- Structural requirements for activation of the 5-Oxo-6E, 8Z, 11Z, 14Z-eicosatetraenoic acid (5-Oxo-ETE) receptor: Identification of a mead acid metabolite with potent agonist activity
[作者:Patel, P; Cossette, C; Anumolu, JR; Gravel, S; Lesimple, A; Mamer, OA; Rokach, J; Powell, WS,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:698-707 , 文章类型: Article,,卷期:2008年325-2]
The 5-lipoxygenase product 5-oxo-6E, 8Z, 11Z, 14Z-eicosatetraenoic acid ( 5-oxo-ETE) is a potent chemoattractant for neutrophils and eosinophils, and its actions are mediated by the oxoeicosanoid ( OXE) receptor, a me...
- Food restriction alters N '-propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine dihydrochloride (pramipexole)-induced yawning, hypothermia, and locomotor activity in rats: Evidence for sensitization of dopamine D2 receptor-mediated effects
[作者:Collins, GT; Calinski, DM; Newman, AH; Grundt, P; Woods, JH,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:691-697 , 文章类型: Article,,卷期:2008年325-2]
Food restriction enhances sensitivity to the reinforcing effects of a variety of drugs of abuse including opiates, nicotine, and psychostimulants. Food restriction has also been shown to alter a variety of behavioral ...
- Prostaglandin I-2 plays a key role in zymosan-induced mouse pleurisy
[作者:Yuhki, KI; Ushikubi, F; Naraba, H; Ueno, A; Kato, H; Kojima, F; Narumiya, S; Sugimoto, Y; Matsushita, M; Oh-Ishi, S,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:601-609 , 文章类型: Article,,卷期:2008年325-2]
Zymosan, the cell wall of Saccharomyces cerevisiae, induces innate immune responses involving prostanoid production and complement activation. However, the roles of prostanoids in zymosan-induced inflammation and thei...
- Relation between mRNA expression level of multidrug resistance 1/ABCB1 in blood cells and required level of tacrolimus in pediatric living-donor liver transplantation
[作者:Goto, M; Masuda, S; Kiuchi, T; Ogura, Y; Oike, F; Tanaka, K; Uemoto, S; Inui, KI,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:610-616 , 文章类型: Article,,卷期:2008年325-2]
It has been difficult to set an individualized therapeutic window of tacrolimus after organ transplantation, because of wide interindividual variation of responsiveness to immunosuppressive therapy. In this study, we ...
- beta-phenylethylamine alters monoamine transporter function via trace amine-associated receptor 1: Implication for modulatory roles of trace amines in brain
[作者:Xie, ZH; Miller, GM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:617-628 , 文章类型: Article,,卷期:2008年325-2]
Brain monoamines include common biogenic amines (dopamine, norepinephrine, and serotonin) and trace amines [beta-phenylethylamine (beta-PEA), tyramine, tryptamine, and octopamine]. Common biogenic amines are well esta...
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