- Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response
[作者:Lee, KG; Xu, SL; Kang, ZH; Huo, JX; Huang, M; Liu, DX; Takeuchi, O; Akira, S; Lam, KP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5791-5796 , 文章类型: Article,,卷期:2012年109-15]
- Toll-like receptor 3 (TLR3) mediates antiviral response by recognizing double-stranded RNA. Its cytoplasmic domain is tyrosine phosphorylated upon ligand binding and initiates downstream signaling via the adapter TIR-con...
- Globally diverse Toxoplasma gondii isolates comprise six major clades originating from a small number of distinct ancestral lineages
[作者:Su, CL; Khan, A; Zhou, P; Majumdar, D; Ajzenberg, D; Darde, ML; Zhu, XQ; Ajioka, JW; Rosenthal, BM; Dubey, JP; Sibley, LD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5844-5849 , 文章类型: Article,,卷期:2012年109-15]
- Marked phenotypic variation characterizes isolates of Toxoplasma gondii, a ubiquitous zoonotic parasite that serves as an important experimental model for studying apicomplexan parasites. Progress in identifying the heri...
- Long-range mechanical force enables self-assembly of epithelial tubular patterns
[作者:Guo, CL; Ouyang, MX; Yu, JY; Maslov, J; Price, A; Shen, CY,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5576-5582 , 文章类型: Article,,卷期:2012年109-15]
- Enabling long-range transport of molecules, tubules are critical for human body homeostasis. One fundamental question in tubule formation is how individual cells coordinate their positioning over long spatial scales, whi...
- PIM1 gene cooperates with human BCL6 gene to promote the development of lymphomas
[作者:Baron, BW; Anastasi, J; Hyjek, EM; Bies, J; Reddy, PL; Dong, JF; Joseph, L; Thirman, MJ; Wroblewski, K; Wolff, L; Baron, JM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5735-5739 , 文章类型: Article,,卷期:2012年109-15]
- Diffuse large B-cell lymphomas in humans are associated with chromosomal rearrangements (similar to 40%) and/or mutations disrupting autoregulation (similar to 16%) involving the BCL6 gene. Studies of lymphoma developmen...
- Single-molecule observation of helix staggering, sliding, and coiled coil misfolding
[作者:Xi, ZQ; Gao, Y; Sirinakis, G; Guo, HL; Zhang, YL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5711-5716 , 文章类型: Article,,卷期:2012年109-15]
- The biological functions of coiled coils generally depend on efficient folding and perfect pairing of their alpha-helices. Dynamic changes in the helical registry that lead to staggered helices have only been proposed fo...
- Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin
[作者:Ambort, D; Johansson, MEV; Gustafsson, JK; Nilsson, HE; Ermund, A; Johansson, BR; Koeck, PJB; Hebert, H; Hansson, GC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5645-5650 , 文章类型: Article,,卷期:2012年109-15]
- MUC2, the major colonic mucin, forms large polymers by N-terminal trimerization and C-terminal dimerization. Although the assembly process for MUC2 is established, it is not known how MUC2 is packed in the regulated secr...
- Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in vivo
[作者:Gaiser, MR; Lammermann, T; Feng, X; Igyarto, BZ; Kaplan, DH; Tessarollo, L; Germain, RN; Udey, MC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E889-E897 , 文章类型: Article,,卷期:2012年109-15]
- After activation, Langerhans cells (LC), a distinct subpopulation of epidermis-resident dendritic cells, migrate from skin to lymph nodes where they regulate the magnitude and quality of immune responses initiated by epi...
- Loss of DNA methylation affects the recombination landscape in Arabidopsis
[作者:Mirouze, M; Lieberman-Lazarovich, M; Aversano, R; Bucher, E; Nicolet, J; Reinders, J; Paszkowski, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5880-5885 , 文章类型: Article,,卷期:2012年109-15]
- During sexual reproduction, one-half of the geneticmaterial is deposited in gametes, and a complete set of chromosomes is restored upon fertilization. Reduction of the genetic information before gametogenesis occurs in m...
- Poly(A) binding protein abundance regulates eukaryotic translation initiation factor 4F assembly in human cytomegalovirus-infected cells
[作者:McKinney, C; Perez, C; Mohr, I,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5627-5632 , 文章类型: Article,,卷期:2012年109-15]
- By commandeering cellular translation initiation factors, or destroying those dispensable for viral mRNA translation, viruses often suppress host protein synthesis. In contrast, cellular protein synthesis proceeds in hum...
- Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop
[作者:Eicher, T; Cha, HJ; Seeger, MA; Brandstatter, L; El-Delik, J; Bohnert, JA; Kern, WV; Verrey, F; Grutter, MG; Diederichs, K; Pos, KM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5687-5692 , 文章类型: Article,,卷期:2012年109-15]
- AcrAB-TolC is the major efflux protein complex in Escherichia coli extruding a vast variety of antimicrobial agents from the cell. The inner membrane component AcrB is a homotrimer, and it has been postulated that the mo...
- Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis
[作者:Boucher, D; Blais, V; Denault, JB,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5669-5674 , 文章类型: Article,,卷期:2012年109-15]
- During apoptosis, hundreds of proteins are cleaved by caspases, most of them by the executioner caspase-3. However, caspase-7, which shares the same substrate primary sequence preference as caspase-3, is better at cleavi...
- Drosophila Mgr, a Prefoldin subunit cooperating with von Hippel Lindau to regulate tubulin stability
[作者:Delgehyr, N; Wieland, U; Rangone, H; Pinson, X; Mao, GJ; Dzhindzhev, NS; McLean, D; Riparbelli, MG; Llamazares, S; Callaini, G; Gonzalez, C; Glover, DM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5729-5734 , 文章类型: Article,,卷期:2012年109-15]
- Mutations in Drosophila merry-go-round (mgr) have been known for over two decades to lead to circular mitotic figures and loss of meiotic spindle integrity. However, the identity of its gene product has remained undiscov...
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