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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共18条记录   Truncated Nucleosides as A(3) Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane Substitutions [作者：TOSH DILIP K; PAOLETTA SILVIA; KHAI PHAN; GAO ZHANGUO; JACOBSON KENNETH A,期刊：ACS Medicinal Chemistry Letters, 页码：596-601 , 文章类型： Article，,卷期：2012年3-7] C2-Arylethynyladenosine-5'-N-methyluronamides containing a bicyclo[3.1.0]hexane [(N)-methanocarba] ring are selective A(3) adenosine receptor (AR) agonists. Similar 4'-truncated C2-arylethynyl-(N)-methanocarba nucleoside... Discovery of CX-5461, the First Direct and Selective Inhibitor of RNA Polymerase I, for Cancer Therapeutics [作者：HADDACH MUSTAPHA; SCHWAEBE MICHAEL K; MICHAUX JEROME; NAGASAWA JOHNNY; OBRIEN SEAN E; WHITTEN JEFFREY P; PIERRE FABRICE; KERDONCUFF PAULINE; DARJANIA LEVAN; STANSFIELD RYAN; DRYGIN DENIS; ANDERES KENNA; PROFFITT CHRIS; BLIESATH JOSH; SIDDIQUIJAIN ADAM; OMORI MAY; HUSER NANNI; RICE WILLIAM G; RYCKMAN DAVID M,期刊：ACS Medicinal Chemistry Letters, 页码：602-606 , 文章类型： Article，,卷期：2012年3-7] Accelerated proliferation of solid tumor and hematologic cancer cells is linked to accelerated transcription of rDNA by the RNA polymerase I (Pol I) enzyme to produce elevated levels of rRNA (rRNA). Indeed, upregulation ...