- Preparation and antitubercular activities in vitro and in vivo of novel Schiff bases of isoniazid
[作者:Hearn, MJ; Cynamon, MH; Chen, MF; Coppins, R; Davis, J; Kang, HJO; Noble, A; Tu-Sekine, B; Terrot, MS; Trombino, D; Thai, M; Webster, ER; Wilson, R,期刊:European Journal of Medicinal Chemistry, 页码:4169-4178 , 文章类型: Article,,卷期:2009年44-10]
- Structural modification of the frontline antitubercular isonicotinic acid hydrazide (INH) provides lipophilic adaptations (3-46) of the drug in which the hydrazine moiety of the parent compound has been chemically blocke...
- Chiral 3-(4,5-dihydrooxazol-2-yl)phenyl alkylcarbamates as novel FAAH inhibitors: Insight into FAAH enantioselectivity by molecular docking and interaction fields
[作者:Myllymaki, MJ; Kasnanen, H; Kataja, AO; Lahtela-Kakkonen, M; Saario, SM; Poso, A; Koskinen, AMP,期刊:European Journal of Medicinal Chemistry, 页码:4179-4191 , 文章类型: Article,,卷期:2009年44-10]
- Fatty acid amide hydrolase (FAAH) and monoglyceride lipase (MGL) are the main enzymes responsible for the hydrolysis of endogenous cannabinoids N-arachidonoylethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), respecti...
- Synthesis, spectral and biological evaluation of some new thiazolidinones and thiazoles based on t-3-alkyl-r-2,c-6-diarylpiperidin-4-ones
[作者:Aridoss, G; Amirthaganesan, S; Kim, MS; Kim, JT; Jeong, YT,期刊:European Journal of Medicinal Chemistry, 页码:4199-4210 , 文章类型: Article,,卷期:2009年44-10]
- A stereospecific synthesis of some thiazolidinones and thiazoles was achieved conveniently through certain alpha-halo keto agents and reactivity of chloroacetyl chloride was successfully enhanced by CsF-Celite + CH3COONa...
- New azoles with potent antifungal activity: Design, synthesis and molecular docking
[作者:Che, XY; Sheng, CQ; Wang, WY; Cao, YB; Xu, YL; Ji, HT; Dong, GQ; Miao, ZY; Yao, JZ; Zhang, WN,期刊:European Journal of Medicinal Chemistry, 页码:4218-4226 , 文章类型: Article,,卷期:2009年44-10]
- In response to the urgent need for novel antifungal agents with improved activity and broader spectrum, computer modeling was used to rational design novel antifungal azoles. On the basis of the active site of lanosterol...
- Contact-active microbicidal gold surfaces using immobilization of quaternary ammonium thiol derivatives
[作者:Thebault, P; de Givenchy, ET; Levy, R; Vandenberghe, Y; Guittard, F; Geribaldi, S,期刊:European Journal of Medicinal Chemistry, 页码:4227-4234 , 文章类型: Article,,卷期:2009年44-10]
- Contact-active auto-bactericidal surfaces were obtained by grafting of specially designed thiol derivatives containing antimicrobial quaternary ammonium moieties on gold substrates. The formation and quality of the self-...
- Inhibitory effects of 5-benzylidene barbiturate derivatives on mushroom tyrosinase and their antibacterial activities
[作者:Yan, Q; Cao, RH; Yi, W; Chen, ZY; Wen, H; Ma, L; Song, HC,期刊:European Journal of Medicinal Chemistry, 页码:4235-4243 , 文章类型: Article,,卷期:2009年44-10]
- A series of novel 5-benzylidene barbiturate and thiobarbiturate derivatives were synthesized and evaluated as tyrosinase inhibitors and antibacterial agents. The results demonstrated that some compounds had more potent i...
- Design, synthesis and antimycobacterial activity of some novel imidazo[1,2-c]pyrimidines
[作者:Chhabria, MT; Jani, MH,期刊:European Journal of Medicinal Chemistry, 页码:3837-3844 , 文章类型: Article,,卷期:2009年44-10]
Tuberculosis, due to its relentless nature, is now a major public health threat. The concomitant resurgence of TB with the MDR- or XDR-TB and HIV/AIDS pandemic has exposed the frailties of the current drug armatorium....
- Synthesis, antiviral activity, and stability of nucleoside analogs containing tricyclic bases
[作者:Amblard, F; Fromentin, E; Detorio, M; Obikhod, A; Rapp, KL; McBrayer, TR; Whitaker, T; Coats, SJ; Schinazi, RF,期刊:European Journal of Medicinal Chemistry, 页码:3845-3851 , 文章类型: Article,,卷期:2009年44-10]
- A series of 3,9-dihydro-9-oxo-5H-imidazo[1,2-A]purine nucleosides (tricylic nucleosides) were synthesized from 9-[4-alpha(hydroxymethyl)cyclopent-2-ene-l-alpha-yl]guanine (CBV) 5, (-)-beta-D-(2R,4R)-1,3-dioxo-lane-guanos...
- Synthesis and antitumoral activity of novel thiazolobenzotriazole, thiazoloindolo[3,2-c]quinoline and quinolinoquinoline derivatives
[作者:Beauchard, A; Jaunet, A; Murillo, L; Baldeyrou, B; Lansiaux, A; Cherouvrier, JR; Domon, L; Picot, L; Bailly, C; Besson, T; Thiery, V,期刊:European Journal of Medicinal Chemistry, 页码:3858-3865 , 文章类型: Article,,卷期:2009年44-10]
- The biological evaluation of some novel thiazoloindolo[3,2-c]quinoline, 8-substituted-11H-indolo[3,2-c]quinolines is described. These compounds were obtained via Graebe-Ullmann thermal cyclization from appropriated N-ary...
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