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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共41条记录   Intermediate filaments: primary determinants of cell architecture and plasticity [作者：Herrmann, H; Strelkov, SV; Burkhard, P; Aebi, U,期刊：Journal of clinical investigation, 页码：1772-1783 , 文章类型： Review，,卷期：2009年119-7] Intermediate filaments (IFs) are major constituents of the cytoskeleton and nuclear boundary in animal cells. They are of prime importance for the functional organization of structural elements. Depending on the cell typ... Epidermolysis bullosa simplex: a paradigm for disorders of tissue fragility [作者：Coulombe, PA; Kerns, ML; Fuchs, E,期刊：Journal of clinical investigation, 页码：1784-1793 , 文章类型： Review，,卷期：2009年119-7] Epidermolysis bullosa (EB) simplex is a rare genetic condition typified by superficial bullous lesions that result from frictional trauma to the skin. Most cases are due to dominantly acting mutations in either keratin 1... Toward unraveling the complexity of simple epithelial keratins in human disease [作者：Omary, MB; Ku, NO; Strnad, P; Hanada, S,期刊：Journal of clinical investigation, 页码：1794-1805 , 文章类型： Review，,卷期：2009年119-7] Simple epithelial. keratins (SEKs) are found primarily in single-layered simple epithelia and include keratin 7 (K7), K8, K18-K20, and K23. Genetically engineered mice that lack SEKs or overexpress mutant SEKs have helpe... Tragedy in a heartbeat: malfunctioning desmin causes skeletal and cardiac muscle disease [作者：Goldfarb, LG; Dalakas, MC,期刊：Journal of clinical investigation, 页码：1806-1813 , 文章类型： Review，,卷期：2009年119-7] Muscle fiber deterioration resulting in progressive skeletal muscle weakness, heart failure, and respiratory distress occurs in more than 20 inherited myopathies. As discussed in this Review, one of the newly identified ... Dysfunctions of neuronal and glial intermediate filaments in disease [作者：Liem, RKH; Messing, A,期刊：Journal of clinical investigation, 页码：1814-1824 , 文章类型： Review，,卷期：2009年119-7] Intermediate Filaments (IFs) are abundant structures found in most eukaryotic cells, including those in the nervous system. In the CNS, the primary components of neuronal IFs are a-internexin and the neurofilament triple... CCR1 and CCR5 promote hepatic fibrosis in mice [作者：Seki, E; De Minicis, S; Gwak, GY; Kluwe, J; Inokuchi, S; Bursill, CA; Llovet, JM; Brenner, DA; Schwabe, RF,期刊：Journal of clinical investigation, 页码：1858-1870 , 文章类型： Article，,卷期：2009年119-7] Hepatic fibrosis develops as a response to chronic liver injury and almost exclusively occurs in a proinflammatory environment. However, the role of inflammatory mediators in fibrogenic responses of the liver is only poo... Laminopathies and the long strange trip from basic cell biology to therapy [作者：Worman, HJ; Fong, LG; Muchir, A; Young, SG,期刊：Journal of clinical investigation, 页码：1825-1836 , 文章类型： Review，,卷期：2009年119-7] The main function of the nuclear lamina, an intermediate filament meshwork lying primarily beneath the inner nuclear membrane, is to provide structural scaffolding for the cell nucleus. However, the lamina also serves ot... Functions of the intermediate filament cytoskeleton in the eye lens [作者：Song, SH; Landsbury, A; Dahm, R; Liu, YZ; Zhang, QJ; Quinlan, RA,期刊：Journal of clinical investigation, 页码：1837-1848 , 文章类型： Review，,卷期：2009年119-7] Intermediate filaments (IFs) are a key component of the cytoskeleton in virtually all vertebrate cells, including those of the lens of the eye. IFs help integrate individual cells into their respective tissues. This Revi... Stephen Emerson goes back to his roots [作者：Honey, K,期刊：Journal of clinical investigation, 页码：1742-1742 , 文章类型： News Item，,卷期：2009年119-7]