- Localization of a toxic form of superoxide dismutase 1 protein to pathologically affected tissues in familial ALS
[作者:Brotherton, TE; Li, YJ; Cooper, D; Gearing, M; Julien, JP; Rothstein, JD; Boylan, K; Glass, JD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5505-5510 , 文章类型: Article,,卷期:2012年109-14]
- Mutations in the gene encoding superoxide dismutase 1 (SOD1) account for about 20% of the cases of familial amyotrophic lateral sclerosis (fALS). It is not known how the mutant protein causes disease, or why only a subse...
- Phosphorus-31 MRI of hard and soft solids using quadratic echo line-narrowing
[作者:Frey, MA; Michaud, M; VanHouten, JN; Insogna, KL; Madri, JA; Barrett, SE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5190-5195 , 文章类型: Article,,卷期:2012年109-14]
- Magnetic resonance imaging (MRI) of solids is rarely attempted. One of the main reasons is that the broader MR linewidths, compared to the narrow resonance of the hydrogen (H-1) in free water, limit both the attainable s...
- Brain structure in healthy adults is related to serum transferrin and the H63D polymorphism in the HFE gene
[作者:Jahanshad, N; Kohannim, O; Hibar, DP; Stein, JL; McMahon, KL; de Zubicaray, GI; Medland, SE; Montgomery, GW; Whitfield, JB; Martin, NG; Wright, MJ; Toga, AW; Thompson, PM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E851-E859 , 文章类型: Article,,卷期:2012年109-14]
- Control of iron homeostasis is essential for healthy central nervous system function: iron deficiency is associated with cognitive impairment, yet iron overload is thought to promote neurodegenerative diseases. Specific ...
- Dissecting the substrate recognition of 3-O-sulfotransferase for the biosynthesis of anticoagulant heparin
[作者:Moon, AF; Xu, YM; Woody, SM; Krahn, JM; Linhardt, RJ; Liu, J; Pedersen, LC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5265-5270 , 文章类型: Article,,卷期:2012年109-14]
- Heparin is a polysaccharide-based natural product that is used clinically as an anticoagulant drug. Heparan sulfate 3-O-sulfotransferase (3-OST) is an enzyme that transfers a sulfo group to the 3-OH position of a glucosa...
- Distinct B-cell lineage commitment distinguishes adult bone marrow hematopoietic stem cells
[作者:Ghosn, EEB; Yamamoto, R; Hamanaka, S; Yang, Y; Herzenberg, LA; Nakauchi, H; Herzenberg, LA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5394-5398 , 文章类型: Article,,卷期:2012年109-14]
- The question of whether a single hematopoietic stem cell (HSC) gives rise to all of the B-cell subsets [B-1a, B-1b, B-2, and marginal zone (MZ) B cells] in the mouse has been discussed for many years without resolution. ...
- Mesoamerican origin of the common bean (Phaseolus vulgaris L.) is revealed by sequence data
[作者:Bitocchi, E; Nanni, L; Bellucci, E; Rossi, M; Giardini, A; Zeuli, PS; Logozzo, G; Stougaard, J; McClean, P; Attene, G; Papa, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E788-E796 , 文章类型: Article,,卷期:2012年109-14]
- Knowledge about the origins and evolution of crop species represents an important prerequisite for efficient conservation and use of existing plant materials. This study was designed to solve the ongoing debate on the or...
- Distributed representation of chemical features and tunotopic organization of glomeruli in the mouse olfactory bulb
[作者:Ma, LM; Qiu, Q; Gradwohl, S; Scott, A; Yu, EQ; Alexander, R; Wiegraebe, W; Yu, CR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5481-5486 , 文章类型: Article,,卷期:2012年109-14]
- In the mammalian brain, similar features of the sensory stimuli are often represented in proximity in the sensory areas. However, how chemical features are represented in the olfactory bulb has been controversial. Questi...
- Plasmodium falciparum merozoite surface protein 1 blocks the proinflammatory protein S100P
[作者:Waisberg, M; Cerqueira, GC; Yager, SB; Francischetti, IMB; Lu, JH; Gera, N; Srinivasan, P; Miura, K; Rada, B; Lukszo, J; Barbian, KD; Leto, TL; Porcella, SF; Narum, DL; El-Sayed, N; Miller, LH; Pierce, SK,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5429-5434 , 文章类型: Article,,卷期:2012年109-14]
- The malaria parasite, Plasmodium falciparum, and the human immune system have coevolved to ensure that the parasite is not eliminated and reinfection is not resisted. This relationship is likely mediated through a myriad...
- Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity
[作者:Maurer, T; Garrenton, LS; Oha, A; Pitts, K; Anderson, DJ; Skelton, NJ; Fauber, BP; Pan, B; Malek, S; Stokoe, D; Ludlam, MJC; Bowman, KK; Wu, JS; Giannetti, AM; Starovasnik, MA; Mellman, I; Jackson, PK; Rudolph, J; Wang, WR; Fang, G,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5299-5304 , 文章类型: Article,,卷期:2012年109-14]
- The Ras gene is frequently mutated in cancer, and mutant Ras drives tumorigenesis. Although Ras is a central oncogene, small molecules that bind to Ras in a well-defined manner and exert inhibitory effects have not been ...
- Soluble factors from T cells inhibiting X4 strains of HIV are a mixture of beta chemokines and RNases
[作者:Cocchi, F; DeVico, AL; Lu, WY; Popovic, M; Latinovic, O; Sajadi, MM; Redfield, RR; Lafferty, MK; Galli, M; Garzino-Demo, A; Gallo, RC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5411-5416 , 文章类型: Article,,卷期:2012年109-14]
- T-cell-derived soluble factors that inhibit both X4 and R5 HIV are recognized as important in controlling HIV. Whereas three beta chemokines, regulated-on-activation normal T-cell expressed and secreted (RANTES), macroph...
- Carotenoid oxidation products are stress signals that mediate gene responses to singlet oxygen in plants
[作者:Ramel, F; Birtic, S; Ginies, C; Soubigou-Taconnat, L; Triantaphylides, C; Havaux, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5535-5540 , 文章类型: Article,,卷期:2012年109-14]
- O-1(2) (singlet oxygen) is a reactive O-2 species produced from triplet excited chlorophylls in the chloroplasts, especially when plants are exposed to excess light energy. Similarly to other active O-2 species, O-1(2) h...
- Cells test substrate rigidity by local contractions on submicrometer pillars
[作者:Ghassemi, S; Meacci, G; Liu, SM; Gondarenko, AA; Mathur, A; Roca-Cusachs, P; Sheetz, MP; Hone, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5328-5333 , 文章类型: Article,,卷期:2012年109-14]
- Cell growth and differentiation are critically dependent upon matrix rigidity, yet many aspects of the cellular rigidity-sensing mechanism are not understood. Here, we analyze matrix forces after initial cell-matrix cont...
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