- CHP2 Activates the Calcineurin/Nuclear Factor of Activated T Cells Signaling Pathway and Enhances the Oncogenic Potential of HEK293 Cells
[作者:Li, GD; Zhang, X; Li, R; Wang, YD; Wang, YL; Han, KJ; Qian, XP; Yang, CG; Liu, P; Wei, Q; Chen, WF; Zhang, J; Zhang, Y,期刊:Journal of Biological Chemistry, 页码:32660-32668 , 文章类型: Article,,卷期:2008年283-47]
- CHP2 (calcineurin B homologous protein 2) was initially identified as a tumor-associated antigen highly expressed in hepatocellular carcinoma. Its biological function remains largely unknown except for a potential role i...
- The Nociceptor Ion Channel TRPA1 Is Potentiated and Inactivated by Permeating Calcium Ions
[作者:Wang, YY; Chang, RB; Waters, HN; Mckemy, DD; Liman, ER,期刊:Journal of Biological Chemistry, 页码:32691-32703 , 文章类型: Article,,卷期:2008年283-47]
- The transient receptor potential A1 (TRPA1) channel is the molecular target for environmental irritants and pungent chemicals, such as cinnamaldehyde and mustard oil. Extracellular Ca2+ is a key regulator of TRPA1 activi...
- Distinct Roles of beta 1 Metal Ion-dependent Adhesion Site (MIDAS), Adjacent to MIDAS (ADMIDAS), and Ligand-associated Metal-binding Site (LIMBS) Cation-binding Sites in Ligand Recognition by Integrin alpha 2 beta 1
[作者:Valdramidou, D; Humphries, MJ; Mould, AP,期刊:Journal of Biological Chemistry, 页码:32704-32714 , 文章类型: Article,,卷期:2008年283-47]
- Integrin-ligand interactions are regulated in a complex manner by divalent cations, and previous studies have identified ligand-competent, stimulatory, and inhibitory cation-binding sites. In collagen-binding integrins, ...
- Hepatitis B Virus-induced hFGL2 Transcription Is Dependent on c-Ets-2 and MAPK Signal Pathway
[作者:Han, MF; Yan, WM; Guo, W; Xi, D; Zhou, YY; Li, WN; Gao, S; Liu, MG; Levy, G; Luo, XP; Ning, Q,期刊:Journal of Biological Chemistry, 页码:32715-32729 , 文章类型: Article,,卷期:2008年283-47]
- Fibrinogen-like protein 2 (FGL2)/fibroleukin plays a pivotal role in the pathogenesis of experimental and human fulminant and chronic viral hepatitis. To define the transcription factor(s) and upstream signal transductio...
- The COOH-terminal Domain of the JIL-1 Histone H3S10 Kinase Interacts with Histone H3 and Is Required for Correct Targeting to Chromatin
[作者:Bao, XM; Cai, WL; Deng, H; Zhang, WG; Krencik, R; Girton, J; Johansen, J; Johansen, KM,期刊:Journal of Biological Chemistry, 页码:32741-32750 , 文章类型: Article,,卷期:2008年283-47]
- The JIL-1 histone H3S10 kinase in Drosophila localizes specifically to euchromatic interband regions of polytene chromosomes and is enriched 2-fold on the male X chromosome. JIL-1 can be divided into four main domains in...
- The Boston-type Craniosynostosis Mutation MSX2 (P148H) Results in Enhanced Susceptibility of MSX2 to Ubiquitin-dependent Degradation
[作者:Yoon, WJ; Cho, YD; Cho, KH; Woo, KM; Baek, JH; Cho, JY; Kim, GS; Ryoo, HM,期刊:Journal of Biological Chemistry, 页码:32751-32761 , 文章类型: Article,,卷期:2008年283-47]
- Boston-type craniosynostosis is caused by a single amino acid substitution, P148H, in the transcription factor MSX2. The increased binding affinity of MSX2 (P148H) to the response element has led many to hypothesize that...
