- Discovery and Structure-Activity Relationship of P1-P3 Ketoamide Derived Macrocyclic Inhibitors of Hepatitis C Virus NS3 Protease.
[作者:Venkatraman, Srikanth;Velazquez, Francisco;Wu, Wanli;Blackman, Melissa;Chen, Kevin X.;Bogen, Stephane;Nair, Latha;Tong, Xiao;Chase, Robert;Hart, Andrea;Agrawal, Sony;Pichardo, John;Prongay, Andrew;Cheng, Kuo-Chi;Girijavallabhan, Viyyoor;Piwinski, John;Shi,期刊:Journal of Medicinal Chemistry, 页码:336-346 , 文章类型: 研究论文,,卷期:2009年52-2]
- Hepatitis C virus (HCV) infection is the major cause of chronic liver disease, leading to cirrhosis and hepatocellular carcinoma, and affects more than 200 million people worldwide. Although combination therapy of inter...
- Codrugs Linking L-Dopa and Sulfur-Containing Antioxidants: New Pharmacological Tools against Parkinson's Disease.
[作者:Pinnen, Francesco;Cacciatore, Ivana;Cornacchia, Catia;Sozio, Piera;Cerasa, Laura Serafina;Iannitelli, Antonio;Nasuti, Cinzia;Cantalamessa, Franco;Sekar, Durairaj;Gabbianelli, Rosita;Falcioni, Maria Letizia;Di Stefano, Antonio;,期刊:Journal of Medicinal Chemistry, 页码:559-563 , 文章类型: 研究论文,,卷期:2009年52-2]
- A series of multifunctional codrugs (1-6) were synthesized to overcome the pro-oxidant effect assocd. with L-dopa (LD) therapy. Target compds. release LD and dopamine (DA) in human plasma after enzymic hydrolysis, displ...
- Iron Chelators of the Dipyridylketone Thiosemicarbazone Class: Precomplexation and Transmetalation Effects on Anticancer Activity.
[作者:Bernhardt, Paul V.;Sharpe, Philip C.;Islam, Mohammad;Lovejoy, David B.;Kalinowski, Danuta S.;Richardson, Des R.;,期刊:Journal of Medicinal Chemistry, 页码:407-415 , 文章类型: 研究论文,,卷期:2009年52-2]
- We previously reported a series of di-2-pyridylketone thiosemicarbazone (HDpT) chelators that showed marked and selective antitumor activity. To further understand their biol. efficacy, we report the characterization an...
- Identification of a New G-Quadruplex Motif in the KRAS Promoter and Design of Pyrene-Modified G4-Decoys with Antiproliferative Activity in Pancreatic Cancer Cells.
[作者:Cogoi, Susanna;Paramasivam, Manikandan;Filichev, Vyacheslav;Geci, Imrich;Pedersen, Erik B.;Xodo, Luigi E.;,期刊:Journal of Medicinal Chemistry, 页码:564-568 , 文章类型: 研究论文,,卷期:2009年52-2]
- A new quadruplex motif located in the promoter of the human KRAS gene, within a nuclease hypersensitive element (NHE), has been characterized. Oligonucleotides mimicking this quadruplex are found to compete with a DNA-p...
- Synthesis and Biological Activity of Human Neuropeptide S Analogues Modified in Position 5: Identification of Potent and Pure Neuropeptide S Receptor Antagonists.
[作者:Guerrini, Remo;Camarda, Valeria;Trapella, Claudio;Calo, Girolamo;Rizzi, Anna;Ruzza, Chiara;Fiorini, Stella;Marzola, Erika;Reinscheid, Rainer K.;Regoli, Domenico;Salvadori, Severo;,期刊:Journal of Medicinal Chemistry, 页码:524-529 , 文章类型: 研究论文,,卷期:2009年52-2]
- Neuropeptide S (SFRNGVGTGMKKTSFQRAKS; NPS), the endogenous ligand of a previously orphan receptor now named NPSR, regulates various biol. functions in the brain, including arousal, locomotion, anxiety, and food intake. ...
- Photodynamic Molecular Beacon Triggered by Fibroblast Activation Protein on Cancer-Associated Fibroblasts for Diagnosis and Treatment of Epithelial Cancers.
[作者:Lo, Pui-Chi;Chen, Juan;Stefflova, Klara;Warren, Michael S.;Navab, Roya;Bandarchi, Bizhan;Mullins, Stefanie;Tsao, Ming;Cheng, Jonathan D.;Zheng, Gang;,期刊:Journal of Medicinal Chemistry, 页码:358-368 , 文章类型: 研究论文,,卷期:2009年52-2]
- Fibroblast activation protein (FAP) is a cell-surface serine protease highly expressed on cancer-assocd. fibroblasts of human epithelial carcinomas but not on normal fibroblasts, normal tissues, and cancer cells. We rep...
- Synthesis, Oxidant Properties, and Antitumoral Effects of a Heteroleptic Palladium(II) Complex of Curcumin on Human Prostate Cancer Cells.
[作者:Valentini, Alessandra;Conforti, Franco;Crispini, Alessandra;De Martino, Angelo;Condello, Rossella;Stellitano, Chiara;Rotilio, Giuseppe;Ghedini, Mauro;Federici, Giorgio;Bernardini, Sergio;Pucci, Daniela;,期刊:Journal of Medicinal Chemistry, 页码:484-491 , 文章类型: 研究论文,,卷期:2009年52-2]
- A new ionic Pd(II) complex, [(bipy)Pd(Pcurc)][CF3SO3], 1, with the metal center coordinated to two different chelating ligands, the pure curcumin (Pcurc) and the 4,4'-dinonyl-2,2'-bipyridine (bipy), has been synthesized,...
|