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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共21条记录   Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions [作者：SANCHEZ TINO WILSON; DEBNATH BIKASH; CHRIST FRAUKE; OTAKE HIROYUKI; DEBYSER ZEGER; NEAMATI NOURI,期刊：Bioorganic & Medicinal Chemistry, 页码：957-963 , 文章类型： Article，,卷期：2013年21-4] Human lens epithelium-derived growth factor (LEDGF)/p75 plays an important role in the HIV life cycle by stimulating integrase (IN)-led viral DNA integration into cellular chromosomes. Mechanistic studies show the majori... Photoprotective activity of resveratrol analogues [作者：POLONINI HUDSON CAETANO; LIMA LARISSA LAVORATO; GONCALVES KARLA MARA; RESENDE DO CARMO ANTONIO MARCIO; DA SILVA ADILSON DAVID; BARBOSA RAPOSO NADIA REZENDE,期刊：Bioorganic & Medicinal Chemistry, 页码：964-968 , 文章类型： Article，,卷期：2013年21-4] Resveratrol is a promising agent for protecting human skin from UV radiation and to reduce the occurrence of cutaneous malignancies. We describe the photoprotective activity of six resveratrol analogues using the diffuse... Effects of cytoprotective antioxidants on lymphocytes from representative mitochondrial neurodegenerative diseases [作者：GOLDSCHMIDT RUTH; ARCE PABLO M; KHDOUR OMAR M; COLLIN VALERIE C; DEY SRILOY; JARUVANGSANTI JENNIFER; FASH DAVID M; HECHT SIDNEY M,期刊：Bioorganic & Medicinal Chemistry, 页码：969-978 , 文章类型： Article，,卷期：2013年21-4] Two new aza analogues of the neuroprotective agent idebenone have been synthesized and characterized. Their antioxidant activity, and ability to augment ATP levels have been evaluated in several different cell lines havi... Discovery of INT131: A selective PPAR gamma modulator that enhances insulin sensitivity [作者：TAYGERLY JOSHUA P; MCGEE LAWRENCE R; RUBENSTEIN STEVEN M; HOUZE JONATHAN B; CUSHING TIMOTHY D; LI YANG; MOTANI ALYKHAN; CHEN JINLONG; FRANKMOELLE WALTER; YE GUOSEN; LEARNED MARC R; JAEN JUAN; MIAO SHICHANG; TIMMERMANS PIETER B; THOOLEN MARTIN; KEARNEY PATRICK; FLYGARE JOHN; BECKMANN HOLGER; WEISZMANN JENNIFER; LINDSTROM MICHELLE; WALKER NIGEL; LIU JINSONG; BIERMANN DONNA; WANG ZHULUN; HAGIWARA ATSUSHI; IIDA TETSUYA; ARAMAKI HISATERU; KITAO YUKI; SHINKAI HISASHI; FURUKAWA NOBORU; NISHIU JUN; NAKAMURA MOTONAO,期刊：Bioorganic & Medicinal Chemistry, 页码：979-992 , 文章类型： Article，,卷期：2013年21-4] PPAR gamma is a member of the nuclear hormone receptor family and plays a key role in the regulation of glucose homeostasis. This Letter describes the discovery of a novel chemical class of diarylsulfonamide partial agon... Structure-activity relationship of benzodiazepine derivatives as LXXLL peptide mimetics that inhibit the interaction of vitamin D receptor with coactivators [作者：MITA YUSUKE; DODO KOSUKE; NOGUCHIYACHIDE TOMOMI; HASHIMOTO YUICHI; ISHIKAWA MINORU,期刊：Bioorganic & Medicinal Chemistry, 页码：993-1005 , 文章类型： Article，,卷期：2013年21-4] Suppression of vitamin D receptor (VDR)-mediated transcription is expected to be of therapeutic value in Paget's disease of bone. It is known that interaction between VDR and coactivators is necessary for VDR transactiva...