- Synthesis and in vitro cytotoxicity of 9-anilinoacridines bearing N-mustard residue on both anilino and acridine rings
[作者:Chen, CH; Lin, YW; Zhang, XG; Chou, TC; Tsai, TJ; Kapuriya, N; Kakadiya, R; Su, TL,期刊:European Journal of Medicinal Chemistry, 页码:3056-3059 , 文章类型: Article,,卷期:2009年44-7]
- A series of 9-anilinoacridines having an alkylating N-mustard pharmacophore on both anilino (C-3' or C-4') and acridine (C-4) rings with O-ethyl (O-C-2) or O-butyl (O-C-4) spacer were synthesized to evaluate their cytoto...
- Design, synthesis, and antifungal activity of triazole and benzotriazole derivatives
[作者:Rezaei, Z; Khabnadideh, S; Pakshir, K; Hossaini, Z; Amiri, F; Assadpour, E,期刊:European Journal of Medicinal Chemistry, 页码:3064-3067 , 文章类型: Article,,卷期:2009年44-7]
- This study describes the design, synthesis and evaluation of a novel series of 1,2,4-triazole and benzotriazole derivatives as inhibitors of cytochrome P450 14 alpha-demethylase (14DM). The chemical structures of the new...
- Synthesis and investigation of anti-inflammatory activity and gastric ulcerogenicity of novel nitric oxide-donating pyrazoline derivatives
[作者:Shoman, ME; Abdel-Aziz, M; Aly, OM; Farag, HH; Morsy, MA,期刊:European Journal of Medicinal Chemistry, 页码:3068-3076 , 文章类型: Article,,卷期:2009年44-7]
- A group of 3,5-diaryl-2-pyrazoline derivatives were prepared via the reaction of various chalcones with hydrazine hydrate in ethanol. A group of NO-donating-2-pyrazoline derivatives were synthesized by carrying a nitrate...
- Synthesis, characterization and antibacterial activity of some triazole Mannich bases carrying diphenylsulfone moieties
[作者:Almajan, GL; Barbuceanu, SF; Almajan, ER; Draghici, C; Saramet, G,期刊:European Journal of Medicinal Chemistry, 页码:3083-3089 , 文章类型: Article,,卷期:2009年44-7]
- A series of Mannich bases of 4-substituted 5-[4-(4-X-phenyisulfonyl)phenyl]-2,4-dihydro-3H-1,2,4-triazole-3-thiones, X = H, Cl, Br, 3 and 5 were synthesized and characterized on the basis of IR, NMR and elemental analyse...
- Novel CYP17 inhibitors: Synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls
[作者:Hille, UE; Hu, QZ; Vock, C; Negri, M; Bartels, M; Muller-Vieira, U; Lauterbach, T; Hartmann, RW,期刊:European Journal of Medicinal Chemistry, 页码:2765-2775 , 文章类型: Article,,卷期:2009年44-7]
- Recently, the steroidal CYP17 inhibitor Abiraterone entered phase 11 clinical trial for the treatment of androgen-dependent prostate cancer. As 17 alpha-hydroxylase-17,20-lyase (CYP17) catalyzes the last step in androgen...
- Synthesis of some new 1,3,4-thiadiazol-2-ylmethyl-1,2,4-triazole derivatives and investigation of their antimicrobial activities
[作者:Demirbas, A; Sahin, D; Demirbas, N; Karaoglu, SA,期刊:European Journal of Medicinal Chemistry, 页码:2896-2903 , 文章类型: Article,,卷期:2009年44-7]
4-Amino-2-[(5-arylamino-4,5-dihydro-1,3,4-thiadiazol-2-yl)methyl]-5-(4-methylphenyl)-2,4-dihydro-3H-1,2,4-triazol-3-ones(3a-c) were obtained in acidic media via the formation of 2-[(4-amino-3-aryl-5-oxo-4,5-dihydro-1H...
- Comparative chemometric modeling of cytochrome 3A4 inhibitory activity of structurally diverse compounds using stepwise MLR, FA-MLR, PLS, GFA, G/PLS and ANN techniques
[作者:Roy, K; Roy, PP,期刊:European Journal of Medicinal Chemistry, 页码:2913-2922 , 文章类型: Article,,卷期:2009年44-7]
- Twenty-eight structurally diverse cytochrome 3A4 (CYP3A4) inhibitors have been subjected to quantitative structure-activity relationship (QSAR) studies. The analyses were performed with electronic, spatial, topological, ...
|