- Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease
[作者:Begum, AN; Jones, MR; Lim, GP; Morihara, T; Kim, P; Heath, DD; Rock, CL; Pruitt, MA; Yang, FS; Hudspeth, B; Hu, SX; Faull, KF; Teter, B; Cole, GM; Frautschy, SA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:196-208 , 文章类型: Article,,卷期:2008年326-1]
Curcumin can reduce inflammation and neurodegeneration, but its chemical instability and metabolism raise concerns, including whether the more stable metabolite tetrahydrocurcumin (TC) may mediate efficacy. We examine...
- Evidence for the role of metabotropic glutamate (mGlu)2 not mGlu3 receptors in the preclinical antipsychotic pharmacology of the mGlu2/3 receptor agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY404039)
[作者:Fell, MJ; Svensson, KA; Johnson, BG; Schoepp, DD,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:209-217 , 文章类型: Article,,卷期:2008年326-1]
(-)-(1R, 4S, 5S, 6S)-4-Amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY404039) is a potent and selective group II metabotropic glutamate [(mGlu) 2 and mGlu3] receptor agonist for which its prodrug LY2140...
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