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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共75条记录   Role of Phosphatidic Acid in the Coupling of the ERK Cascade [作者：Kraft, CA; Garrido, JL; Fluharty, E; Leiva-Vega, L; Romero, G,期刊：Journal of Biological Chemistry, 页码：36636-36645 , 文章类型： Article，,卷期：2008年283-52] The production of phosphatidic acid plays a crucial role in the activation of the ERK cascade. This role was linked to the binding of phosphatidate to a specific polybasic site within the kinase domain of Raf-1. Here we ... Catalytic Mechanism of Nitrile Hydratase Proposed by Time-resolved X-ray Crystallography Using a Novel Substrate, tert-Butylisonitrile [作者：Hashimoto, K; Suzuki, H; Taniguchi, K; Noguchi, T; Yohda, M; Odaka, M,期刊：Journal of Biological Chemistry, 页码：36617-36623 , 文章类型： Article，,卷期：2008年283-52] Nitrile hydratases (NHases) have an unusual iron or cobalt catalytic center with two oxidized cysteine ligands, cysteinesulfinic acid and cysteine-sulfenic acid, catalyzing the hydration of nitriles to amides. Recently, ... Mechanism of MutS Searching for DNA Mismatches and Signaling Repair [作者：Tessmer, I; Yang, Y; Zhai, J; Du, CW; Hsieh, P; Hingorani, MM; Erie, DA,期刊：Journal of Biological Chemistry, 页码：36646-36654 , 文章类型： Article，,卷期：2008年283-52] DNA mismatch repair is initiated by the recognition of mismatches by MutS proteins. The mechanism by which MutS searches for and recognizes mismatches and subsequently signals repair remains poorly understood. We used si... Gla-rich Protein (GRP), A New Vitamin K-dependent Protein Identified from Sturgeon Cartilage and Highly Conserved in Vertebrates [作者：Viegas, CSB; Simes, DC; Laize, V; Williamson, MK; Price, PA; Cancela, ML,期刊：Journal of Biological Chemistry, 页码：36655-36664 , 文章类型： Article，,卷期：2008年283-52] We report the isolation of a novel vitamin K-dependent protein from the calcified cartilage of Adriatic sturgeon ( Acipenser nacarii). This 10.2-kDa secreted protein contains 16 gamma-carboxyglutamic acid (Gla) residues ... DYRK3 Dual-specificity Kinase Attenuates Erythropoiesis during Anemia [作者：Bogacheva, O; Bogachev, O; Menon, M; Dev, A; Houde, E; Valoret, EI; Prosser, HM; Creasy, CL; Pickering, SJ; Grau, E; Rance, K; Livi, GP; Karur, V; Erickson-Miller, CL; Wojchowski, DM,期刊：Journal of Biological Chemistry, 页码：36665-36675 , 文章类型： Article，,卷期：2008年283-52] During anemia erythropoiesis is bolstered by several factors including KIT ligand, oncostatin-M, glucocorticoids, and erythropoietin. Less is understood concerning factors that limit this process. Experiments performed u... Cell Wall Anchor Structure of BcpA Pili in Bacillus anthracis [作者：Budzik, JM; Oh, SY; Schneewind, O,期刊：Journal of Biological Chemistry, 页码：36676-36686 , 文章类型： Article，,卷期：2008年283-52] Assembly of pili in Gram-positive bacteria and their attachment to the cell wall envelope are mediated by sortases. In Bacillus cereus and its close relative Bacillus anthracis, the major pilin protein BcpA is cleaved be... The CP2 Domain of Leucyl-tRNA Synthetase Is Crucial for Amino Acid Activation and Post-transfer Editing [作者：Zhou, XL; Zhu, B; Wang, ED,期刊：Journal of Biological Chemistry, 页码：36608-36616 , 文章类型： Article，,卷期：2008年283-52] Leucyl-tRNA synthetase (LeuRS) has an insertion domain, called connective peptide 2 (CP2), either directly preceding or following the editing domain (CP1 domain), depending on the species. The global structures of the CP... The MurC Ligase Essential for Peptidoglycan Biosynthesis Is Regulated by the Serine/Threonine Protein Kinase PknA in Corynebacterium glutamicum [作者：Fiuza, M; Canova, MJ; Patin, D; Letek, M; Zanella-Cleon, I; Becchi, M; Mateos, LM; Mengin-Lecreulx, D; Molle, V; Gil, JA,期刊：Journal of Biological Chemistry, 页码：36553-36563 , 文章类型： Article，,卷期：2008年283-52] The Mur ligases play an essential role in the biosynthesis of bacterial cell-wall peptidoglycan and thus represent attractive targets for the design of novel antibacterials. These enzymes catalyze the stepwise formation ... Siderophore-controlled Iron Assimilation in the