- Rescue of a Trafficking Defective Human Pacemaker Channel via a Novel Mechanism ROLES OF Src, Fyn, AND Yes TYROSINE KINASES
[作者:Lin, YC; Huang, JY; Kan, H; Frisbee, JC; Yu, HG,期刊:Journal of Biological Chemistry, 页码:30433-30440 , 文章类型: Article,,卷期:2009年284-44]
- Therapeutic strategies such as using channel blockers and reducing culture temperature have been used to rescue some long QT-associated voltage-gated potassium Kv trafficking defective mutant channels. A hyperpolarizatio...
- C-terminal Residues Regulate Localization and Function of the Antiapoptotic Protein Bfl-1
[作者:Brien, G; Debaud, AL; Robert, X; Oliver, L; Trescol-Biemont, MC; Cauquil, N; Geneste, O; Aghajari, N; Vallette, FM; Haser, R; Bonnefoy-Berard, N,期刊:Journal of Biological Chemistry, 页码:30257-30263 , 文章类型: Article,,卷期:2009年284-44]
- Unlike other antiapoptotic members of the Bcl-2 family, Bfl-1 does not contain a well defined C-terminal transmembrane domain, and whether the C-terminal tail of Bfl-1 functions as a membrane anchor is not yet clearly es...
- Uptake of Oxidized Low Density Lipoprotein by CD36 Occurs by an Actin-dependent Pathway Distinct from Macropinocytosis
[作者:Collins, RF; Touret, N; Kuwata, H; Tandon, NN; Grinstein, S; Trimble, WS,期刊:Journal of Biological Chemistry, 页码:30288-30297 , 文章类型: Article,,卷期:2009年284-44]
- The class B scavenger receptor CD36 has numerous ligands that include modified forms of low density lipoprotein, fibrillar amyloid, apoptotic cells, and Plasmodium falciparum-infected red blood cells, linking this molecu...
- C-terminal Phenylalanine of Bacteriophage T7 Single-stranded DNA-binding Protein Is Essential for Strand Displacement Synthesis by T7 DNA Polymerase at a Nick in DNA
[作者:Ghosh, S; Marintcheva, B; Takahashi, M; Richardson, CC,期刊:Journal of Biological Chemistry, 页码:30339-30349 , 文章类型: Article,,卷期:2009年284-44]
- Single-stranded DNA-binding protein (gp2.5), encoded by gene 2.5 of bacteriophage T7, plays an essential role in DNA replication. Not only does it remove impediments of secondary structure in the DNA, it also modulates t...
- Adipose Triglyceride Lipase Deficiency Causes Tissue-specific Changes in Insulin Signaling
[作者:Kienesberger, PC; Lee, D; Pulinilkunnil, T; Brenner, DS; Cai, LZ; Magnes, C; Koefeler, HC; Streith, IE; Rechberger, GN; Haemmerle, G; Flier, JS; Zechner, R; Kim, YB; Kershaw, EE,期刊:Journal of Biological Chemistry, 页码:30218-30229 , 文章类型: Article,,卷期:2009年284-44]
- Triacylglycerol accumulation in insulin target tissues is associated with insulin resistance. Paradoxically, mice with global targeted deletion of adipose triglyceride lipase (ATGL), the rate-limiting enzyme in triacylgl...
- Dominant-negative Effects of COL7A1 Mutations Can be Rescued by Controlled Overexpression of Normal Collagen VII
[作者:Fritsch, A; Spassov, S; Elfert, S; Schlosser, A; Gache, Y; Meneguzzi, G; Bruckner-Tuderman, L,期刊:Journal of Biological Chemistry, 页码:30248-30256 , 文章类型: Article,,卷期:2009年284-44]
- Dominant-negative interference by glycine substitution mutations in the COL7A1 gene causes dominant dystrophic epidermolysis bullosa (DDEB), a skin fragility disorder with mechanically induced blistering. Although qualit...
- Function of Histone Deacetylase 6 as a Cofactor of Nuclear Receptor Coregulator LCoR
[作者:Palijan, A; Fernandes, I; Bastien, Y; Tang, LQ; Verway, M; Kourelis, M; Tavera-Mendoza, LE; Li, Z; Bourdeau, V; Mader, S; Yang, XJ; White, JH,期刊:Journal of Biological Chemistry, 页码:30264-30274 , 文章类型: Article,,卷期:2009年284-44]
- Ligand-dependent corepressor LCoR was identified as a protein that interacts with the estrogen receptor alpha(ER alpha) ligand binding domain in a hormone-dependent manner. LCoR also interacts directly with histone deace...
- Ligand-dependent Corepressor LCoR Is an Attenuator of Progesterone-regulated Gene Expression
[作者:Palijan, A; Fernandes, I; Verway, M; Kourelis, M; Bastien, Y; Tavera-Mendoza, LE; Sacheli, A; Bourdeau, V; Mader, S; White, JH,期刊:Journal of Biological Chemistry, 页码:30275-30287 , 文章类型: Article,,卷期:2009年284-44]
- Ligand-dependent corepressor LCoR interacts with the progesterone receptor (PR) and estrogen receptor ER alpha in the presence of hormone. LCoR contains tandem N-terminal PXDLS motifs that recruit C-terminal-binding prot...
- Suppression of p38 MAPK and JNK via Akt-mediated Inhibition of Apoptosis Signal-regulating Kinase 1 Constitutes a Core Component of the beta-Cell Pro-survival Effects of Glucose-dependent Insulinotropic Polypeptide
[作者:Widenmaier, SB; Ao, ZL; Kim, SJ; Warnock, G; McIntosh, CHS,期刊:Journal of Biological Chemistry, 页码:30372-30382 , 文章类型: Article,,卷期:2009年284-44]
- Glucose-dependent insulinotropic polypeptide (GIP) potentiates glucose-stimulated insulin secretion, insulin biosynthesis, and beta-cell proliferation and survival. In previous studies GIP was shown to promote beta-cell ...
- Response of Gastric Epithelial Progenitors to Helicobacter pylori Isolates Obtained from Swedish Patients with Chronic Atrophic Gastritis
[作者:Giannakis, M; Backhed, HK; Chen, SL; Faith, JJ; Wu, M; Guruge, JL; Engstrand, L; Gordon, JI,期刊:Journal of Biological Chemistry, 页码:30383-30394 , 文章类型: Article,,卷期:2009年284-44]
- Helicobacter pylori infection is associated with gastric adenocarcinoma in some humans, especially those that develop an antecedent condition, chronic atrophic gastritis (ChAG). Gastric epithelial progenitors (GEPs) in t...
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