- Malaria: progress, perils, and prospects for eradication
[作者:Greenwood, BM; Fidock, DA; Kyle, DE; Kappe, SHI; Alonso, PL; Collins, FH; Duffy, PE,期刊:Journal of clinical investigation, 页码:1266-1276 , 文章类型: Review,,卷期:2008年118-4]
- There are still approximately 500 million cases of malaria and 1 million deaths from malaria each year. Yet recently, malaria incidence has been dramatically reduced in some parts of Africa by increasing deployment of an...
- Enteric infections, diarrhea, and their impact on function and development
[作者:Petri, WA; Miller, M; Binder, HJ; Levine, MM; Dillingham, R; Guerrant, RL,期刊:Journal of clinical investigation, 页码:1277-1290 , 文章类型: Review,,卷期:2008年118-4]
- Enteric infections, with or without overt diarrhea, have profound effects on intestinal absorption, nutrition, and childhood development as well as on global mortality. Oral rehydration therapy has reduced the number of ...
- Pneumonia research to reduce childhood mortality in the developing world
[作者:Scott, JAG; Brooks, WA; Peiris, JSM; Holtzman, D; Mulhollands, EK,期刊:Journal of clinical investigation, 页码:1291-1300 , 文章类型: Review,,卷期:2008年118-4]
- Pneumonia is an illness, usually caused by infection, in which the lungs become inflamed and congested, reducing oxygen exchange and leading to cough and breathlessness. It affects individuals of all ages but occurs most...
- Kinetoplastids: related protozoan pathogens, different diseases
[作者:Stuart, K; Brun, R; Croft, S; Fairlamb, A; Gurtler, RE; McKerrow, J; Reed, S; Tarleton, R,期刊:Journal of clinical investigation, 页码:1301-1310 , 文章类型: Review,,卷期:2008年118-4]
- Kinetoplastids are a group of flagellated protozoans that include the species Trypanosoma and Leishmania, which are human pathogens with devastating health and economic effects. The sequencing of the genomes of some of t...
- Helminth infections: the great neglected tropical diseases
[作者:Hotez, PJ; Brindley, PJ; Bethony, JM; King, CH; Pearce, EJ; Jacobson, J,期刊:Journal of clinical investigation, 页码:1311-1321 , 文章类型: Review,,卷期:2008年118-4]
- Helminths are parasitic worms. They are the most common infectious agents of humans in developing countries and produce a global burden of disease that exceeds better-known conditions, including malaria and tuberculosis....
- New challenges in studying nutrition-disease interactions in the developing world
[作者:Prentice, AM; Gershwin, ME; Schaible, UE; Keusch, GT; Victora, CG; Gordon, JI,期刊:Journal of clinical investigation, 页码:1322-1329 , 文章类型: Review,,卷期:2008年118-4]
- Latest estimates indicate that nutritional deficiencies account for 3 million child deaths each year in less-developed countries. Targeted nutritional interventions could therefore save millions of lives. However, such i...
- As the world grows: contraception in the 21st century
[作者:Aitken, RJ; Baker, MA; Doncel, GF; Matzuk, MM; Mauck, CK; Harper, MJK,期刊:Journal of clinical investigation, 页码:1330-1343 , 文章类型: Review,,卷期:2008年118-4]
- Contraceptives that are readily available and acceptable are required in many poorer countries to reduce population growth and in all countries to prevent maternal morbidity and mortality arising from unintended pregnanc...
- A CD28 superagonistic antibody elicits 2 functionally distinct waves of T cell activation in rats
[作者:Muller, N; van den Brandt, J; Odoardi, F; Tischner, D; Herath, J; Flugel, A; Reichardt, HM,期刊:Journal of clinical investigation, 页码:1405-1416 , 文章类型: Article,,卷期:2008年118-4]
- Administration of the CD28 superagonistic antibody JJ316 is an efficient means to treat autoimmune diseases in rats, but the humanized antibody TGN1412 caused devastating side effects in healthy volunteers during a clini...
