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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共21条记录   Mutasynthesis of a Potent Anticancer Sibiromycin Analogue [作者：YONEMOTO ISAAC T; LI WEI; KHULLAR ANKUSH; REIXACH NATALIA; GERRATANA BARBARA,期刊：ACS CHEMICAL BIOLOGY, 页码：973-977 , 文章类型： Article，,卷期：2012年7-6] Pursuit of the actinomycete pyrrolobenzodiazepine natural product sibiromycin as a chemotherapeutic agent has been limited by its cardiotoxicity. Among pyrrolobenzodiazepines, cardiotoxicity is associated with hydroxylat... Enabling and Disabling Polo-like Kinase 1 Inhibition through Chemical Genetics [作者：BURKARD MARK E; SANTAMARIA ANNA; JALLEPALLI PRASAD V,期刊：ACS CHEMICAL BIOLOGY, 页码：978-981 , 文章类型： Article，,卷期：2012年7-6] Polo-like kinase 1 (Plk1) is a core regulator of cell division and an emerging target for cancer therapy. Pharmacologic inhibitors of Plk1 exist but affect other kinases, complicating their in vivo validation. To address... Selective ATP-Competitive Inhibitors of TOR Suppress Rapamycin-Insensitive Function of TORC2 in Saccharomyces cerevisiae [作者：LIU QINGSONG; REN TAO; FRESQUES TARA; OPPLIGER WOLFGANG; NILES BRAD J; HUR WOOYOUNG; SABATINI DAVID M; HALL MICHAEL N; POWERS TED; GRAY NATHANAEL S,期刊：ACS CHEMICAL BIOLOGY, 页码：982-987 , 文章类型： Article，,卷期：2012年7-6] The target of rapamycin (TOR) is a critical regulator of growth, survival, and energy metabolism. The allosteric TORC1 inhibitor rapamycin has been used extensively to elucidate the TOR related signal pathway but is limi... A Non-natural Nucleoside with Combined Therapeutic and Diagnostic Activities against Leukemia [作者：MOTEA EDWARD A; LEE IRENE; BERDIS ANTHONY J,期刊：ACS CHEMICAL BIOLOGY, 页码：988-998 , 文章类型： Article，,卷期：2012年7-6] Acute lymphoblastic leukemia (ALL) is the most common type of childhood cancer, presenting with approximately 5,000 new cases each year in the United States. An interesting enzyme implicated in this disease is terminal d... Fluorescent Probes for Imaging Endogenous beta-Actin mRNA in Living Cells Using Fluorescent Protein-Tagged Pumilio [作者：YOSHIMURA HIDEAKI; INAGUMA ASUMI; YAMADA TOSHIMICHI; OZAWA TAKEAKI,期刊：ACS CHEMICAL BIOLOGY, 页码：999-1005 , 文章类型： Article，,卷期：2012年7-6] Subcellular localization and dynamics of mRNAs control various physiological functions in living cells. A novel technique for visualizing endogenous mRNAs in living cells is necessary for investigation of the spatiotempo...