- Bacterial Infection of Smad3/Rag2 Double-Null Mice with Transforming Growth Factor-beta Dysregulation as a Model for Studying Inflammation-Associated Colon Cancer
[作者:Maggio-Price, L; Treuting, P; Bielefeldt-Ohmann, H; Seamons, A; Drivdahl, R; Zeng, WP; Lai, L; Huycke, M; Phelps, S; Brabb, T; Iritani, BM,期刊:American Journal of Pathology, 页码:317-329 , 文章类型: Article,,卷期:2009年174-1]
- Alterations in genes encoding transforming growth factor-beta-signaling components contribute to colon cancer in humans. Similarly, mice deficient in the transforming growth factor-beta signaling molecule, Smad3, develop...
- Disruption of Tissue-Specific Fucosyltransferase VII, an Enzyme Necessary for Selectin Ligand Synthesis, Suppresses Atherosclerosis in Mice
[作者:Gitlin, JM; Homeister, JW; Bulgrien, J; Counselman, J; Curtiss, LK; Lowe, JB; Boisvert, WA,期刊:American Journal of Pathology, 页码:343-350 , 文章类型: Article,,卷期:2009年174-1]
- A hallmark feature of atherosclerosis is that circulating mononuclear cells adhere to the endothelium, and migrate into the subendothelial space. This adhesion is mediated by molecules such as selectins that are expresse...
- Where Asthma and Hypersensitivity Pneumonitis Meet and Differ Noneosinophilic Severe Asthma
[作者:Bogaert, P; Tournoy, KG; Naessens, T; Grooten, J,期刊:American Journal of Pathology, 页码:3-13 , 文章类型: Review,,卷期:2009年174-1]
- Asthma is a type-I allergic airway disease characterized by Th-2 cells and IgE. Episodes of bronchial inflammation, eosinophilic in nature and promoting bronchoconstriction, may become chronic and lead to persistent resp...
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