- Microfluidic technology: An economical and versatile approach for the synthesis of O-(2-[F-18]fluoroethyl)-L-tyrosine ([F-18]FET)
[作者:Bouvet, V; Wuest, M; Tam, PH; Wang, M; Wuest, F,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:2291-2295 , 文章类型: Article,,卷期:2012年22-6]
- A new synthesis of O-(2-[F-18]fluoroethyl)-L-tyrosine [F-18]FET was developed using a NanoTek (R) microfluidic synthesis system (Advion BioSciences, Inc.). Optimal reaction conditions were studied through screening diffe...
- beta-Carboline alkaloids from the leaves of Trigonostemon lii YT Chang
[作者:Li, SF; Zhang, Y; Li, Y; Li, XR; Kong, LM; Tan, CJ; Li, SL; Di, YT; He, HP; Hao, XJ,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:2296-2299 , 文章类型: Article,,卷期:2012年22-6]
- A phytochemical work on the alkaloid constituents from Trigonostemon lii Y.T. Chang was conducted to give six new beta-carboline alkaloids, trigonostemines A-F (1-6) and eight known beta-carboline alkaloids (7-14). Their...
- Synthesis and structure-activity relationship of 5-substituent-2(1H)-pyridone derivatives as anti-fibrosis agents
[作者:Chen, J; Lu, MM; Liu, B; Chen, Z; Li, QB; Tao, LJ; Hu, GY,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:2300-2302 , 文章类型: Article,,卷期:2012年22-6]
- Pyridone compounds, such as pirfenidone (PFD) and fluorofenidone (AKF-PD), are multi-target anti-fibrotic agents. Using PFD and AKF-PD as the leading compounds, two series of novel (5-substituent)-2(1H)-pyridone compound...
- Synthesis of [12]aneN(3)-dipeptide conjugates as metal-free DNA nucleases
[作者:Li, ZF; Chen, HL; Zhang, LJ; Lu, ZL,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:2303-2307 , 文章类型: Article,,卷期:2012年22-6]
- In this Letter, a series of macrocyclic polyamine [12]aneN(3)-dipeptide conjugates as a new type of metal-free nucleases were synthesized and fully characterized with H-1 NMR, C-13 NMR, IR, and HR-MS. Results indicate th...
- Substituent effects on P2-cyclopentyltetrahydrofuranyl urethanes: Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors
[作者:Ghosh, AK; Chapsal, BD; Steffey, M; Agniswamy, J; Wang, YF; Amano, M; Weber, IT; Mitsuya, H,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:2308-2311 , 文章类型: Article,,卷期:2012年22-6]
- The design, synthesis, and biological evaluation of novel C3-substituted cyclopentyltetrahydrofuranyl (Cp-THF)-derived HIV-1 protease inhibitors are described. Various C3-functional groups on the Cp-THF ligand were inves...
- Wake-promoting agents: Search for next generation modafinil: Part I
[作者:Dunn, D; Hostetler, G; Iqbal, M; Messina-McLaughlin, P; Reiboldt, A; Lin, YG; Gruner, J; Bacon, ER; Ator, MA; Chatterjee, S,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:2312-2314 , 文章类型: Article,,卷期:2012年22-6]
- In search of a next generation molecule to the novel wake promoting agent modafinil, a series of bi-phenyl derived wakefulness enhancing agents (in rat) was developed. From this work, compound 17 has been selected for ad...
- Wake-promoting agents: Search for next generation modafinil: Part II
[作者:Dunn, D; Hostetler, G; Iqbal, M; Messina-McLaughlin, P; Reiboldt, A; Lin, YG; Gruner, J; Bacon, ER; Ator, MA; Chatterjee, S,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:2315-2317 , 文章类型: Article,,卷期:2012年22-6]
- In search of a next generation molecule to modafinil, a novel wake promoting agent, we previously disclosed bi-phenyl derived racemate compound (+/-)-2 as a new generation of wake-promoting agent. Here we describe the pr...
- Tigliane diterpene esters with IFN gamma-inducing activity from the leaves of Aleurites fordii
[作者:Pei, YH; Kim, JW; Kang, HB; Lee, HK; Kim, CS; Song, HH; Chin, YW; Oh, SR,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:2318-2320 , 文章类型: Article,,卷期:2012年22-6]
- Bioactivity-guided fractionation on the leaves of Aleurites fordii led to the isolation of a new tigliane diterpene ester, 12-O-hexadecanoyl-7-oxo-5-ene-16-hydroxyphorbol-13-acetate (1) along with four known compounds, 1...
- Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors
[作者:Oza, V; Ashwell, S; Brassil, P; Breed, J; Ezhuthachan, J; Deng, C; Grondine, M; Horn, C; Liu, DF; Lyne, P; Newcombe, N; Pass, M; Read, J; Su, M; Toader, D; Yu, DW; Yu, Y; Zabludoff, S,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:2330-2337 , 文章类型: Article,,卷期:2012年22-6]
- Checkpoint kinase 1 (Chk1, CHEK1) is a Ser/Thr protein kinase that plays a key role in mediating the cellular response to DNA-damage. Synthesis and evaluation of a previously described class of Chk1 inhibitors, triazoloq...
- Structure-activity relationship of pyrrole based S-nitrosoglutathione reductase inhibitors: Carboxamide modification
[作者:Sun, XC; Qiu, J; Strong, SA; Green, LS; Wasley, JWF; Blonder, JP; Colagiovanni, DB; Stout, AM; Mutka, SC; Richards, JP; Rosenthal, GJ,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:2338-2342 , 文章类型: Article,,卷期:2012年22-6]
- The enzyme S-nitrosoglutathione reductase (GSNOR) is a member of the alcohol dehydrogenase family (ADH) that regulates the levels of S-nitrosothiols (SNOs) through catabolism of S-nitrosoglutathione (GSNO). GSNO and SNOs...
- Novel N '-benzylidene benzofuran-3-carbohydrazide derivatives as antitubercular and antifungal agents
[作者:Telvekar, VN; Belubbi, A; Bairwa, VK; Satardekar, K,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:2343-2346 , 文章类型: Article,,卷期:2012年22-6]
- Tuberculosis constitutes today a serious threat to human health worldwide, aggravated by the increasing number of identified multi-drug resistant strains of Mycobacterium tuberculosis (Mtb), its causative agent, as well ...
- Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes
[作者:Hong, SS; Lee, JH; Jeong, W; Kim, N; Jin, HZ; Hwang, BY; Lee, HJ; Lee, SJ; Jang, DS; Lee, D,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:2347-2349 , 文章类型: Article,,卷期:2012年22-6]
- A new acetylenic acid, (10E, 14Z)-9-oxooctadeca-10,14-dien-12-ynoicacid (1), was isolated from the edible mushroom Chanterelle (Cantharellus cibarius), together with a known acetylenic acid, (10E, 14Z)-9-hydroxyoctadeca-...
- Identification and evaluation of apoptotic compounds from Garcinia oligantha
[作者:Gao, XM; Yu, T; Cui, MZ; Pu, JX; Du, X; Han, QB; Hu, QF; Liu, TC; Luo, KQ; Xu, HX,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:2350-2353 , 文章类型: Article,,卷期:2012年22-6]
- Four new compounds, oliganthins A-D (1-4), and one known caged xanthone gaudichaudione H (5) were isolated from the stems of Garcinia oligantha. The structures of the new compounds were elucidated by spectroscopic eviden...
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