- A long-acting and highly selective prostacyclin receptor agonist prodrug, 2-{4-[(5,6-diphenylpyrazin-2yl)(isopropyl) amino]butoxy}-N-(methylsulfonyl)acetamide(NS-304), ameliorates rat pulmonary hypertension with unique relaxant responses of its active form, {4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy} acetic acid (MRE-269), on rat pulmonary artery
[作者:Kuwano, K; Hashino, A; Noda, K; Kosugi, K; Kuwabara, K,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:691-699 , 文章类型: Article,,卷期:2008年326-3]
2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl) amino] butoxy}-N-(methylsulfonyl) acetamide (NS-304) is an orally available, long-acting nonprostanoid prostacyclin receptor (IP receptor) agonist prodrug. In a rat model of...
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