubert, TA; Xu, RM; Gozani, O; Reinberg, D,期刊：Journal of Biological Chemistry, 页码：34283-34295 , 文章类型： Article，,卷期：2009年284-49]
- The NSD (nuclear receptor SET domain-containing) family of histone lysine methyltransferases is a critical participant in chromatin integrity as evidenced by the number of human diseases associated with the aberrant expr...
- Tyrosine Phosphorylation of 3BP2 Regulates B Cell Receptor-mediated Activation of NFAT
[作者：Shukla, U; Hatani, T; Nakashima, K; Ogi, K; Sada, K,期刊：Journal of Biological Chemistry, 页码：33719-33728 , 文章类型： Article，,卷期：2009年284-49]
- Adaptor protein c-Abl SH3 domain-binding protein-2 (3BP2, also referred to SH3BP2) regulates immune receptor-mediated signal transduction. In this report we focused on the molecular mechanism of 3BP2 function in B cell r...
- Purification and Reconstitution of the Antigen Transport Complex TAP A PREREQUISITE FOR DETERMINATION OF PEPTIDE STOICHIOMETRY AND ATP HYDROLYSIS
[作者：Herget, M; Kreissig, N; Kolbe, C; Scholz, C; Tampe, R; Abele, R,期刊：Journal of Biological Chemistry, 页码：33740-33749 , 文章类型： Article，,卷期：2009年284-49]
- The transporter associated with antigen processing (TAP) is an essential machine of the adaptive immune system that translocates antigenic peptides from the cytosol into the endoplasmic reticulum lumen for loading of maj...
- Translocation and Endocytosis for Cell-penetrating Peptide Internalization
[作者：Jiao, CY; Delaroche, D; Burlina, F; Alves, ID; Chassaing, G; Sagan, S,期刊：Journal of Biological Chemistry, 页码：33957-33965 , 文章类型： Article，,卷期：2009年284-49]
- Cell-penetrating peptides (CPPs) share the property of cellular internalization. The question of how these peptides reach the cytoplasm of cells is still widely debated. Herein, we have used a mass spectrometry-based met...
- alpha v beta 3 Integrin Limits the Contribution of Neuropilin-1 to Vascular Endothelial Growth Factor-induced Angiogenesis
[作者：Robinson, SD; Reynolds, LE; Kostourou, V; Reynolds, AR; da Silva, RG; Tavora, B; Baker, M; Marshall, JF; Hodivala-Dilke, KM,期刊：Journal of Biological Chemistry, 页码：33966-33981 , 文章类型： Article，,卷期：2009年284-49]
- Both vascular endothelial growth factor receptors (VEGFR) and integrins are major regulators of VEGF-induced angiogenesis. Previous work has shown that beta 3 integrin can regulate negatively VEGFR2 expression. Here we s...
- MAPK Pathway Activation Delays G(2)/M Progression by Destabilizing Cdc25B
[作者：Astuti, P; Pike, T; Widberg, C; Payne, E; Harding, A; Hancock, J; Gabrielli, B,期刊：Journal of Biological Chemistry, 页码：33781-33788 , 文章类型： Article，,卷期：2009年284-49]
- Activation of the mitogen-activated protein kinase (MAPK) pathway by growth factors or phorbol esters during G(2) phase delays entry into mitosis; however, the role of the MAPK pathway during G(2)/M progression remains c...
- Phosphorylation of Myocardin by Extracellular Signal-regulated Kinase
[作者：Taurin, S; Sandbo, N; Yau, DM; Sethakorn, N; Kach, J; Dulin, NO,期刊：Journal of Biological Chemistry, 页码：33789-33794 , 文章类型： Article，,卷期：2009年284-49]
- The contractile phenotype of smooth muscle (SM) cells is controlled by serum response factor (SRF), which drives the expression of SM-specific genes including SM alpha-actin, SM22, and others. Myocardin is a cardiac and ...
- Cyclophilin D Modulates Mitochondrial F0F1-ATP Synthase by Interacting with the Lateral Stalk of the Complex
[作者：Giorgio, V; Bisetto, E; Soriano, ME; Dabbeni-Sala, F; Basso, E; Petronilli, V; Forte, MA; Bernardi, P; Lippe, G,期刊：Journal of Biological Chemistry, 页码：33982-33988 , 文章类型： Article，,卷期：2009年284-49]
- Blue native gel electrophoresis purification and immunoprecipitation of F0F1-ATP synthase from bovine heart mitochondria revealed that cyclophilin (CyP) D associates to the complex. Treatment of intact mitochondria with ...
- Mechanism for Amyloid Precursor-like Protein 2 Enhancement of Major Histocompatibility Complex Class I Molecule Degradation
[作者：Tuli, A; Sharma, M; Capek, HL; Naslavsky, N; Caplan, S; Solheim, JC,期刊：Journal of Biological Chemistry, 页码：34296-34307 , 文章类型： Article，,卷期：2009年284-49]
- Earlier studies have demonstrated interaction of the murine major histocompatibility complex (MHC) class I molecule K-d with amyloid precursor-like protein 2 (APLP2), a ubiquitously expressed member of the amyloid precur...
- Structural Snapshots of Heparin Depolymerization by Heparin Lyase I
[作者：Han, YH; Garron, ML; Kim, HY; Kim, WS; Zhang, ZQ; Ryu, KS; Shaya, D; Xiao, ZP; Cheong, C; Kim, YS; Linhardt, RJ; Jeon, YH; Cygler, M,期刊：Journal of Biological Chemistry, 页码：34019-34027 , 文章类型： Article，,卷期：2009年284-49]
- Heparin lyase I (heparinase I) specifically depolymerizes heparin, cleaving the glycosidic linkage next to iduronic acid. Here, we show the crystal structures of heparinase I from Bacteroides thetaiotaomicron at various ...
- Predictive Computational Models of Substrate Binding by a Nucleoside Transporter
[作者：Collar, CJ; Al-Salabi, MI; Stewart, ML; Barrett, MP; Wilson, WD; de Koning, HP,期刊：Journal of Biological Chemistry, 页码：34028-34035 , 文章类型： Article，,卷期：2009年284-49]
- Transporters play a vital role in both the resistance mechanisms of existing drugs and effective targeting of their replacements. Melarsoprol and diamidine compounds similar to pentamidine and furamidine are primarily ta...
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