- Cyclooxygenase-2-derived Prostaglandin E-2 Stimulates Id-1 Transcription
[作者:Subbaramaiah, K; Benezra, R; Hudis, C; Dannenberg, AJ,期刊:Journal of Biological Chemistry, 页码:33955-33968 , 文章类型: Article,,卷期:2008年283-49]
- Cyclooxygenase-2 (COX-2) and Id-1 are overexpressed in a variety of human malignancies. Recently, each of these genes was found to play a role in mediating breast cancer metastasis to the lungs, but their potential inter...
- Retinoic Acid Leads to Cytoskeletal Rearrangement through AMPK-Rac1 and Stimulates Glucose Uptake through AMPK-p38 MAPK in Skeletal Muscle Cells
[作者:Lee, YM; Lee, JO; Jung, JH; Kim, JH; Park, SH; Park, JM; Kim, EK; Suh, PG; Kim, HS,期刊:Journal of Biological Chemistry, 页码:33969-33974 , 文章类型: Article,,卷期:2008年283-49]
- Retinoic acid (RA) is one of the major components of vitamin A. In the present study, we found that retinoic acid activated AMP-activated protein kinase (AMPK). RA induced Rac1-GTP formation and phosphorylation of its do...
- Smooth Muscle Cell Arachidonic Acid Release, Migration, and Proliferation Are Markedly Attenuated in Mice Null for Calcium-independent Phospholipase A(2)beta
[作者:Moon, SH; Jenkins, CM; Mancuso, DJ; Turk, J; Gross, RW,期刊:Journal of Biological Chemistry, 页码:33975-33987 , 文章类型: Article,,卷期:2008年283-49]
- Pharmacologic evidence suggests that the lipid products generated by one or more calcium-independent phospholipases A(2) (iPLA(2)s) participate in the regulation of vascular tone through smooth muscle cell (SMC) Ca2+ sig...
- Mammalian Phosphomannomutase PMM1 Is the Brain IMP-sensitive Glucose-1,6-bisphosphatase
[作者:Veiga-da-Cunha, M; Vleugels, W; Maliekal, P; Matthijs, G; Van Schaftingen, E,期刊:Journal of Biological Chemistry, 页码:33988-33993 , 文章类型: Article,,卷期:2008年283-49]
- Glucose 1,6-bisphosphate (Glc-1,6-P-2) concentration in brain is much higher than what is required for the functioning of phosphoglucomutase, suggesting that this compound has a role other than as a cofactor of phosphomu...
- FGD2, a CDC42-specific Exchange Factor Expressed by Antigen-presenting Cells, Localizes to Early Endosomes and Active Membrane Ruffles
[作者:Huber, C; Martensson, A; Bokoch, GM; Nemazee, D; Gavin, AL,期刊:Journal of Biological Chemistry, 页码:34002-34012 , 文章类型: Article,,卷期:2008年283-49]
- Members of the Fgd (faciogenital dysplasia) gene family encode a group of critical guanine nucleotide exchange factors (GEFs), which, by specifically activating Cdc42, control cytoskeleton-dependent membrane rearrangemen...
- Snake Phospholipase A(2) Neurotoxins Enter Neurons, Bind Specifically to Mitochondria, and Open Their Transition Pores
[作者:Rigoni, M; Paoli, M; Milanesi, E; Caccin, P; Rasola, A; Bernardi, P; Montecucco, C,期刊:Journal of Biological Chemistry, 页码:34013-34020 , 文章类型: Article,,卷期:2008年283-49]
- Snake presynaptic neurotoxins with phospholipase A(2) activity are potent inducers of paralysis through inhibition of the neuromuscular junction. These neurotoxins were recently shown to induce exocytosis of synaptic ves...
- Identifying Key Components of the PrPC-PrPSc Replicative Interface
[作者:Abalos, GC; Cruite, JT; Bellon, A; Hemmers, S; Akagi, J; Mastrianni, JA; Williamson, RA; Solforosi, L,期刊:Journal of Biological Chemistry, 页码:34021-34028 , 文章类型: Article,,卷期:2008年283-49]
- In prion disease, direct interaction between the cellular prion protein (PrPC) and its misfolded disease-associated conformer PrPSc is a crucial, although poorly understood step promoting the formation of nascent PrPSc a...
- JAK2/STAT2/STAT3 Are Required for Myogenic Differentiation
[作者:Wang, KP; Wang, CH; Xiao, F; Wang, HX; Wu, ZG,期刊:Journal of Biological Chemistry, 页码:34029-34036 , 文章类型: Article,,卷期:2008年283-49]
- Skeletal muscle satellite cell-derived myoblasts are mainly responsible for postnatal muscle growth and injury-induced regeneration. However, the cellular signaling pathways that control proliferation and differentiation...
- Albumin-conjugated C34 Peptide HIV-1 Fusion Inhibitor EQUIPOTENT TO C34 AND T-20 IN VITRO WITH SUSTAINED ACTIVITY IN SCID-HU THY/LIV MICE
[作者:Stoddart, CA; Nault, G; Galkina, SA; Thibaudeau, K; Bakis, P; Bousquet-Gagnon, N; Robitaille, M; Bellomo, M; Paradis, V; Liscourt, P; Lobach, A; Rivard, ME; Ptak, RG; Mankowski, MK; Bridon, D; Quraishi, O,期刊:Journal of Biological Chemistry, 页码:34045-34052 , 文章类型: Article,,卷期:2008年283-49]
- Entry inhibitors of human immunodeficiency virus, type 1 (HIV-1) have been the focus of much recent research. C34, a potent fusion inhibitor derived from the HR2 region of gp41, was engineered into a 1:1 human serum albu...
- Evidence for a Coiled-coil Interaction Mode of Disordered Proteins from Bacterial Type III Secretion Systems
[作者:Gazi, AD; Bastaki, M; Charova, SN; Gkougkoulia, EA; Kapellios, EA; Panopoulos, NJ; Kokkinidis, M,期刊:Journal of Biological Chemistry, 页码:34062-34068 , 文章类型: Article,,卷期:2008年283-49]
- Gene clusters encoding various type III secretion system (T3SS) injectisomes, frequently code downstream of the conserved atpase gene for small hydrophilic proteins whose amino acid sequences display a propensity for int...
- Crystal Structure of Filamentous Aggregates of Human DJ-1 Formed in an Inorganic Phosphate-dependent Manner
[作者:Cha, SS; Il Jung, H; Jeon, H; An, YJ; Kim, IK; Yun, S; Ahn, HJ; Chung, KC; Lee, SH; Suh, PG; Kang, SO,期刊:Journal of Biological Chemistry, 页码:34069-34075 , 文章类型: Article,,卷期:2008年283-49]
- Mutations in the DJ-1 gene have been implicated in the autosomal recessive early onset parkinsonism. DJ-1 is a soluble dimeric protein with critical roles in response to oxidative stress and in neuronal maintenance. Howe...
- Protein Kinase A-mediated Gating of Neuregulin-dependent ErbB2-ErbB3 Activation Underlies the Synergistic Action of cAMP on Schwann Cell Proliferation
[作者:Monje, PV; Athauda, G; Wood, PM,期刊:Journal of Biological Chemistry, 页码:34087-34100 , 文章类型: Article,,卷期:2008年283-49]
- In Schwann cells (SCs), cyclic adenosine monophosphate (cAMP) enhances the action of neuregulin, the most potent known mitogen for SCs, by synergistically increasing the activation of two crucial signaling pathways: ERK ...
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