- Design, synthesis and characterization of novel 1,2-benzisothiazol-3(2H)-one and 1,3,4-oxadiazole hybrid derivatives: Potent inhibitors of Dengue and West Nile virus NS2B/NS3 proteases
[作者:LAI HUIGUO; DOU DENGFENG; ARAVAPALLI SRIDHAR; TERAMOTO TADAHISA; LUSHINGTON GERALD H; MWANIA TOM M; ALLISTON KEVIN R; EICHHORN DAVID M; PADMANABHAN RADHAKRISHNAN; GROUTAS WILLIAM C,期刊:Bioorganic & Medicinal Chemistry, 页码:102-113 , 文章类型: Article,,卷期:2013年21-1]
- 1,2-Benzisothiazol-3(2H)-ones and 1,3,4-oxadiazoles individually have recently attracted considerable interest in drug discovery, including as antibacterial and antifungal agents. In this study, a series of functionalize...
- 3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-x(L) and Mcl-1
[作者:SONG TING; LI XIANGQIAN; CHANG XILONG; LIANG XIAOMENG; ZHAO YAN; WU GUIYE; XIE SHENGHUI; SU PENGCHEN; WU ZHIYONG; FENG YINGANG; ZHANG ZHICHAO,期刊:Bioorganic & Medicinal Chemistry, 页码:11-20 , 文章类型: Article,,卷期:2013年21-1]
- Based on the binding mode of our previously discovered dual inhibitor of Bcl-2 and Mcl-1, 3-thiomorpholin-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile (3, S1), a library of 9-substituted 3 derivatives was synthesized...
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