- Effects of Structure of Rho GTPase-activating Protein DLC-1 on Cell Morphology and Migration
[作者:Kim, TY; Healy, KD; Der, CJ; Sciaky, N; Bang, YJ; Juliano, RL,期刊:Journal of Biological Chemistry, 页码:32762-32770 , 文章类型: Article,,卷期:2008年283-47]
- DLC-1 encodes a Rho GTPase-activating protein (RhoGAP) and negative regulator of specific Rho family proteins (RhoA-C and Cdc42). DLC-1 is a multi-domain protein, with the RhoGAP catalytic domain flanked by an amino-term...
- A delta-Catenin Signaling Pathway Leading to Dendritic Protrusions
[作者:Abu-Elneel, K; Ochiishi, T; Medina, M; Remedi, M; Gastaldi, L; Caceres, A; Kosik, KS,期刊:Journal of Biological Chemistry, 页码:32781-32791 , 文章类型: Article,,卷期:2008年283-47]
- delta-Catenin is a synaptic adherens junction protein pivotally positioned to serve as a signaling sensor and integrator. Expression of delta-catenin induces filopodia-like protrusions in neurons. Here we show that the s...
- Ubiquitination and Endocytosis of Cell Adhesion Molecule DM-GRASP Regulate Its Cell Surface Presence and Affect Its Role for Axon Navigation
[作者:Thelen, K; Georg, T; Bertuch, S; Zelina, P; Pollerberg, GE,期刊:Journal of Biological Chemistry, 页码:32792-32801 , 文章类型: Article,,卷期:2008年283-47]
- DM-GRASP, cell adhesion molecule of the immunoglobulin superfamily, has been shown to promote growth and navigation of axons. We here demonstrate that clustering of DM-GRASP in the plasma membrane induces its rapid inter...
- Follistatin-like 1, a Secreted Muscle Protein, Promotes Endothelial Cell Function and Revascularization in Ischemic Tissue through a Nitric-oxide Synthase-dependent Mechanism
[作者:Ouchi, N; Oshima, Y; Ohashi, K; Higuchi, A; Ikegami, C; Izumiya, Y; Walsh, K,期刊:Journal of Biological Chemistry, 页码:32802-32811 , 文章类型: Article,,卷期:2008年283-47]
- Myogenic Akt signaling coordinates blood vessel recruitment with normal tissue growth. Here, we investigated the role of Follistatin-like 1 (Fstl1) in the regulation of endothelial cell function and blood vessel growth i...
- Structural Analysis of a Periplasmic Binding Protein in the Tripartite ATP-independent Transporter Family Reveals a Tetrameric Assembly That May Have a Role in Ligand Transport
[作者:Cuneo, MJ; Changela, A; Miklos, AE; Beese, LS; Krueger, JK; Hellinga, HW,期刊:Journal of Biological Chemistry, 页码:32812-32820 , 文章类型: Article,,卷期:2008年283-47]
- Several bacterial solute transport mechanisms involve members of the periplasmic binding protein (PBP) superfamily that bind and deliver ligand to integral membrane transport proteins in the ATP-binding cassette, tripart...
- TRPC3 Controls Agonist-stimulated Intracellular Ca2+ Release by Mediating the Interaction between Inositol 1,4,5-Trisphosphate Receptor and RACK1
[作者:Bandyopadhyay, BC; Ong, HL; Lockwich, TP; Liu, XB; Paria, BC; Singh, BB; Ambudkar, IS,期刊:Journal of Biological Chemistry, 页码:32821-32830 , 文章类型: Article,,卷期:2008年283-47]
- Activation of TRPC3 channels is concurrent with inositol 1,4,5-trisphosphate (IP3) receptor (IP3R)-mediated intracellular Ca2+ release and associated with phosphatidylinositol 4,5-bisphosphate hydrolysis and recruitment ...
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