- Design, Synthesis, and Biological Evaluation of Novel Aminobisphosphonates Possessing an in Vivo Antitumor Activity Through a gd-T Lymphocytes-Mediated Activation Mechanism.
[作者:Simoni, Daniele;Gebbia, Nicola;Invidiata, Francesco Paolo;Eleopra, Marco;Marchetti, Paolo;Rondanin, Riccardo;Baruchello, Riccardo;Provera, Stefano;Marchioro, Carla;Tolomeo, Manlio;Marinelli, Luciana;Limongelli, Vittorio;Novellino, Ettore;Kwaasi, Aaron;Dun,期刊:Journal of Medicinal Chemistry, 页码:6800-6807 , 文章类型: 研究论文,,卷期:2008年51-21]
- (Organometallic and Organometalloidal Compounds) Section A small series of aminobisphosphonates (N-BPs) structurally related to zoledronic acid was synthesized with the aim of improving activity toward activation of huma...
- Spirocyclic Benzopyran-Based Derivatives as New Anti-ischemic Activators of Mitochondrial ATP-Sensitive Potassium Channel.
[作者:Breschi, Maria C.;Calderone, Vincenzo;Digiacomo, Maria;Manganaro, Mariaelisa;Martelli, Alma;Minutolo, Filippo;Rapposelli, Simona;Testai, Lara;Tonelli, Federica;Balsamo, Aldo;,期刊:Journal of Medicinal Chemistry, 页码:6945-6954 , 文章类型: 研究论文,,卷期:2008年51-21]
- Heart mitochondrial ATP-sensitive potassium channels (mito-KATP channels) are deeply implicated in the self-defense mechanism of ischemic preconditioning. Therefore, exogenous mols. activating these channels are conside...
- Potent, Selective and Orally Bioavailable Dihydropyrimidine Inhibitors of Rho Kinase (ROCK1) as Potential Therapeutic Agents for Cardiovascular Diseases.
[作者:Sehon, Clark A.;Wang, Gren Z.;Viet, Andrew Q.;Goodman, Krista B.;Dowdell, Sarah E.;Elkins, Patricia A.;Semus, Simon F.;Evans, Christopher;Jolivette, Larry J.;Kirkpatrick, Robert B.;Dul, Edward;Khandekar, Sanjay S.;Yi, Tracey;Wright, Lois L.;Smith, Gary K.,期刊:Journal of Medicinal Chemistry, 页码:6631-6634 , 文章类型: 研究论文,,卷期:2008年51-21]
- Recent studies using known Rho-assocd. kinase isoform 1 (ROCK1) inhibitors along with cellular and mol. biol. data have revealed a pivotal role of this enzyme in many aspects of cardiovascular function. Here we report a...
- Discovery of an Orally Bioavailable Small Molecule Inhibitor of Prosurvival B-Cell Lymphoma 2 Proteins.
[作者:Park, Cheol-Min;Bruncko, Milan;Adickes, Jessica;Bauch, Joy;Ding, Hong;Kunzer, Aaron;Marsh, Kennan C.;Nimmer, Paul;Shoemaker, Alexander R.;Song, Xiaohong;Tahir, Stephen K.;Tse, Christin;Wang, Xilu;Wendt, Michael D.;Yang, Xiufen;Zhang, Haichao;Fesik, Stephe,期刊:Journal of Medicinal Chemistry, 页码:6902-6915 , 文章类型: 研究论文,,卷期:2008年51-21]
- been correlated with tumorigenesis and resistance to chemotherapy, and thus, the development of antagonists of these proteins may provide a novel means for the treatment of cancer. We recently described the discovery of...
- Design and Synthesis of a Novel Series of Pyranonaphthoquinones as Topoisomerase II Catalytic Inhibitors.
[作者:Jimenez-Alonso, Sandra;Chavez Orellana, Haydee;Estevez-Braun, Ana;Ravelo, Angel G.;Perez-Sacau, Elisa;Machin, Felix;,期刊:Journal of Medicinal Chemistry, 页码:6761-6772 , 文章类型: 研究论文,,卷期:2008年51-21]
- On the basis of previous pharmacophore modeling studies of naphthoquinones derivs., a new set of pyranonaphthoquinones, e. g. I, was designed and prepd. These compds. were obtained through a direct and highly efficient ...
- Virtual Screening to Successfully Identify Novel Janus Kinase 3 Inhibitors: A Sequential Focused Screening Approach.
[作者:Chen, Xin;Wilson, Lawrence J.;Malaviya, Ravi;Argentieri, Rochelle L.;Yang, Shyh-Ming;,期刊:Journal of Medicinal Chemistry, 页码:7015-7019 , 文章类型: 研究论文,,卷期:2008年51-21]
- In an effort to identify novel Janus kinase 3 inhibitors, a sequential focused screening approach was adopted to search our inhouse chem. database. By biol. testing only 79 selected compds., we successfully identified 1...
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