- Synthesis and antiviral activity of new pyrazole and thiazole derivatives
[作者：El-Sabbagh, OI; Baraka, MM; Ibrahim, SM; Pannecouque, C; Andrei, G; Snoeck, R; Balzarini, J; Rashad, AA,期刊：European Journal of Medicinal Chemistry, 页码：3746-3753 , 文章类型： Article，,卷期：2009年44-9]
- New N-acetyl (5-8) and N-thiocarbamoyl (9-12) derivatives of 4,5-dihydropyrazole were synthesized starting from alpha,beta-unsaturated ketones under the effect of hydrazine hydrate and thiosemicarbazide, respectively. N-...
- New potential AChE inhibitor candidates
[作者：de Paula, AAN; Martins, JBL; dos Santos, ML; Nascente, LD; Romeiro, LAS; Areas, TFMA; Vieira, KST; Gamboa, NF; Castro, NG; Gargano, R,期刊：European Journal of Medicinal Chemistry, 页码：3754-3759 , 文章类型： Article，,卷期：2009年44-9]
- We have theoretically studied new potential candidates of acetylcholinesterase (AChE) inhibitors designed from cardanol, a non-isoprenoid phenolic lipid of cashew Anacardium occidentale nut-shell liquid. The electronic s...
- Cyclic phosphoramidates as prodrugs of 2 '-C-methylcytidine
[作者：Meppen, M; Pacini, B; Bazzo, R; Koch, U; Leone, JF; Koeplinger, KA; Rowley, M; Altamura, S; Di Marco, A; Fiore, F; Giuliano, C; Gonzalez-Paz, O; Laufer, R; Pucci, V; Narjes, F; Gardelli, C,期刊：European Journal of Medicinal Chemistry, 页码：3765-3770 , 文章类型： Article，,卷期：2009年44-9]
- The currently approved treatment for hepatitis C virus infections is a combination of Ribavirin and pegylated Interferon. It leads to a sustained virologic response in approximately only half of the patients treated. For...
- Synthesis and bioactivity of substituted indan-1-ylidene aminoguanidine derivatives
[作者：Zhang, R; Dong, J; Xu, YG; Hua, WY; Wen, N; You, QD,期刊：European Journal of Medicinal Chemistry, 页码：3771-3776 , 文章类型： Article，,卷期：2009年44-9]
- In our efforts to discover more potent and lasting NHE1 inhibitors, we designed and synthesized a series of substituted indan-1-ylidene aminoguanidine derivatives (5). NHE1 inhibitory activity of twenty-one compounds 5 w...
- Antiviral evaluation of N-amino-1,2,3-triazoles against Cantagalo virus replication in cell culture
[作者：Jordao, AK; Afonso, PP; Ferreira, VF; de Souza, MCBV; Almeida, MCB; Beltrame, CO; Paiva, DP; Wardell, SMSV; Wardell, JL; Tiekink, ERT; Damaso, CR; Cunha, AC,期刊：European Journal of Medicinal Chemistry, 页码：3777-3783 , 文章类型： Article，,卷期：2009年44-9]
- This paper describes the antiviral evaluation of new N-amino-1,2,3-triazole derivatives, 1-(substituted-phenylamino)-5-methyl-1H-[1,2,3]-triazole-4-carboxylic acid ethyl esters, 3 and 1-(4-substituted-phenylamino)-5-meth...
- Regioselective reaction: Synthesis, characterization and pharmacological studies of some new Mannich bases derived from 1,2,4-triazoles
[作者：Isloor, AM; Kalluraya, B; Shetty, P,期刊：European Journal of Medicinal Chemistry, 页码：3784-3787 , 文章类型： Article，,卷期：2009年44-9]
- In the present investigation, a series of new 4[(3-substituted-1H-pyrazol-4-yl)methyleneamino]-5-substituted-2-[(4-methylpiperzine-1-yl)methyl]-2H-1,2,4-triazole-3(4H)-thiones (4) were synthesized by the aminomethylation...
