- Therapeutic potential of an anti-CD79b antibody-drug conjugate, anti-CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma
[作者：Dornan, D; Bennett, F; Chen, Y; Dennis, M; Eaton, D; Elkins, K; French, D; Go, MAT; Jack, A; Junutula, JR; Koeppen, H; Lau, J; McBride, J; Rawstron, A; Shi, XY; Yu, N; Yu, SF; Yue, P; Zheng, B; Ebens, A; Polson, AG,期刊：Blood, 页码：2721-2729 , 文章类型： Article，,卷期：2009年114-13]
- Here we describe the generation of an antibody-drug conjugate (ADC) consisting of a humanized anti-CD79b antibody that is conjugated to monomethylauristatin E (MMAE) through engineered cysteines (THIOMABs) by a protease ...
- A prospective study of serum soluble CD30 concentration and risk of non-Hodgkin lymphoma
[作者：Purdue, MP; Lan, Q; Martinez-Maza, O; Oken, MM; Hocking, W; Huang, WY; Baris, D; Conde, B; Rothman, N,期刊：Blood, 页码：2730-2732 , 文章类型： Article，,卷期：2009年114-13]
- Prediagnostic serum concentration of soluble CD30 (sCD30), a marker for chronic B-cell stimulation, has been associated with increased risk of developing AIDS-related non-Hodgkin lymphoma (NHL) in a recent study of HIV+ ...
- Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells
[作者：Fiskus, W; Wang, YC; Sreekumar, A; Buckley, KM; Shi, HD; Jillella, A; Ustun, C; Rao, R; Fernandez, P; Chen, JG; Balusu, R; Koul, S; Atadja, P; Marquez, VE; Bhalla, KN,期刊：Blood, 页码：2733-2743 , 文章类型： Article，,卷期：2009年114-13]
- The polycomb repressive complex (PRC) 2 contains 3 core proteins, EZH2, SUZ12, and EED, in which the SET (suppressor of variegation-enhancer of zeste-trithorax) domain of EZH2 mediates the histone methyltransferase activ...
- RUNX1 regulates phosphoinositide 3-kinase/AKT pathway: role in chemotherapy sensitivity in acute megakaryocytic leukemia
[作者：Edwards, H; Xie, CZ; LaFiura, KM; Dombkowski, AA; Buck, SA; Boerner, JL; Taub, JW; Matherly, LH; Ge, YB,期刊：Blood, 页码：2744-2752 , 文章类型： Article，,卷期：2009年114-13]
- RUNX1 (AML1) encodes the core binding factor alpha subunit of a heterodimeric transcription factor complex which plays critical roles in normal hematopoiesis. Translocations or down-regulation of RUNX1 have been linked t...
- Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome
[作者：Cabelof, DC; Patel, HV; Chen, Q; van Remmen, H; Matherly, LH; Ge, YB; Taub, JW,期刊：Blood, 页码：2753-2763 , 文章类型： Article，,卷期：2009年114-13]
- Down syndrome (DS) children have a unique genetic susceptibility to develop leukemia, in particular, acute megakaryocytic leukemia (AMkL) associated with somatic GATA1 mutations. The study of this genetic susceptibility ...
- Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies
[作者：Fandy, TE; Herman, JG; Kerns, P; Jiemjit, A; Sugar, EA; Choi, SH; Yang, AS; Aucott, T; Dauses, T; Odchimar-Reissig, R; Licht, J; McConnell, MJ; Nasrallah, C; Kim, MKH; Zhang, WJ; Sun, YZ; Murgo, A; Espinoza-Delgado, I; Oteiza, K; Owoeye, I; Silverman, LR; Gore, SD; Carraway, HE,期刊：Blood, 页码：2764-2773 , 文章类型： Article，,卷期：2009年114-13]
- Sequential administration of DNA methyltransferase (DNMT) inhibitors and histone deacetylase (HDAC) inhibitors has demonstrated clinical efficacy in patients with hematologic malignancies. However, the mechanism behind t...
- Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner
[作者：Kottyan, LC; Collier, AR; Cao, KH; Niese, KA; Hedgebeth, M; Radu, CG; Witte, ON; Hershey, GKK; Rothenberg, ME; Zimmermann, N,期刊：Blood, 页码：2774-2782 , 文章类型： Article，,卷期：2009年114-13]
- The microenvironment of the lung in asthma is acidic, yet the effect of acidity on inflammatory cells has not been well established. We now demonstrate that acidity inhibits eosinophil apoptosis and increases cellular vi...
- The Duffy-null state is associated with a survival advantage in leukopenic HIV-infected persons of African ancestry
[作者：Kulkarni, H; Marconi, VC; He, WJ; Landrum, ML; Okulicz, JF; Delmar, J; Kazandjian, D; Castiblanco, J; Ahuja, SS; Wright, EJ; Weiss, RA; Clark, RA; Dolan, MJ; Ahuja, SK,期刊：Blood, 页码：2783-2792 , 文章类型： Article，,卷期：2009年114-13]
- Persons of African ancestry, on average, have lower white blood cell (WBC) counts than those of European descent (ethnic leukopenia), but whether this impacts negatively on HIV-1 disease course remains unknown. Here, in ...
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