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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共75条记录   Hirtellanines A and B, a pair of isomeric isoflavonoid derivatives from Campylotropis hirtella and their immunosuppressive activities [作者：Shou, QY; Tan, Q; Shen, ZW,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3389-3391 , 文章类型： Article，,卷期：2009年19-13] A pair of isomeric isoflavonoid derivatives, Hirtellanines A (1) and B (2), has been isolated from the roots of Campylotropis hirtella (Franch.) Schindl. and their structures were elucidated on the basis of spectroscopic... Synthesis of 4-substituted pyrido[2,3-d]pyrimidin-4(1H)-one as analgesic and anti-inflammatory agents [作者：El-Gazzar, ARBA; Hafez, HN,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3392-3397 , 文章类型： Article，,卷期：2009年19-13] 4-Substituted-pyrido[2,3-d]pyrimidin-4(1H)-ones 4a-c were synthesized by oxidation of 4-substituted-dihydropyrido[2,3-d]pyrimidin-4(1H)-ones 3a-c which were in turn prepared from arylidenemalononitriles 1a-c and 6-aminot... Discovery of spirocyclic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors [作者：Shen, HC; Ding, FX; Wang, SY; Xu, SY; Chen, HS; Tong, X; Tong, V; Mitra, K; Kumar, S; Zhang, XP; Chen, YL; Zhou, GC; Pai, LY; Alonso-Galicia, M; Chen, XL; Zhang, B; Tata, JR; Berger, JP; Colletti, SL,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3398-3404 , 文章类型： Article，,卷期：2009年19-13] Spirocyclic secondary amine-derived trisubstituted ureas were identified as highly potent, bioavailable and selective soluble epoxide hydrolase (sEH) inhibitors. Despite good oral exposure and excellent ex vivo target en... Substituted benzimidazoles: A novel chemotype for small molecule hKSP inhibitors [作者：Lahue, BR; Ma, Y; Shipps, GW; Seghezzi, W; Herbst, R,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3405-3409 , 文章类型： Article，,卷期：2009年19-13] Substituted benzimidazoles were pro. led as inhibitors of kinesin spindle protein (KSP), an increasingly important target for the development of anticancer drugs. This series demonstrated the monoastral phenotypic respon... Carrier PNA for shRNA delivery into cells [作者：Kitamatsu, M; Kubo, T; Matsuzaki, R; Endoh, T; Ohtsuki, T; Sisido, M,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3410-3413 , 文章类型： Article，,卷期：2009年19-13] A peptide nucleic acid (PNA)-cell-penetrating peptide (CPP) conjugate (carrier PNA) was used as 'bridgebuilder' to connect a CPP with an shRNA. The carrier PNA successfully formed a hybrid with an shRNA bearing complemen... Synthesis and evaluation of 9-O-substituted berberine derivatives containing aza-aromatic terminal group as highly selective telomeric G-quadruplex stabilizing ligands [作者：Ma, Y; Ou, TM; Tan, JH; Hou, JQ; Huang, SL; Gu, LQ; Huang, ZS,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3414-3417 , 文章类型： Article，,卷期：2009年19-13] A series of new 9-O-substituted berberine derivatives (4a-j) as telomeric quadruplex ligands was synthesized and evaluated. The results from biophysical and biochemical assay indicated that introducing of positive charge... Novel sulfone-containing di- and trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists [作者：Cherney, RJ; Mo, RW; Meyer, DT; Voss, ME; Lo, YC; Yang, GJ; Miller, PB; Scherle, PA; Tebben, AJ; Carter, PH; Decicco, CP,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3418-3422 , 文章类型： Article，,卷期：2009年19-13] Potent sulfone-containing di- and trisubstituted cyclohexanes were synthesized and evaluated as CC chemokine receptor 2 (CCR2) antagonists. This led to the trisubstituted derivative 54, which exhibited excellent binding ... Synthesis and biological evaluation of platinum-acridine hybrid agents modified with bipyridine non-leaving groups [作者：Kheradi, AR; Saluta, G; Kucera, GL; Day, CS; Bierbach, U,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3423-3425 , 文章类型： Article，,卷期：2009年19-13] The use of 2,2'-bipyridines (4,4'-R-2-2,2'-bpy; R = H, Me, OMe, CF3) as non-leaving groups (L-L) in platinum-acridinylthiourea conjugates, [PtCl(L-L)(ACRAMTU)](NO3)(2), has