Enterobacterium Erwinia chrysanthemi EVIDENCE FOR THE INVOLVEMENT OF BACTERIOFERRITIN AND THE Suf IRON-SULFUR CLUSTER ASSEMBLY MACHINERY [作者：Expert, D; Boughammoura, A; Franza, T,期刊：Journal of Biological Chemistry, 页码：36564-36572 , 文章类型： Article，,卷期：2008年283-52] The intracellular fate of iron acquired by bacteria during siderophore-mediated assimilation is poorly understood. We investigated this question in the pathogenic enterobacterium Erwinia chrysanthemi. This bacterium prod... Tumor-derived Variants of Epstein-Barr Virus Latent Membrane Protein 1 Induce Sustained Erk Activation and c-Fos [作者：Vaysberg, M; Hatton, O; Lambert, SL; Snow, AL; Wong, B; Krams, SM; Martinez, OM,期刊：Journal of Biological Chemistry, 页码：36573-36585 , 文章类型： Article，,卷期：2008年283-52] Latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) is a proven oncogene that is essential for transformation of human B cells by the virus. LMP1 induces constitutive activation of several signal transduction pa... Plasmin Activates Epithelial Na+ Channels by Cleaving the gamma Subunit [作者：Passero, CJ; Mueller, GM; Rondon-Berrios, H; Tofovic, SP; Hughey, RP; Kleyman, TR,期刊：Journal of Biological Chemistry, 页码：36586-36591 , 文章类型： Article，,卷期：2008年283-52] Proteolytic processing of epithelial sodium channel ( ENaC) subunits occurs as channels mature within the biosynthetic pathway. The proteolytic processing events of the alpha and gamma subunits are associated with channe... Opposite Regulation of Cholesterol Levels by the Phosphatase and Hydrolase Domains of Soluble Epoxide Hydrolase [作者：EnayetAllah, AE; Luria, A; Luo, BB; Tsai, HJ; Sura, P; Hammock, BD; Grant, DF,期刊：Journal of Biological Chemistry, 页码：36592-36598 , 文章类型： Article，,卷期：2008年283-52] Soluble epoxide hydrolase (sEH) is a bifunctional enzyme with two catalytic domains: a C-terminal epoxide hydrolase domain and an N-terminal phosphatase domain. Epidemiology and animal studies have attributed a variety o... Paracrine Regulation of the Epithelial Na+ Channel in the Mammalian Collecting Duct by Purinergic P2Y(2) Receptor Tone [作者：Pochynyuk, O; Bugaj, V; Rieg, T; Insel, PA; Mironova, E; Vallon, V; Stockand, JD,期刊：Journal of Biological Chemistry, 页码：36599-36607 , 文章类型： Article，,卷期：2008年283-52] Growing evidence implicates a key role for extracellular nucleotides in cellular regulation, including of ion channels and renal function, but the mechanisms for such actions are inadequately defined. We investigated pur... An Ion Selectivity Filter in the Extracellular Domain of Cys-loop Receptors Reveals Determinants for Ion Conductance [作者：Hansen, SB; Wang, HL; Taylor, P; Sine, SM,期刊：Journal of Biological Chemistry, 页码：36066-36070 , 文章类型： Article，,卷期：2008年283-52] Neurotransmitter binding to Cys-loop receptors promotes a prodigious transmembrane flux of several million ions/s, but to date, structural determinants of ion flux have been identified flanking the membrane-spanning regi... Glutathione Depletion and Disruption of Intracellular Ionic Homeostasis Regulate Lymphoid Cell Apoptosis [作者：Franco, R; DeHaven, WI; Sifre, MI; Bortner, CD; Cidlowski, JA,期刊：Journal of Biological Chemistry, 页码：36071-36087 , 文章类型： Article，,卷期：2008年283-52] Intracellular glutathione (GSH) depletion is an important hallmark of apoptosis. We have recently shown that GSH depletion by its extrusion regulates apoptosis independently of excessive reactive oxygen species accumulat... In Skeletal Muscle Advanced Glycation End Products (AGEs) Inhibit Insulin Action and Induce the Formation of Multimolecular Complexes Including the Receptor for AGEs [作者：Cassese, A; Esposito, I; Fiory, F; Barbagallo, APM; Paturzo, F; Mirra, P; Ulianich, L; Giacco, F; Iadicicco, C; Lombardi, A; Oriente, F; Van Obberghen, E; Beguinot, F; Formisano, P; Miele, C,期刊：Journal of Biological Chemistry, 页码：36088-36099 , 文章类型： Article，,卷期：2008年283-52] Chronic hyperglycemia promotes insulin resistance at least in part by increasing the formation of advanced glycation end products (AGEs). We have previously shown that in L6 myotubes human glycated albumin (HGA) induces ...