- Design, Synthesis, and Preclinical Evaluations of Novel 4-Substituted 1,5-Diarylanilines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Drug Candidates
[作者:SUN LIANQI; ZHU LEI; QIAN KEDUO; QIN BINGJIE; HUANG LI; CHEN CHIN HO; LEE KUOHSIUNG; XIE LAN,期刊:Journal of Medicinal Chemistry, 页码:7219-7229 , 文章类型: Article,,卷期:2012年55-16]
- Twenty-one new 4-substituted diarylaniline compounds (DAANs) (series 13, 14, and 15) were designed, synthesized, and evaluated against wildtype and drug resistant HIV-1 viral strains. As a result, approximately a dozen n...
- Synthesis and Structure-Activity Relationships of Lapacho Analogues. 1. Suppression of Human Keratinocyte Hyperproliferation by 2-Substituted Naphtho[2,3-b]furan-4,9-diones, Activation by Enzymatic One- and Two-Electron Reduction, and Intracellular Generation of Superoxide
[作者:REICHSTEIN ALEXANDRA; VORTHERMS SILKE; BANNWITZ SVEN; TENTROP JAN; PRINZ HELGE; MUELLER KLAUS,期刊:Journal of Medicinal Chemistry, 页码:7273-7284 , 文章类型: Article,,卷期:2012年55-16]
- A series of linearly anellated lapacho quinone analogues substituted at the 2-position of the tricyclic naphtho-[2,3-b]furan-4,9-dione system were synthesized and evaluated for their ability to suppress keratinocyte hype...
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