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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共20条记录   3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa Virulence Factor LasB [作者：GARNER AMANDA L; STRUSS ANJALI K; FULLAGAR JESSICA L; AGRAWAL ARPITA; MORENO AMIRA Y; COHEN SETH M; JANDA KIM D,期刊：ACS Medicinal Chemistry Letters, 页码：668-672 , 文章类型： Article，,卷期：2012年3-8] Bacterial resistance coupled to our current arsenal of antibiotics presents us with a growing threat to public health, thus warranting the exploration of alternative antibacterial strategies. In particular, the targeting... Creation of Readily Accessible and Orally Active Analogue of Cortistatin A [作者：KOTOKU NAOYUKI; SUMII YUJI; HAYASHI TAKESHI; TAMURA SATORU; KAWACHI TAKASHI; SHIOMURA SHO; ARAI MASAYOSHI; KOBAYASHI MOTOMASA,期刊：ACS Medicinal Chemistry Letters, 页码：673-677 , 文章类型： Article，,卷期：2012年3-8] Syntheses of structurally simplified analogues of cortistatin A (1), a novel antiangiogenic steroidal alkaloid from Indonesian marine sponge, and their biological activities were investigated. The analogues were designed... Discovery of Phenylaminopyridine Derivatives as Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors [作者：KIM JUNWON; LEE DOOHYUN; PARK CHANGMIN; SO WONYOUNG; JO MINA; OK TAEDONG; KWON JEONGJIN; KONG SUNJU; JO SUYEON; KIM YOUNGMI; CHOI JIHYUN; KIM HYOUNG CHEUL; KO YOONAE; CHOI INHEE; PARK YOUNGSAM; YOON JAEWAN; JU MOON KYEONG; KIM JUNGHWAN; HAN SUNGJUN; KIM TAEHEE; CECHETTO JONATHAN; NAM JIYOUN; SOMMER PETER; LIUZZI MICHEL; LEE JINHWA; NO ZAESUNG,期刊：ACS Medicinal Chemistry Letters, 页码：678-682 , 文章类型： Article，,卷期：2012年3-8] We identified a novel class of aryl-substituted triazine compounds as potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) during a high-throughput screening campaign that evaluated more than 200000 compounds ... Lipidated Peptidomimetics with Improved Antimicrobial Activity [作者：HU YAOGANG; AMIN MOHAMAD NASSIR; PADHEE SHRUTI; WANG RONGSHENG E; QIAO QIAO; BAI GE; LI YAQONG; MATHEW ARCHANA; CAO CHUANHAI; CAI JIANFENG,期刊：ACS Medicinal Chemistry Letters, 页码：683-686 , 文章类型： Article，,卷期：2012年3-8] We report a series of lipidated alpha-AApeptides that mimic the structure and function of natural antimicrobial lipopeptides. Several short lipidated alpha-AApeptides show broad-spectrum activity against a range of clini...