- IRF9 and STAT1 are required for IgG autoantibody production and B cell expression of TLR7 in mice
[作者:Thibault, DL; Chu, AD; Graham, KL; Balboni, I; Lee, LY; Kohlmoos, C; Landrigan, A; Higgins, JP; Tibshirani, R; Utz, PJ,期刊:Journal of clinical investigation, 页码:1417-1426 , 文章类型: Article,,卷期:2008年118-4]
- A hallmark of SLE is the production of high-titer, high-affinity, isotype-switched IgG autoantibodies directed against nucleic acid-associated antigens. Several studies have established a role for both type I IFN (IFN-I)...
- The efficacy of DNA vaccination is enhanced in mice by targeting the encoded protein to dendritic cells
[作者:Nchinda, G; Kuroiwa, J; Oks, M; Trumpfheller, C; Park, CG; Huang, Y; Hannaman, D; Schlesinger, SJ; Mizenina, O; Nussenzweig, MC; Uberla, K; Steinman, RM,期刊:Journal of clinical investigation, 页码:1427-1436 , 文章类型: Article,,卷期:2008年118-4]
- DNA vaccines promote an immune response by providing antigen-encoding DNA to the recipient, but the efficacy of such vaccines needs improving. Many approaches have considerable potential but currently induce relatively w...
- Targeted mutation of mouse skeletal muscle sodium channel produces myotonia and potassium-sensitive weakness
[作者:Hayward, LJ; Kim, JS; Lee, MY; Zhou, H; Kim, JW; Misra, K; Salajegheh, M; Wu, FF; Matsuda, C; Reid, V; Cros, D; Hoffman, EP; Renaud, JM; Cannon, SC; Brown, RH,期刊:Journal of clinical investigation, 页码:1437-1449 , 文章类型: Article,,卷期:2008年118-4]
- Hyperkalemic periodic paralysis (HyperKPP) produces myotonia and attacks of muscle weakness triggered by rest after exercise or by K+ ingestion. We introduced a missense substitution corresponding to a human familial Hyp...
- Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome
[作者:Rahmouni, K; Fath, MA; Seo, S; Thedens, DR; Berry, CJ; Weiss, R; Nishimura, DY; Sheffield, VC,期刊:Journal of clinical investigation, 页码:1458-1467 , 文章类型: Article,,卷期:2008年118-4]
- Bardet-Biedl syndrome (BBS) is a heterogeneous genetic disorder characterized by many features, including obesity and cardiovascular disease. We previously developed knockout mouse models of 3 BBS genes: BBS2, BBS4, and ...
- Neutrophil gelatinase-associated lipocalin mediates 13-cis retinoic acid-induced apoptosis of human sebaceous gland cells
[作者:Nelson, AM; Zhao, W; Gilliland, KL; Zaenglein, AL; Liu, WL; Thiboutot, DM,期刊:Journal of clinical investigation, 页码:1468-1478 , 文章类型: Article,,卷期:2008年118-4]
- 13-cis retinoic acid (13-cis RA; also known as isotretinoin) is the most potent agent available for treatment of acne. It is known that the drug induces apoptosis in cells cultured from human sebaceous glands, but its me...
- Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism
[作者:Welsh, M; Saunders, PTK; Fisken, M; Scott, HM; Hutchison, GR; Smith, LB; Sharpe, RM,期刊:Journal of clinical investigation, 页码:1479-1490 , 文章类型: Article,,卷期:2008年118-4]
- Becoming a phenotypic male is ultimately determined by androgen-induced masculinization. Disorders of fetal masculinization, resulting in hypospadias or cryptorchidism, are common, but their cause remains unclear. Togeth...
- Excess adenosine in murine penile erectile tissues contributes to priapism via A(2B) adenosine receptor signaling
[作者:Mi, T; Abbasi, S; Zhang, H; Uray, K; Chunn, JL; Xia, LW; Molina, JG; Weisbrodt, NW; Kellems, RE; Blackburn, MR; Xia, Y,期刊:Journal of clinical investigation, 页码:1491-1501 , 文章类型: Article,,卷期:2008年118-4]
- Priapism, abnormally prolonged penile erection in the absence of sexual excitation, is associated with ischemia-mediated erectile tissue damage and subsequent erectile dysfunction. It is common among males with sickle ce...
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