- Synthesis, structure elucidation and antitumour activity of N-substituted amides of 3-(3-ethylthio-1,2,4-triazol-5-yl)propenoic acid
[作者：Pachuta-Stec, A; Rzymowska, J; Mazur, L; Mendyk, E; Pitucha, M; Rzaczynska, Z,期刊：European Journal of Medicinal Chemistry, 页码：3788-3793 , 文章类型： Article，,卷期：2009年44-9]
New N-substituted amides of 3-(3-ethylthio-1,2,4-triazol-5-yl)propenoic acid (2-12) were designed and prepared by the condensation reaction of exo-S-ethyl-7-oxabicyclo-[2.2.1]-hept-5-ene-2,3-dicarbonyl isothiosemicarb...
- Structure-activity relationship of seco-tanapartholides isolated from Achillea falcata for inhibition of HaCaT cell growth
[作者：Ghantous, A; Nasser, N; Saab, I; Darwiche, N; Saliba, NA,期刊：European Journal of Medicinal Chemistry, 页码：3794-3797 , 文章类型： Article，,卷期：2009年44-9]
- Four sesquiterpene lactones were isolated from Achillea falcata, through bioassay-guided fractionation, based on their differential ability to affect HaCaT cell growth. Identified seco-tanapartholides: 3-beta-methoxy-iso...
- Fenbufen based 3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]-1-(biphenyl-4-yl)propan-1-ones as safer antiinflammatory and analgesic agents
[作者：Husain, A; Ahmad, A; Alam, MM; Ajmal, M; Ahuja, P,期刊：European Journal of Medicinal Chemistry, 页码：3798-3804 , 文章类型： Article，,卷期：2009年44-9]
- The synthesis of a series of 3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]-1-(biphenyl-4-yl)propan-1-ones derived from 4-oxo-4-(biphenyl-4-yl)butanoic acid (fenbufen) is described. The structures of these compounds were ...
- A facile one-pot green synthesis and antibacterial activity of 2-amino-4H-pyrans and 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromenes
[作者：Kumar, D; Reddy, VB; Sharad, S; Dube, U; Kapur, S,期刊：European Journal of Medicinal Chemistry, 页码：3805-3809 , 文章类型： Article，,卷期：2009年44-9]
A facile one-pot expeditious synthesis of 2-amino-4H-pyrans and 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromenes has been described under solvent-free conditions using magnesium oxide as a catalyst in very good yields. T...
- Antimalarial pharmacodynamics of chalcone derivatives in combination with artemisinin against Plasmodium falciparum in vitro
[作者：Bhattacharya, A; Mishra, LC; Sharma, M; Awasthi, SK; Bhasin, VK,期刊：European Journal of Medicinal Chemistry, 页码：3388-3393 , 文章类型： Article，,卷期：2009年44-9]
- Use of artemisinin based combination therapies (ACTs) is increasing in treatment of malaria. Their extensive and indiscriminate deployment will ultimately lead to selection of resistance. Thus, alternate ACTs are needed....
- Synthesis and biochemical evaluation of a cyclic RGD oxorhenium complex as new ligand of alpha(V)beta(3) integrin
[作者：Aufort, M; Gonera, M; Chaignon, N; Le Clainche, L; Dugave, C,期刊：European Journal of Medicinal Chemistry, 页码：3394-3401 , 文章类型： Article，,卷期：2009年44-9]
- We report the design of a new ligand of integrins that might be used for the molecular imaging of tumor neoangiogenesis. For this purpose, we designed a modified RGD tripeptide bearing a N-terminal N-bis(thioethyl)glycin...
- Synthesis, antimalarial evaluation and molecular modeling studies of hydroxyethylpiperazines, potential aspartyl protease inhibitors, Part 2
[作者：Cunico, W; Gomes, CRB; Facchinetti, V; Moreth, M; Penido, C; Henriques, MGMO; Varotti, FP; Krettli, LG; Krettli, AU; da Silva, FS; Caffarena, ER; de Magalhaes, CS,期刊：European Journal of Medicinal Chemistry, 页码：3816-3820 , 文章类型： Article，,卷期：2009年44-9]
- The antimalarial acitivity of hydroxyethylamines, synthesized from the reaction of intermediated hydroxyethypiperazines with benzenesulfonyl chlorides or benzoyl chlorides, has been evaluated in vitro against a W2 Plasmo...
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