- Bronsted Acid-Catalyzed, Enantioselective, Vinylogous Mannich Reaction of Vinylketene Silyl N,O-Acetals.
[作者:Giera, David S.;Sickert, Marcel;Schneider, Christoph;,期刊:Organic Letters, 页码:4259-4262 , 文章类型: 研究论文,,卷期:2008年10-19]
- Vinylketene silyl N,O-acetals, e.g. I, undergo chiral phosphoric acid-catalyzed, vinylogous Mukaiyama-Mannich reactions with imines and afford d-amino-a,b-unsatd. amides, e.g. II, in typically good yields, complete g-reg...
- Improved Synthesis of the Epoxy Isoprostane Phospholipid PEIPC and its Reactivity with Amines.
[作者:Jung, Michael E.;Berliner, Judith A.;Koroniak, Lukasz;Gugiu, B. Gabriel;Watson, Andrew D.;,期刊:Organic Letters, 页码:4207-4209 , 文章类型: 研究论文,,卷期:2008年10-19]
- An improved synthesis of the naturally occurring hydroxy ketone 1-palmitoyl-2-(5,6)-epoxyisoprostane E2-sn-glycero-3-phosphocholine (PEIPC), a compd. that plays a role in endothelial activation in atherosclerosis, has be...
- Total Synthesis of (-)-Aplaminal.
[作者:Smith, Amos B., III;Liu, Zhuqing;,期刊:Organic Letters, 页码:4363-4365 , 文章类型: 研究论文,,卷期:2008年10-19]
- The total synthesis and assignment of abs. configuration of (-)-aplaminal (I), a cytotoxic metabolite from a sea hare possessing a triazobicyclo[3.2.1]octane skeleton, has been achieved. The synthesis entailed condensat...
- Pd(OAc)2-Catalyzed cyclization of 2,3-allenoic acids in the presence of terminal a,b-unsaturated alkynones: a one-pot highly stereoselective synthesis of 4-(3'-oxo-1'(E)-alkenyl)-2(5H)-furanones.
[作者:Chen, Guofei;Zeng, Rong;Gu, Zhenhua;Fu, Chunling;Ma, Shengming;,期刊:Organic Letters, 页码:4235-4238 , 文章类型: 研究论文,,卷期:2008年10-19]
- The Pd(OAc)2-catalyzed cyclization reaction of 2,3-allenoic acids in the presence of terminal a,b-unsatd. alkynones afforded an E/Z mixt. of 4-(3'-oxo-1'-alkenyl)-2(5H)-furanones. A subsequent complete isomerization of ...
- A Two-Directional Approach to Enantiopure 1,4-Difluoro-cyclohexenes: Synthesis of Difluorinated Cyclitol Analogs.
[作者:Purser, Sophie;Claridge, Timothy D. W.;Odell, Barbara;Moore, Peter R.;Gouverneur, Veronique;,期刊:Organic Letters, 页码:4263-4266 , 文章类型: 研究论文,,卷期:2008年10-19]
- Enantiopure 1,4-difluoro-cyclohexenes were prepd. from readily available acetonide-protected (3S,4S)-hexa-1,5-diene-3,4-diol. In a two-directional mode, a double cross-metathesis reaction using allyltrimethylsilane as t...
- Regioselective Esterification of Vicinal Diols on Monosaccharide Derivatives via Mitsunobu Reactions.
[作者:Wang, Guijun;Ella-Menye, Jean-Rene;St. Martin, Michael;Yang, Hao;Williams, Kristopher;,期刊:Organic Letters, 页码:4203-4206 , 文章类型: 研究论文,,卷期:2008年10-19]
- alcs. derived from D-glucose, D-mannose, and D-galactose via the Mitsunobu reaction. The benzoylation reaction of vicinal diols derived from monosaccharides under Mitsunobu conditions afforded monobenzoates with retenti...
- Cyclic Imine Nitro-Mannich/Lactamization Cascades: A Direct Stereoselective Synthesis of Multicyclic Piperidinone Derivatives.
[作者:Jakubec, Pavol;Helliwell, Madeleine;Dixon, Darren J.;,期刊:Organic Letters, 页码:4267-4270 , 文章类型: 研究论文,,卷期:2008年10-19]
- An efficient nitro-Mannich/lactamization cascade of g-nitro esters I and II with cyclic imines, e.g. III (R1 = R2 = H, OMe; R1 = NO2, R2 = H), for the prepn. of architecturally complex multicyclic piperidinone ring-contg...
- Structural Determination of Montanacin D by Total Synthesis.
[作者:Takahashi, Shunya;Hongo, Yayoi;Tsukagoshi, Yuki;Koshino, Hiroyuki;,期刊:Organic Letters, 页码:4223-4226 , 文章类型: 研究论文,,卷期:2008年10-19]
- The first total syntheses of acetogenin I and its 4S,8R-isomer are described. The key step involves intermol. metathesis of an a,b-unsatd. ketone carrying a tetrahydropyranyl lactone with a THF deriv. Compd. I has spec...
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