- Developing recombinant HPA-1a-specific antibodies with abrogated Fc gamma receptor binding for the treatment of fetomaternal alloimmune thrombocytopenia
[作者:Ghevaert, C; Wilcox, DA; Fang, J; Armour, KL; Clark, MR; Ouwehand, WH; Williamson, LM,期刊:Journal of clinical investigation, 页码:2929-2938 , 文章类型: Article,,卷期:2008年118-8]
- Fetomaternal alloinimune thrombocytopenia (FMAIT) is caused by maternal generation of antibodies specific for paternal platelet antigens and can lead to fetal intracranial hemorrhage. A SNP in the gene encoding integrin ...
- Helicobacter pylori eradication shifts monocyte Fc gamma receptor balance toward inhibitory Fc gamma RIIB in immune thrombocytopenic purpura patients
[作者:Asahi, A; Nishimoto, T; Okazaki, Y; Suzuki, H; Masaoka, T; Kawakami, Y; Ikeda, Y; Kuwana, M,期刊:Journal of clinical investigation, 页码:2939-2949 , 文章类型: Article,,卷期:2008年118-8]
- Immune thrombocytopenia purpura (ITP) is a bleeding disorder in which platelet-specific autoantibodies cause a loss of platelets. In a subset of patients with ITP and infected with Helicobacter pylori, the number of plat...
- The cholinesterase-like domain of thyroglobulin functions as an intramolecular chaperone
[作者:Lee, J; Di Jeso, B; Arvan, P,期刊:Journal of clinical investigation, 页码:2950-2958 , 文章类型: Article,,卷期:2008年118-8]
- Thyroid hormonogenesis requires secretion of thyroglobulin, a protein comprising Cys-rich regions I, II, and III (referred to collectively as region I-II-III) followed by a cholinesterase-like (ChEL) domain. Secretion of...
- Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats
[作者:Ono, H; Pocai, A; Wang, YH; Sakoda, H; Asano, T; Backer, JM; Schwartz, GJ; Rossetti, L,期刊:Journal of clinical investigation, 页码:2959-2968 , 文章类型: Article,,卷期:2008年118-8]
- Prolonged activation of p70 S6 kinase (S6K) by insulin and nutrients leads to inhibition of insuhn signaling via negative feedback input to the signaling factor IRS-1. Systemic deletion of S6K protects against diet-induc...
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