- Bestrophin-1 Enables Ca2+-activated Cl- Conductance in Epithelia
[作者:Soria, RB; Spitzner, M; Schreiber, R; Kunzelmann, K,期刊:Journal of Biological Chemistry, 页码:29405-29412 , 文章类型: Article,,卷期:2009年284-43]
- Epithelial cells express calcium-activated Cl- channels of unknown molecular identity. These Cl- channels play a central role in diseases such as secretory diarrhea, polycystic kidney disease, and cystic fibrosis. The fa...
- Phosphorylation of Threonine 3 IMPLICATIONS FOR HUNTINGTIN AGGREGATION AND NEUROTOXICITY
[作者:Aiken, CT; Steffan, JS; Guerrero, CM; Khashwji, H; Lukacsovich, T; Simmons, D; Purcell, JM; Menhaji, K; Zhu, YZ; Green, K; LaFerla, F; Huang, L; Thompson, LM; Marsh, JL,期刊:Journal of Biological Chemistry, 页码:29427-29436 , 文章类型: Article,,卷期:2009年284-43]
- Huntingtin (Htt) is a widely expressed protein that causes tissue-specific degeneration when mutated to contain an expanded polyglutamine (poly(Q)) domain. Although Htt is large, 350 kDa, the appearance of amino-terminal...
- Structure of an Arrestin2-Clathrin Complex Reveals a Novel Clathrin Binding Domain That Modulates Receptor Trafficking
[作者:Kang, DS; Kern, RC; Puthenveedu, MA; von Zastrow, M; Williams, JC; Benovic, JL,期刊:Journal of Biological Chemistry, 页码:29860-29872 , 文章类型: Article,,卷期:2009年284-43]
- Non-visual arrestins play a pivotal role as adaptor proteins in regulating the signaling and trafficking of multiple classes of receptors. Although arrestin interaction with clathrin, AP-2, and phosphoinositides contribu...
- Mammalian Formin Fhod3 Regulates Actin Assembly and Sarcomere Organization in Striated Muscles
[作者:Taniguchi, K; Takeya, R; Suetsugu, S; Kan-o, M; Narusawa, M; Shiose, A; Tominaga, R; Sumimoto, H,期刊:Journal of Biological Chemistry, 页码:29873-29881 , 文章类型: Article,,卷期:2009年284-43]
- Actin filament assembly in nonmuscle cells is regulated by the actin polymerization machinery, including the Arp2/3 complex and formins. However, little is known about the regulation of actin assembly in muscle cells, wh...
- Matricellular Protein CCN3 (NOV) Regulates Actin Cytoskeleton Reorganization
[作者:Sin, WC; Tse, M; Planque, N; Perbal, B; Lampe, PD; Naus, CC,期刊:Journal of Biological Chemistry, 页码:29935-29944 , 文章类型: Article,,卷期:2009年284-43]
- CCN3 (NOV), a putative ligand for integrin receptors, is tightly associated with the extracellular matrix and mediates diverse cellular functions, including cell adhesion and proliferation. CCN3 has been shown to negativ...
- A Novel Class of Cyclin-dependent Kinase Inhibitors Identified by Molecular Docking Act through a Unique Mechanism
[作者:Corsino, P; Horenstein, N; Ostrov, D; Rowe, T; Law, M; Barrett, A; Aslanidi, G; Cress, WD; Law, B,期刊:Journal of Biological Chemistry, 页码:29945-29955 , 文章类型: Article,,卷期:2009年284-43]
- The cyclin-dependent kinase (Cdk) family is emerging as an important therapeutic target in the treatment of cancer. Cdks 1, 2, 4, and 6 are the key members that regulate the cell cycle, as opposed to Cdks that control pr...
- Acetylation of Transition Protein 2 (TP2) by KAT3B (p300) Alters Its DNA Condensation Property and Interaction with Putative Histone Chaperone NPM3
[作者:Pradeepa, MM; Nikhil, G; Kishore, AH; Bharath, GN; Kundu, TK; Rao, MRS,期刊:Journal of Biological Chemistry, 页码:29956-29967 , 文章类型: Article,,卷期:2009年284-43]
- The hallmark of mammalian spermiogenesis is the dramatic chromatin remodeling process wherein the nucleosomal histones are replaced by the transition proteins TP1, TP2, and TP4. Subsequently these transition proteins are...
- JNK/FOXO-mediated Neuronal Expression of Fly Homologue of Peroxiredoxin II Reduces Oxidative Stress and Extends Life Span
[作者:Lee, KS; Iijima-Ando, K; Iijima, K; Lee, WJ; Lee, JH; Yu, K; Lee, DS,期刊:Journal of Biological Chemistry, 页码:29454-29461 , 文章类型: Article,,卷期:2009年284-43]
- Activation of c-Jun N-terminal kinase (JNK) signaling in neurons increases stress resistance and extends life span, in part through FOXO-mediated transcription in Drosophila. However, the JNK/FOXO target genes are unknow...
- A cis-Proline in alpha-Hemoglobin Stabilizing Protein Directs the Structural Reorganization of alpha-Hemoglobin
[作者:Gell, DA; Feng, L; Zhou, SP; Jeffrey, PD; Bendak, K; Gow, A; Weiss, MJ; Shi, YG; Mackay, JP,期刊:Journal of Biological Chemistry, 页码:29462-29469 , 文章类型: Article,,卷期:2009年284-43]
- alpha-Hemoglobin (alpha Hb) stabilizing protein (AHSP) is expressed in erythropoietic tissues as an accessory factor in hemoglobin synthesis. AHSP forms a specific complex with alpha Hb and suppresses the heme-catalyzed ...
- Deletion of the Chloride Transporter Slc26a7 Causes Distal Renal Tubular Acidosis and Impairs Gastric Acid Secretion
[作者:Xu, J; Song, PH; Nakamura, S; Miller, M; Barone, S; Alper, SL; Riederer, B; Bonhagen, J; Arend, LJ; Amlal, H; Seidler, U; Soleimani, M,期刊:Journal of Biological Chemistry, 页码:29470-29479 , 文章类型: Article,,卷期:2009年284-43]
- SLC26A7 (human)/Slc26a7 (mouse) is a recently identified chloride-base exchanger and/or chloride transporter that is expressed on the basolateral membrane of acid-secreting cells in the renal outer medullary collecting d...
- New Structural Arrangement of the Extracellular Regions of the Phosphate Transporter SLC20A1, the Receptor for Gibbon Ape Leukemia Virus
[作者:Farrell, KB; Tusnady, GE; Eiden, MV,期刊:Journal of Biological Chemistry, 页码:29979-29987 , 文章类型: Article,,卷期:2009年284-43]
- Infection of a host cell by a retrovirus requires an initial interaction with a cellular receptor. For numerous gammaretroviruses, such as the gibbon ape leukemia virus, woolly monkey virus, feline leukemia virus subgrou...
- Transforming Growth Factors beta Coordinate Cartilage and Tendon Differentiation in the Developing Limb Mesenchyme
[作者:Lorda-Diez, CI; Montero, JA; Martinez-Cue, C; Garcia-Porrero, JA; Hurle, JM,期刊:Journal of Biological Chemistry, 页码:29988-29996 , 文章类型: Article,,卷期:2009年284-43]
- Transforming growth factor beta (TGF beta) signaling has an increasing interest in regenerative medicine as a potential tool to repair cartilages, however the chondrogenic effect of this pathway in developing systems is ...
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