个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共18条记录   Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics [作者：TANG HAIFENG; WALSH SHAWN P; YAN YAN; DE JESUS REYNALDA K; SHAHRIPOUR AURASH; TEUMELSAN NARDOS; ZHU YUPING; HA SOOKHEE; OWENS KAREN A; THOMASFOWLKES BRANDE S; FELIX JOHN P; LIU JESSICA; KOHLER MARTIN; PRIEST BIRGIT T; BAILEY TIMOTHY; BROCHU RICHARD; ALONSOGALICIA MAGDALENA; KACZOROWSKI GREGORY J; ROY SOPHIE; YANG LIHU; MILLS SANDER G; GARCIA MARIA L; PASTERNAK ALEXANDER,期刊：ACS Medicinal Chemistry Letters, 页码：367-372 , 文章类型： Article，,卷期：2012年3-5] The renal outer medullary potassium channel (ROMK or K(ir)1.1) is a putative drug target for a novel class of diuretics that could be used for the treatment of hypertension and edematous states such as heart failure. An ... A Divergent SAR Study Allows Optimization of a Potent 5-HT2c Inhibitor to a Promising Antimalarial Scaffold [作者：CALDERON FELIX; VIDALMAS JAUME; BURROWS JEREMY; DE LA ROSA JUAN CARLOS; JIMENEZDIAZ MARIA BELEN; MULET TERESA; PRATS SARA; SOLANA JORGE; WITTY MICHAEL; GAMO FRANCISCO JAVIER; FERNANDEZ ESTHER,期刊：ACS Medicinal Chemistry Letters, 页码：373-377 , 文章类型： Article，,卷期：2012年3-5] From the 13 533 chemical structures published by GlaxoSmithKline in 2010, we identified 47 quality starting points for lead optimization. One of the most promising hits was the TCMDC-139046, a molecule presenting an indo...