- Tags for labeling protein N-termini with subtiligase for proteomics
[作者:Yoshihara, HAI; Mahrus, S; Wells, JA,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:6000-6003 , 文章类型: Article,,卷期:2008年18-22]
- The peptide ligase subtiligase, derived from subtilisin, has been employed in the identification of protein N-termini in complex mixtures. Here, the peptide ester substrates for the ligation reaction were optimized with ...
- A promiscuous aminoacyl-tRNA synthetase that incorporates cysteine, methionine, and alanine homologs into proteins
[作者:Brustad, E; Bushey, ML; Brock, A; Chittuluru, J; Schultz, PG,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:6004-6006 , 文章类型: Article,,卷期:2008年18-22]
- A mutant Escherichia coli leucyl-tRNA synthetase has been evolved for the selective incorporation of the methionine homolog 1 into proteins in yeast. This single aminoacyl-tRNA synthetase is capable of charging an amber ...
- Crystal structure of chemically synthesized HIV-1 protease and a ketomethylene isostere inhibitor based on the p2/NC cleavage site (Reprinted from Bioorg. Med. Chem. Lett., vol 18, pg 4554-4557, 2008)
[作者:Torbeev, VY; Mandal, K; Terechko, VA; Kent, SBH,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:6012-6015 , 文章类型: Reprint,,卷期:2008年18-22]
- Here we report the X-ray structures of chemically synthesized HIV-1 protease and the inactive [D25N] HIV-1 protease complexed with the ketomethylene isostere inhibitor Ac-Thr-Ile-Nle psi[CO-CH2]Nle-Gln-Arg.amide at 1.4 a...
- Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase
[作者:Slaymaker, IM; Bracey, M; Mileni, M; Garfunkle, J; Cravatt, BF; Boger, DL; Stevens, RC,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:5847-5850 , 文章类型: Article,,卷期:2008年18-22]
- The melting curves of fatty acid amide hydrolase (FAAH) in the presence of 29 reversible inhibitors were measured using a thiol-reactive fluorophore. The thermal stability (T-m) of the FAAH/inhibitor complex varied signi...
- Synthesis of macrocyclic trypanosomal cysteine protease inhibitors
[作者:Chen, YT; Lira, R; Hansell, E; McKerrow, JH; Roush, WR,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:5860-5863 , 文章类型: Article,,卷期:2008年18-22]
- The importance of cysteine proteases in parasites, compounded with the lack of redundancy compared to their mammalian hosts makes proteases attractive targets for the development of new therapeutic agents. The binding mo...
- A highly sensitive fluorogenic probe for cytochrome P450 activity in live cells
[作者:Yatzeck, MM; Lavis, LD; Chao, TY; Chandran, SS; Raines, RT,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:5864-5866 , 文章类型: Article,,卷期:2008年18-22]
- A derivative of rhodamine 110 has been designed and assessed as a probe for cytochrome P450 activity. This probe is the first to utilize a 'trimethyl lock' that is triggered by cleavage of an ether bond. In vitro, fluore...
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