- The Motor Complex of Plasmodium falciparum PHOSPHORYLATION BY A CALCIUM-DEPENDENT PROTEIN KINASE
[作者:Green, JL; Rees-Channer, RR; Howell, SA; Martin, SR; Knuepfer, E; Taylor, HM; Grainger, M; Holder, AA,期刊:Journal of Biological Chemistry, 页码:30980-30989 , 文章类型: Article,,卷期:2008年283-45]
- Calcium-dependent protein kinases (CDPKs) of Apicomplexan parasites are crucial for the survival of the parasite throughout its life cycle. CDPK1 is expressed in the asexual blood stages of the parasite, particularly lat...
- The Sushi Domains of Secreted GABA(B1) Isoforms Selectively Impair GABA(B) Heteroreceptor Function
[作者:Tiao, JY; Bradaia, A; Biermann, B; Kaupmann, K; Metz, M; Haller, C; Rolink, AG; Pless, E; Barlow, PN; Gassmann, M; Bettler, B,期刊:Journal of Biological Chemistry, 页码:31005-31011 , 文章类型: Article,,卷期:2008年283-45]
- GABA(B) receptors are the G-protein-coupled receptors for gamma-aminobutyric acid (GAB(A)), the main inhibitory neurotransmitter in the brain. GABA(B) receptors are promising drug targets for a wide spectrum of psychiatr...
- RhoA GTPase and F-actin Dynamically Regulate the Permeability of Cx43-made Channels in Rat Cardiac Myocytes
[作者:Derangeon, M; Bourmeyster, N; Plaisance, I; Pinet-Charvet, C; Chen, Q; Duthe, F; Popoff, MR; Sarrouilhe, D; Herve, JC,期刊:Journal of Biological Chemistry, 页码:30754-30765 , 文章类型: Article,,卷期:2008年283-45]
- Gap junctions are clusters of transmembrane channels allowing a passive diffusion of ions and small molecules between adjacent cells. Connexin43, the main channel-forming protein expressed in ventricular myocytes, can as...
- Entrapment of Carbon Dioxide in the Active Site of Carbonic Anhydrase II
[作者:Domsic, JF; Avvaru, BS; Kim, CU; Gruner, SM; Agbandje-McKenna, M; Silverman, DN; Mckenna, R,期刊:Journal of Biological Chemistry, 页码:30766-30771 , 文章类型: Article,,卷期:2008年283-45]
- The visualization at near atomic resolution of transient substrates in the active site of enzymes is fundamental to fully understanding their mechanism of action. Here we show the application of using CO2-pressurized, cr...
- The Organization of LH2 Complexes in Membranes from Rhodobacter sphaeroides
[作者:Olsen, JD; Tucker, JD; Timney, JA; Qian, P; Vassilev, C; Hunter, CN,期刊:Journal of Biological Chemistry, 页码:30772-30779 , 文章类型: Article,,卷期:2008年283-45]
- The mapping of the photosynthetic membrane of Rhodobacter sphaeroides by atomic force microscopy (AFM) revealed a unique organization of arrays of dimeric reaction center-light harvesting I-PufX (RC-LH1-PufX) core comple...
- Selective Targeting of Leukemic Cell Growth in Vivo and in Vitro Using a Gene Silencing Approach to Diminish S-Adenosylmethionine Synthesis
[作者:Attia, RR; Gardner, LA; Mahrous, E; Taxman, DJ; LeGros, L; Rowe, S; Ting, JPY; Geller, A; Kotb, M,期刊:Journal of Biological Chemistry, 页码:30788-30795 , 文章类型: Article,,卷期:2008年283-45]
- We exploited the fact that leukemic cells utilize significantly higher levels of S-adenosylmethionine (SAMe) than normal lymphocytes and developed tools that selectively diminished their survival under physiologic condit...
- A C-terminal Fragment of Cyclin E, Generated by Caspase-mediated Cleavage, Is Degraded in the Absence of a Recognizable Phosphodegron
[作者:Plesca, D; Mazumder, S; Gama, V; Matsuyama, S; Almasan, A,期刊:Journal of Biological Chemistry, 页码:30796-30803 , 文章类型: Article,,卷期:2008年283-45]
- We have previously shown that caspase-mediated cleavage of Cyclin E generates p18-Cyclin E in hematopoietic tumor cells. Its expression can induce apoptosis or sensitize to apoptotic stimuli in many cell types. However, ...
- The Structural Basis of Serpin Polymerization Studied by Hydrogen/Deuterium Exchange and Mass Spectrometry
[作者:Tsutsui, Y; Kuri, B; Sengupta, T; Wintrode, PL,期刊:Journal of Biological Chemistry, 页码:30804-30811 , 文章类型: Article,,卷期:2008年283-45]
- The serpinopathies are a group of inherited disorders that share as their molecular basis the misfolding and polymerization of serpins, an important class of protease inhibitors. Depending on the identity of the serpin, ...
- Post-transcriptional Control of CCAAT/Enhancer-binding Protein beta (C/EBP beta) Expression FORMATION OF A NUCLEAR HuR-C/EBP beta mRNA COMPLEX DETERMINES THE AMOUNT OF MESSAGE REACHING THE CYTOSOL
[作者:Cherry, J; Jones, H; Karschner, VA; Pekala, PH,期刊:Journal of Biological Chemistry, 页码:30812-30820 , 文章类型: Article,,卷期:2008年283-45]
- In 3T3-L1 cells, HuR is constitutively expressed and prior to induction of differentiation localized predominantly to the nucleus. Within minutes of induction of differentiation, nuclear HuR binds to its target ligand mR...
- Doc of Prophage P1 Is Inhibited by Its Antitoxin Partner Phd through Fold Complementation
[作者:Garcia-Pino, A; Christensen-Dalsgaard, M; Wyns, L; Yarmolinsky, M; Magnuson, RD; Gerdes, K; Loris, R,期刊:Journal of Biological Chemistry, 页码:30821-30827 , 文章类型: Article,,卷期:2008年283-45]
- Prokaryotic toxin-antitoxin modules are involved in major physiological events set in motion under stress conditions. The toxin Doc (death on curing) from the phd/doc module on phage P1 hosts the C-terminal domain of its...
- Osteoclast Inhibitory Lectin, an Immune Cell Product That Is Required for Normal Bone Physiology in Vivo
[作者:Kartsogiannis, V; Sims, NA; Quinn, JMW; Ly, C; Cipetic, M; Poulton, IJ; Walker, EC; Saleh, H; McGregor, NE; Wallace, ME; Smyth, MJ; Martin, TJ; Zhou, H; Ng, KW; Gillespie, MT,期刊:Journal of Biological Chemistry, 页码:30850-30860 , 文章类型: Article,,卷期:2008年283-45]
- Osteoclast inhibitory lectin (OCIL or clrb) is a member of the natural killer cell C-type lectins that have a described role mostly in autoimmune cell function. OCIL was originally identified as an osteoblast-derived inh...
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