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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共41条记录   Thiophene Bioisosteres of Spirocyclic s Receptor Ligands. 1. [作者：N-Substituted Spiro[piperidine-4,4'-thieno[3,2-c]pyrans]. Oberdorf, Christoph;Schepmann, Dirk;Vela, Jose Miguel;Diaz, Jose Luis;Holenz, Joerg;Wuesch, Bernhard;,期刊：Journal of Medicinal Chemistry, 页码：6531-6537 , 文章类型： 研究论文，,卷期：2008年51-20] (Heterocyclic Compounds (More Than One Hetero Atom)) Section Herein, the synthesis and pharmacol. evaluation of thiophene bioisosteres I (R = n-Bu, n-C5H11, cyclohexylmethyl, Ph(CH2)4, 4-MeOC6H4CH2, 2-thienylmethyl, EtO2... Efficient synthesis and neuroprotective effect of substituted 1,3-diphenyl-2-propen-1-ones. [Erratum to document cited in CA149:128604]. [作者：Jung, Jae-Chul;Jang, Soyong;Lee, Yongnam;Min, Dongguk;Lim, Eunyoung;Jung, Heyin;Oh, Miyeon;Oh, Seikwan;Jung, Mankil;,期刊：Journal of Medicinal Chemistry, 页码：6620-6620 , 文章类型： 研究论文，,卷期：2008年51-20] 1, 22 On page 4058, ref. 1 was incomplete. The correct ref. is given. Differences between High- and Low-Affinity Complexes of Enzymes and Nonenzymes. [作者：Carlson, Heather A.;Smith, Richard D.;Khazanov, Nickolay A.;Kirchhoff, Paul D.;Dunbar, James B.;Benson, Mark L.;,期刊：Journal of Medicinal Chemistry, 页码：6432-6441 , 文章类型： 研究论文，,卷期：2008年51-20] Phys. differences in small mol. binding between enzymes and nonenzymes were found through mining the protein-ligand database, Binding MOAD (Mother of All Databases). The data suggest that divergent approaches may be mor... Solution Kinetics Measurements Suggest HIV-1 Protease Has Two Binding Sites for Darunavir and Amprenavir. [作者：Kovalevsky, Andrey Y.;Ghosh, Arun K.;Weber, Irene T.;,期刊：Journal of Medicinal Chemistry, 页码：6599-6603 , 文章类型： 研究论文，,卷期：2008年51-20] Darunavir, a potent antiviral drug, showed an unusual second binding site on the HIV-1 protease dimer surface of the V32I drug resistant mutant and normal binding in the active site cavity. Kinetic anal. for wild type a... 3-Amino-7-phthalazinylbenzoisoxazoles as a Novel Class of Potent, Selective, and Orally Available Inhibitors of p38a Mitogen-Activated Protein Kinase. [作者：Pettus, Liping H.;Xu, Shimin;Cao, Guo-Qiang;Chakrabarti, Partha P.;Rzasa, Robert M.;Sham, Kelvin;Wurz, Ryan P.;Zhang, Dawei;Middleton, Scott;Henkle, Bradley;Plant, Matthew H.;Saris, Christiaan J. M.;Sherman, Lisa;Wong, Lu Min;Powers, David A.;Tudor, Yanya,期刊：Journal of Medicinal Chemistry, 页码：6280-6292 , 文章类型： 研究论文，,卷期：2008年51-20] The p38 mitogen-activated protein kinase (MAPK) is a central signaling mol. in many proinflammatory pathways, regulating the cellular response to a multitude of external stimuli including heat, UV radiation, osmotic shoc... Soluble 3',6-Substituted Indirubins with Enhanced Selectivity toward Glycogen Synthase Kinase-3 Alter Circadian Period. [作者：Vougogiannopoulou, Konstantina;Ferandin, Yoan;Bettayeb, Karima;Myrianthopoulos, Vassilios;Lozach, Olivier;Fan, Yunzhen;Johnson, Carl Hirschie;Magiatis, Prokopios;Skaltsounis, Alexios-Leandros;Mikros, Emmanuel;Meijer, Laurent;,期刊：Journal of Medicinal Chemistry, 页码：6421-6431 , 文章类型： 研究论文，,卷期：2008年51-20] numerous physiol. events and in major diseases, such as Alzheimer's disease, diabetes, and cardiac hypertrophy. Indirubins are bis-indoles that can be generated from various natural sources or chem. synthesized. While ... Toward Optimization of the Linker Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies. [作者：Johnson, Steven M.;Connelly, Stephen;Wilson, Ian A.;Kelly, Jeffery W.;,期刊：Journal of Medicinal Chemistry, 页码：6348-6358 , 文章类型： 研究论文，,卷期：2008年51-20] To develop potent and highly selective transthyretin (TTR) amyloidogenesis inhibitors, it is useful to systematically optimize the three substructural elements that compose a typical TTR kinetic stabilizer: the two aryl ... Blocking Estrogen Signaling After the Hormone: Pyrimidine-Core Inhibitors of Estrogen Receptor-Coactivator Binding. [作者：Parent, Alexander A.;Gunther, Jillian R.;Katzenellenbogen, John A.;,期刊：Journal of Medicinal Chemistry, 页码：6512-6530 , 文章类型： 研究论文，,卷期：2008年51-20] have developed small mols. that directly disrupt the key estrogen receptor (ER)/coactivator interaction necessary for gene activation. The more direct, protein-protein nature of this disruption might be effective even in... Target Flexibility: An Emerging Consideration in Drug Discovery and Design. [作者：Cozzini, Pietro;Kellogg, Glen E.;Spyrakis, Francesca;Abraham, Donald J.;Costantino, Gabriele;Emerson, Andrew;Fanelli, Francesca;Gohlke, Holger;Kuhn, Leslie A.;Morris, Garrett M.;Orozco, Modesto;Pertinhez, Thelma A.;Rizzi, Menico;Sotriffer, Christoph A.;,期刊：Journal of Medicinal Chemistry, 页码：6237-6255 , 文章类型： 综述，,卷期：2008年51-20] A review.