- IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation
[作者：Ma, HL; Liang, S; Li, J; Napierata, L; Brown, T; Benoit, S; Senices, M; Gill, D; Dunussi-Joannopoulos, K; Collins, M; Nickerson-Nutter, C; Fouser, LA; Young, DA,期刊：Journal of clinical investigation, 页码：597-607 , 文章类型： Article，,卷期：2008年118-2]
- Psoriasis is a chronic skin disease resulting from the dysregulated interplay between keratinocytes and infiltrating immune cells. We report on a psoriasis-like disease model, which is induced by the transfer of CD4(+)CD...
- Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice
[作者：Rose, KL; Paixao-Cavalcante, D; Fish, J; Manderson, AP; Malik, TH; Bygrave, AE; Lin, T; Sacks, SH; Walport, MJ; Cook, HT; Botto, M; Pickering, MC,期刊：Journal of clinical investigation, 页码：608-618 , 文章类型： Article，,卷期：2008年118-2]
- The inflammatory kidney disease membranoproliferative glomerulonephritis type II (MPGN2) is associated with dysregulation. of the alternative pathway of complement activation. MPGN2 is characterized by the presence of co...
- Claudin-16 and claudin-19 interact and form a cation-selective tight junction complex
[作者：Hou, JH; Renigunta, A; Konrad, M; Gornes, AS; Schneeberger, EE; Paul, DL; Waldegger, S; Goodenough, DA,期刊：Journal of clinical investigation, 页码：619-628 , 文章类型： Article，,卷期：2008年118-2]
- Tight junctions (TJs) play a key role in mediating paracellular ion reabsorption in the kidney. Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is an inherited disorder caused by mutations in the...
- IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1
[作者：Suzuki, H; Moldoveanu, Z; Hall, S; Brown, R; Vu, HL; Novak, L; Julian, BA; Tomana, M; Wyatt, RJ; Edberg, JC; Alarcon, GS; Kimberly, RP; Tomino, Y; Mestecky, J; Novak, J,期刊：Journal of clinical investigation, 页码：629-639 , 文章类型： Article，,卷期：2008年118-2]
- Aberrant glycosylation of IgA1 plays an essential role in the pathogenesis of IgA nephropathy. This abnormality is manifested by a deficiency of galactose in the hinge-region O-linked glycans of IgA1. Biosynthesis of the...
- Erythropoietin: when liability becomes asset in neurovascular repair
[作者：Grant, MB; Boulton, ME; Ljubimov, AV,期刊：Journal of clinical investigation, 页码：467-470 , 文章类型： Editorial Material，,卷期：2008年118-2]
- Erythropoietin (Epo) leads to the proliferation and differentiation of erythroid precursors, but is also involved in diverse nonhematopoietic biological functions. In this issue of the JCI, Chen, Smith, and colleagues de...
- Stressed out: the skeletal muscle ryanodine receptor as a target of stress
[作者：Bellinger, AM; Mongillo, M; Marks, AR,期刊：Journal of clinical investigation, 页码：445-453 , 文章类型： Review，,卷期：2008年118-2]
- Over the past century, understanding the mechanisms underlying muscle fatigue and weakness has been the focus of much investigation. However, the dominant theory in the field, that lactic acidosis causes muscle fatigue, ...
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