been investigated. All bpy-substituted complexe... Discovery of novel motilin antagonists: Conversion of tetrapeptide leads to orally available peptidomimetics [作者：Taka, N; Matsuoka, H; Sato, T; Yoshino, H; Imaoka, I; Sato, H; Kotake, K; Kumagai, Y; Kamei, K; Ozaki, KI; Higashida, A; Kuroki, T,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3426-3429 , 文章类型： Article，,卷期：2009年19-13] We successfully discovered peptidomimetic motilin antagonists (17c and 17d) through the improvement of physicochemical properties of a tetrapeptide antagonist (2). Furthermore, with oral administration and based on motil... Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines [作者：Innocenti, A; Hilvo, M; Parkkila, S; Scozzafava, A; Supuran, CT,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3430-3433 , 文章类型： Article，,卷期：2009年19-13] An activation study of the membrane-associated carbonic anhydrase (CA, EC 4.2.1.1) isoform XV with a series of natural and non-natural amino acids and aromatic/heterocyclic amines is reported. Murine CA XV was strongly a... 2,6-Diphenylthiazolo[3,2-b][1,2,4]triazoles as telomeric G-quadruplex stabilizers [作者：El Bakali, J; Klupsch, F; Guedin, A; Brassart, B; Fontaine, G; Farce, A; Roussel, P; Houssin, R; Bernier, JL; Chavatte, P; Mergny, JL; Riou, JF; Henichart, JP,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3434-3438 , 文章类型： Article，,卷期：2009年19-13] design and synthesis of 2,6-diphenylthiazolo[3,2-b][1,2,4] triazoles characterized by a large aromatic building block bearing cationic side chains are reported. These molecules are evaluated as telomeric G-quadruplex sta... Synthesis of C-11-labeled 2-aminoethanol via a nitroaldol reaction using nitro[C-11]methane [作者：Kato, K; Zhang, MR; Minegishi, K; Suzuki, K,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3439-3441 , 文章类型： Article，,卷期：2009年19-13] The nitroaldol reaction of nitro[C-11] methane and formaldehyde using EtOH and EtONa efficiently provided 2-nitro[C-11] ethanol in 3 min. The nitro group reduction in the presence of NiCl2 and NaBH4 in MeOH followed by p... Fast and easy access to efficient bifunctional chelators for MRI applications [作者：Gugliotta, G; Botta, M; Giovenzana, GB; Tei, L,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3442-3444 , 文章类型： Article，,卷期：2009年19-13] Novel bifunctional agents based on the AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid) structure with hydroxyl, carboxyl and chloro functional groups were prepared. The Gd-III complexes show optimal magnet... Synthesis and activity of quinolinylmethyl P1 ' alpha-sulfone piperidine hydroxamate inhibitors of TACE [作者：Zhang, CC; Lovering, F; Behnke, M; Zask, A; Sandanayaka, V; Sun, LH; Zhu, Y; Xu, WX; Zhang, YH; Levin, JI,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3445-3448 , 文章类型： Article，,卷期：2009年19-13] A series of alpha-sulfone piperidine hydroxamate TACE inhibitors 11a-n bearing a quinolinyl methyl P1' group was prepared, and their activity was compared to analogous alpha- and beta-sulfone piperidine hydroxamates with... Bis-neonicotinoid insecticides: Observed and predicted binding interactions with the nicotinic receptor [作者：Ohno, I; Tomizawaa, M; Durkin, KA; Casida, JE; Kagabu, S,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3449-3452 , 文章类型： Article，,卷期：2009年19-13] The bis-pharmacophore approach applied to neonicotinoid insecticides reveals high binding affinity for heptamethylene bis-N-3,N-3'-imidacloprid fitting a nicotinic acetylcholine receptor model wherein the chloropyridine ... Discovery of novel phosphonate derivatives as hepatitis C virus NS3 protease inhibitors [作者：Sheng, XC; Pyun, HJ; Chaudhary, K; Wang, JY; Doerffler, E; Fleury, M; McMurtrie, D; Chen, XW; Delaney, WE; Kim, CU,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3453-3457 , 文章类型： Article，,卷期：2009年19-13] A novel class of phosphonate derivatives was designed to mimic the interaction of product-like carboxylate based inhibitors of HCV NS3 protease. A phosphonic acid (compound 2) was demonstrated to be a potent HCV NS3 prot...