- Physiologically Based Pharmacokinetic Modeling to Predict Transporter-Mediated Clearance and Distribution of Pravastatin in Humans
[作者:Watanabe, T; Kusuhara, H; Maeda, K; Shitara, Y; Sugiyama, Y,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:652-662 , 文章类型: Article,,卷期:2009年328-2]
Hepatobiliary excretion mediated by transporters, organic anion-transporting polypeptide (OATP) 1B1 and multidrug resistance-associated protein (MRP) 2, is the major elimination pathway of an HMG-CoA reductase inhibit...
- N-(2-Hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide (PF-03716556), a Novel, Potent, and Selective Acid Pump Antagonist for the Treatment of Gastroesophageal Reflux Disease
[作者:Mori, H; Tonai-Kachi, H; Ochi, Y; Taniguchi, Y; Ohshiro, H; Takahashi, N; Aihara, T; Hirao, A; Kato, T; Sakakibara, M; Kurebayashi, Y,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:671-679 , 文章类型: Article,,卷期:2009年328-2]
Inhibition of H+,K+-ATPase is accepted as the most effective way of controlling gastric acid secretion. However, current acid suppressant therapy for gastroesophageal reflux disease, using histamine H 2 receptor antag...
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