- Human Equilibrative Nucleoside Transporter 1 Levels Predict Response to Gemcitabine in Patients With Pancreatic Cancer
[作者:Farrell, JJ; Elsaleh, H; Garcia, M; Lai, R; Ammar, A; Regine, WF; Abrams, R; Benson, AB; MacDonald, J; Cass, CE; Dicker, AP; Mackey, JR,期刊:Gastroenterology, 页码:187-195 , 文章类型: Article,,卷期:2009年136-1]
- Background & Aims: The human equilibrative nucleoside transporter (hENT1) protein transports gemcitabine into cells. Small retrospective studies in pancreatic cancer suggest that levels of hENT1 protein or messenger RNA ...
- P16(INK4a) Is a beta-Catenin Target Gene and Indicates Low Survival in Human Colorectal Tumors
[作者:Wassermann, S; Scheel, SK; Hiendlmeyer, E; Palmovist, R; Horst, D; Hlubek, F; Haynl, A; Kriegl, L; Reu, S; Merkel, S; Brabletz, T; Kirchner, T; Jung, A,期刊:Gastroenterology, 页码:196-205 , 文章类型: Article,,卷期:2009年136-1]
- Background & Aims: Human colorectal. carcinomas display an infiltrative front of invasion where tumor cells undergo an epithelomesenchymal transition associated with low survival. Epithelomesenchymal transition is regula...
- Decreased Expression of the RAS-GTPase Activating Protein RASAL1 Is Associated With Colorectal Tumor Progression
[作者:Ohta, M; Seto, M; Ijichi, H; Miyabayashi, K; Kudo, Y; Mohri, D; Asaoka, Y; Tada, M; Tanaka, Y; Ikenoue, T; Kanai, F; Kawabe, T; Omata, M,期刊:Gastroenterology, 页码:206-216 , 文章类型: Article,,卷期:2009年136-1]
- Background & Aims: Although colorectal cancer (CRC) progression has been associated with alterations in KRAS and RAS signaling, not all CRC cells have KRAS gene mutations. RAS activity is modulated by RAS-GTPase-activati...
- The ErbB4 Growth Factor Receptor Is Required for Colon Epithelial Cell Survival in the Presence of TNF
[作者:Frey, MR; Edelblum, KL; Mullane, MT; Liang, D; Polk, DB,期刊:Gastroenterology, 页码:217-226 , 文章类型: Article,,卷期:2009年136-1]
- Background & Aims: The ErbB4 receptor tyrosine kinase regulates cell growth, survival, and differentiation in several tissues, but its role in the gastrointestinal tract has not been reported. We tested the hypothesis th...
- Squamous Overgrowth Is Not a Safety Concern for Photodynamic Therapy for Barrett's Esophagus With High-Grade Dysplasia
[作者:Bronner, MP; Overholt, BF; Taylor, SL; Haggitt, RC; Wang, KK; Burdick, JS; Lightdale, CJ; Kimmey, M; Nava, HR; Sivak, MV; Nishioka, N; Barr, H; Canto, MI; Marcon, N; Pedrosa, M; Grace, M; Depot, M,期刊:Gastroenterology, 页码:56-64 , 文章类型: Article,,卷期:2009年136-1]
- Background & Aims: Photodynamic therapy with porfimer sodium combined with acid suppression (PHOPDT) is used to treat patients with Barretes esophagus (BE) with high-grade dysplasia (HGD). A 5-year phase 3 trial was cond...
- Folate Deficiency Induces Genomic Uracil Misincorporation and Hypomethylation But Does Not Increase DNA Point Mutations
[作者:Linhart, HG; Troen, A; Bell, GW; Cantu, E; Chao, WH; Moran, E; Steine, E; He, T; Jaenisch, R,期刊:Gastroenterology, 页码:227-235 , 文章类型: Article,,卷期:2009年136-1]
- Background and Aims: Epidemiologic studies have linked nutritional folate deficiency to an increased risk of cancer, but recent trials suggest that folate supplementation does not protect against tumor formation. Our aim...
- Presentation and Long-Term Follow-up of Refractory Celiac Disease: Comparison of Type I With Type II
[作者:Malamut, G; Afchain, P; Verkarre, V; Lecomte, T; Amiot, A; Damotte, D; Bouhnik, Y; Colombel, JF; Delchier, JC; Allez, M; Cosnes, J; Lavergne-Slove, A; Meresse, B; Trinquart, L; Macintyre, E; Radford-Weiss, I; Hermine, O; Brousse, N; Cerf-Bensussan, N; Cellier, C,期刊:Gastroenterology, 页码:81-90 , 文章类型: Article,,卷期:2009年136-1]
- Background & Aims: Refractory celiac disease (RCD) was recently subdivided into 2 subtypes (RCD I and 11) based on a normal or abnormal phenotype of intraepithelial lymphocytes (IELs), respectively. It is not clear, howe...
- Helicobacter pylori Dysregulation of Gastric Epithelial Tight Junctions by Urease-Mediated Myosin II Activation
[作者:Wroblewski, LE; Shen, L; Ogden, S; Romero-Gallo, J; Lapierre, LA; Israel, DA; Turner, JR; Peek, RM,期刊:Gastroenterology, 页码:236-246 , 文章类型: Article,,卷期:2009年136-1]
- Background & Aims: Helicobacter pylori-induced gastritis predisposes to the development of gastric cancer. Increased epithelial tight junction permeability and alterations in apical-junctional complexes are also associat...
- Increased Risk for Non-Hodgkin Lymphoma in Individuals With Celiac Disease and a Potential Familial Association
[作者:Gao, Y; Kristinsson, SY; Goldin, LR; Bjorkholm, M; Caporaso, NE; Landgren, O,期刊:Gastroenterology, 页码:91-98 , 文章类型: Article,,卷期:2009年136-1]
- Background & Aims: Celiac disease (CD), a common digestive disease, is well known to be associated with excess non-Hodgkin lymphoma (NHL) risk. However, there are only limited data on risk in the current era of serologic...
- Clinical Staging and Survival in Refractory Celiac Disease: A Single Center Experience
[作者:Rubio-Tapia, A; Kelly, DG; Lahr, BD; Dogan, A; Wu, TT; Murray, JA,期刊:Gastroenterology, 页码:99-107 , 文章类型: Article,,卷期:2009年136-1]
- Background & Aims: Refractory celiac disease (RCD) occurs when both symptoms and intestinal damage persist or recur despite strict adherence to a glutenfree diet. In RCD, the immunophenotype of intraepithelial. lymphocyt...
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