- Osteoprotegerin Abrogated Cortical Porosity and Bone Marrow Fibrosis in a Mouse Model of Constitutive Activation of the PTH/PTHrP Receptor
[作者:Ohishi, M; Chiusaroli, R; Ominsky, M; Asuncion, F; Thomas, C; Khatri, R; Kostenuik, P; Schipani, E,期刊:American Journal of Pathology, 页码:2160-2171 , 文章类型: Article,,卷期:2009年174-6]
- Intracortical porosities and marrow fibrosis are hallmarks of hyperparathyroidism and are present in bones of transgenic mice expressing constitutively active parathyroid hormone/parathyroid hormone-related protein recep...
- Monokine Induced by Interferon-gamma (MIG/CXCL9) Is Derived from Both Donor and Recipient Sources during Rejection of Class II Major Histocompatibility Complex Disparate Skin Allografts
[作者:Auerbach, MB; Shimoda, N; Amano, H; Rosenblum, JM; Kish, DD; Farber, JM; Fairchild, RL,期刊:American Journal of Pathology, 页码:2172-2181 , 文章类型: Article,,卷期:2009年174-6]
- Chemokines, including monokine induced by interferon-gamma (Mig/CXCL9), are produced both in allografts and during the direct T-cell infiltration that mediates graft rejection. Neither the specific production nor contrib...
- Urokinase Plasminogen Activator Receptor-Deficient Mice Demonstrate Reduced Hyperoxia-Induced Lung Injury
[作者:van Zoelen, MAD; Florquin, S; de Beer, R; Pater, JM; Verstege, MI; Meijers, JCM; van der Poll, T,期刊:American Journal of Pathology, 页码:2182-2189 , 文章类型: Article,,卷期:2009年174-6]
- Patients with respiratory failure often require supplemental oxygen therapy and mechanical ventilation. Although both supportive measures are necessary to guarantee adequate oxygen uptake, they can also cause or worsen l...
- Dominant Role of the sst1 Locus in Pathogenesis of Necrotizing Lung Granulomas during Chronic Tuberculosis Infection and Reactivation in Genetically Resistant Hosts
[作者:Pichugin, AV; Yan, BS; Sloutsky, A; Kobzik, L; Kramnik, I,期刊:American Journal of Pathology, 页码:2190-2201 , 文章类型: Article,,卷期:2009年174-6]
- Significant host heterogeneity in susceptibility to tuberculosis exists both between and within mammalian species. Using a mouse model of infection with virulent Mycobacterium tuberculosis (Mtb), we identified the geneti...
- Mucosal Tolerance Induced by an Immunodominant Peptide from Rat alpha 3(IV)NC1 in Established Experimental Autoimmune Glomerulonephritis
[作者:Reynolds, J; Abbott, DS; Karegli, J; Evans, DJ; Pusey, CD,期刊:American Journal of Pathology, 页码:2202-2210 , 文章类型: Article,,卷期:2009年174-6]
- Experimental autoimmune glomerulonephritis (EAG), an animal model of Goodpasture's disease, can be induced in Wistar Kyoto (WKY) rats by immunization with the noncollagenous domain of the a 3 chain of type IV collagen, a...
- Compartmentalization of Immune Responses in Human Tuberculosis Few CD8 + Effector T Cells but Elevated Levels of FbxP3 + Regulatory T Cells in the Granulomatous Lesions
[作者:Rahman, S; Gudetta, B; Fink, J; Granath, A; Ashenafi, S; Aseffa, A; Derbew, M; Svensson, M; Andersson, J; Brighenti, SG,期刊:American Journal of Pathology, 页码:2211-2224 , 文章类型: Article,,卷期:2009年174-6]
- Immune responses were assessed at the single-cell level in lymph nodes from children with tuberculous lymphadenitis. Tuberculosis infection was associated with tissue remodeling of lymph nodes as well as altered cellular...
- Establishment of Experimental Eosinophilic Vasculitis by IgE-Mediated Cutaneous Reverse Passive Arthus Reaction
[作者:Ishii, T; Fujita, T; Matsushita, T; Yanaba, K; Hasegawa, M; Nakashima, H; Ogawa, F; Shimizu, K; Takehara, K; Tedder, TF; Sato, S; Fujimoto, M,期刊:American Journal of Pathology, 页码:2225-2233 , 文章类型: Article,,卷期:2009年174-6]
- Prominent eosinophil infiltration is a characteristic of some forms of vasculitis, such as Churg-Strauss syndrome, also known as allergic granulomatous vasculitis. In the current study, we established a mouse model of cu...
- Synthetic Retinoid AM80 Inhibits Th17 Cells and Ameliorates Experimental Autoimmune Encephalomyelitis
[作者:Klemann, C; Raveney, BJE; Klemann, AK; Ozawa, T; von Horsten, S; Shudo, K; Oki, S; Yamamura, T,期刊:American Journal of Pathology, 页码:2234-2245 , 文章类型: Article,,卷期:2009年174-6]
- Recent evidence suggests that interleukin-17-producing CD4(+) T cells (Th17 cells) are the dominant pathogenic cellular component in autoimmune inflammatory diseases, including multiple sclerosis. It has recently been de...
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