- sigma-1 Receptor Agonist SKF10047 Inhibits Glutamate Release in Rat Cerebral Cortex Nerve Endings
[作者:Lu, CW; Lin, TY; Wang, CC; Wang, SJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:532-542 , 文章类型: Article,,卷期:2012年341-2]
- sigma-1 Receptors are expressed in the brain, and their activation has been shown to prevent neuronal death associated with glutamate toxicity. This study investigates the possible mechanism and effect of [2S-(2 alpha,6 ...
- Comparison of Delta FosB Immunoreactivity Induced by Vagal Nerve Stimulation with That Caused by Pharmacologically Diverse Antidepressants
[作者:Furmaga, H; Sadhu, M; Frazer, A,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:317-325 , 文章类型: Article,,卷期:2012年341-2]
- Vagal nerve stimulation (VNS) has been approved for treatment of refractory depression. However, there have been few, if any, studies directly comparing the effects produced by VNS in animals with those caused by antidep...
- Transmembrane Potential Polarization, Calcium Influx, and Receptor Conformational State Modulate the Sensitivity of the Imidacloprid-Insensitive Neuronal Insect Nicotinic Acetylcholine Receptor to Neonicotinoid Insecticides
[作者:Bodereau-Dubois, B; List, O; Calas-List, D; Marques, O; Communal, PY; Thany, SH; Lapied, B,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:326-339 , 文章类型: Article,,卷期:2012年341-2]
- Neonicotinoid insecticides act selectively on insect nicotinic acetylcholine receptors (nAChRs). Recent studies revealed that their efficiency was altered by the phosphorylation/dephosphorylation process and the intracel...
- Prevention of Trinitrobenzene Sulfonic Acid-Induced Experimental Colitis by Oral Administration of a Poly(lactic-coglycolic Acid) Microsphere Containing Prostaglandin E(2) Receptor Subtype 4 Agonist
[作者:Okamoto, T; Uemoto, S; Tabata, Y,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:340-349 , 文章类型: Article,,卷期:2012年341-2]
- Prostaglandin E(2) receptor subtype 4 (EP4) agonists are known to reduce intestinal inflammation and enhance epithelium regeneration. We explored the possibility of colonic delivery of an EP4 agonist, 2-[(4-{[2-((1R,2R,3...
- Phosphodiesterase 9A Regulates Central cGMP and Modulates Responses to Cholinergic and Monoaminergic Perturbation In Vivo
[作者:Kleiman, RJ; Chapin, DS; Christoffersen, C; Freeman, J; Fonseca, KR; Geoghegan, KF; Grimwood, S; Guanowsky, V; Hajos, M; Harms, JF; Helal, CJ; Hoffmann, WE; Kocan, GP; Majchrzak, MJ; McGinnis, D; McLean, S; Menniti, FS; Nelson, F; Roof, R; Schmidt, AW; Seymour, PA; Stephenson, DT; Tingley, FD; Vanase-Frawley, M; Verhoest, PR; Schmidt, CJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:396-409 , 文章类型: Article,,卷期:2012年341-2]
- Cyclic nucleotides are critical regulators of synaptic plasticity and participate in requisite signaling cascades implicated across multiple neurotransmitter systems. Phosphodiesterase 9A (PDE9A) is a high-affinity, cGMP...
- Targeting Signal Transducer and Activator of Transcription 3 Pathway by Cucurbitacin I Diminishes Self-Renewing and Radiochemoresistant Abilities in Thyroid Cancer-Derived CD133(+) Cells
[作者:Tseng, LM; Huang, PI; Chen, YR; Chen, YC; Chou, YC; Chen, YW; Chang, YL; Hsu, HS; Lan, YT; Chen, KH; Chi, CW; Chiou, SH; Yang, DM; Lee, CH,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:410-423 , 文章类型: Article,,卷期:2012年341-2]
- Anaplastic thyroid cancer (ATC) is a lethal solid tumor with poor prognosis because of its invasiveness and its resistance to current therapies. Recently, ATC-CD133(+) cells were found to have cancer stem cell (CSC) prop...
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