- Single amino acid radiocarbon dating of Upper Paleolithic modern humans
[作者:Marom, A; McCullagh, JSO; Higham, TFG; Sinitsyn, AA; Hedges, REM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6878-6881 , 文章类型: Article,,卷期:2012年109-18]
- Archaeological bones are usually dated by radiocarbon measurement of extracted collagen. However, low collagen content, contamination from the burial environment, or museum conservation work, such as addition of glues, p...
- Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apc(min) mice by inhibiting IL-10 secretion and regulatory T-cell generation
[作者:Serebrennikova, OB; Tsatsanis, C; Mao, CC; Gounaris, E; Ren, WY; Siracusa, LD; Eliopoulos, AG; Khazaie, K; Tsichlis, PN,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E1082-E1091 , 文章类型: Article,,卷期:2012年109-18]
- To address the role of Tpl2, a MAP3K8 that regulates innate/adaptive immunity and inflammation, in intestinal tumorigenesis, we crossed a Tpl2 KO allele into the Apc(min/+) genetic background. Here, we show that Apc(min/...
- BRD4 is an atypical kinase that phosphorylates Serine2 of the RNA Polymerase II carboxy-terminal domain
[作者:Devaiah, BN; Lewis, BA; Cherman, N; Hewitt, MC; Albrecht, BK; Robey, PG; Ozato, K; Sims, RJ; Singer, DS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6927-6932 , 文章类型: Article,,卷期:2012年109-18]
- The bromodomain protein, BRD4, has been identified recently as a therapeutic target in acute myeloid leukemia, multiple myeloma, Burkitt's lymphoma, NUT midline carcinoma, colon cancer, and inflammatory disease; its loss...
- Long-lived epithelial immunity by tissue-resident memory T (T-RM) cells in the absence of persisting local antigen presentation
[作者:Mackay, LK; Stock, AT; Ma, JZ; Jones, CM; Kent, SJ; Mueller, SN; Heath, WR; Carbone, FR; Gebhardt, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7037-7042 , 文章类型: Article,,卷期:2012年109-18]
- Although circulating memory T cells provide enhanced protection against pathogen challenge, they often fail to do so if infection is localized to peripheral or extralymphoid compartments. In those cases, it is T cells al...
- Lysocardiolipin acyltransferase 1 (ALCAT1) controls mitochondrial DNA fidelity and biogenesis through modulation of MFN2 expression
[作者:Li, J; Liu, XL; Wang, HY; Zhang, WP; Chan, DC; Shi, YG,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6975-6980 , 文章类型: Article,,卷期:2012年109-18]
- Oxidative stress causes mitochondrial fragmentation and dysfunction in age-related diseases through unknown mechanisms. Cardiolipin (CL) is a phospholipid required for mitochondrial oxidative phosphorylation. The functio...
- MHC class I antigen processing distinguishes endogenous antigens based on their translation from cellular vs. viral mRNA
[作者:Dolan, BP; Sharma, AA; Gibbs, JS; Cunningham, TJ; Bennink, JR; Yewdell, JW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7025-7030 , 文章类型: Article,,卷期:2012年109-18]
- To better understand the generation of MHC class I-associated peptides, we used a model antigenic protein whose proteasome-mediated degradation is rapidly and reversibly controlled by Shield-1, a cell-permeant drug. When...
- Pleckstrin homology domain-interacting protein (PHIP) as a marker and mediator of melanoma metastasis
[作者:De Semir, D; Nosrati, M; Bezrookove, V; Dar, AA; Federman, S; Bienvenu, G; Venna, S; Rangel, J; Climent, J; Tamguney, TMM; Thummala, S; Tong, S; Leong, SPL; Haqq, C; Billings, P; Miller, JR; Sagebiel, RW; Debs, R; Kashani-Sabet, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7067-7072 , 文章类型: Article,,卷期:2012年109-18]
- Although melanomas with mutant v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) can now be effectively targeted, there is no molecular target for most melanomas expressing wildtype BRAF. Here, we show that the activ...
- Snapshot of virus evolution in hypersaline environments from the characterization of a membrane-containing Salisaeta icosahedral phage 1
[作者:Aalto, AP; Bitto, D; Ravantti, JJ; Bamford, DH; Huiskonen, JT; Oksanen, HM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7079-7084 , 文章类型: Article,,卷期:2012年109-18]
- The multitude of archaea and bacteria inhabiting extreme environments has only become evident during the last decades. As viruses apply a significant evolutionary force to their hosts, there is an inherent value in learn...
- Cavities determine the pressure unfolding of proteins
[作者:Roche, J; Caro, JA; Norberto, DR; Barthe, P; Roumestand, C; Schlessman, JL; Garcia, AE; Garcia-Moreno, B; Royer, CA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6945-6950 , 文章类型: Article,,卷期:2012年109-18]
- It has been known for nearly 100 years that pressure unfolds proteins, yet the physical basis of this effect is not understood. Unfolding by pressure implies that the molar volume of the unfolded state of a protein is sm...
- Heterosis of Arabidopsis hybrids between C24 and Col is associated with increased photosynthesis capacity
[作者:Fujimoto, R; Taylor, JM; Shirasawa, S; Peacock, WJ; Dennis, ES,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7109-7114 , 文章类型: Article,,卷期:2012年109-18]
- Arabidopsis thaliana shows hybrid vigor (heterosis) in progeny of crosses between Columbia-0 and C24 accessions. Hybrid vigor was evident as early as mature seeds and in seedlings 3 d after sowing (DAS). At 3 DAS, genes ...
- Predator-induced macroevolutionary trends in Mesozoic crinoids
[作者:Gorzelak, P; Salamon, MA; Baumiller, TK,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7004-7007 , 文章类型: Article,,卷期:2012年109-18]
- Sea urchins are a major component of recent marine communities where they exert a key role as grazers and benthic predators. However, their impact on past marine organisms, such as crinoids, is hard to infer in the fossi...
- Dynamic migration of gamma delta intraepithelial lymphocytes requires occludin
[作者:Edelblum, KL; Shen, L; Weber, CR; Marchiando, AM; Clay, BS; Wang, YM; Prinz, I; Malissen, B; Sperling, AI; Turner, JR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7097-7102 , 文章类型: Article,,卷期:2012年109-18]
- gamma delta intraepithelial lymphocytes (IELs) are located beneath or between adjacent intestinal epithelial cells and are thought to contribute to homeostasis and disease pathogenesis. Using in vivo microscopy to image ...
- Pressure tunes electrical resistivity by four orders of magnitude in amorphous Ge2Sb2Te5 phase-change memory alloy
[作者:Xu, M; Cheng, YQ; Wang, L; Sheng, HW; Meng, Y; Yang, WG; Han, XD; Ma, E,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E1055-E1062 , 文章类型: Article,,卷期:2012年109-18]
- Ge-Sb-Te-based phase-change memory is one of the most promising candidates to succeed the current flash memories. The application of phase-change materials for data storage and memory devices takes advantage of the fast ...
- Chronic restraint stress attenuates p53 function and promotes tumorigenesis
[作者:Feng, ZH; Liu, LX; Zhang, C; Zheng, TS; Wang, JB; Lin, MH; Zhao, YH; Wang, XW; Levine, AJ; Hu, WW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7013-7018 , 文章类型: Article,,卷期:2012年109-18]
- Epidemiological studies strongly suggest that chronic psychological stress promotes tumorigenesis. However, its direct link in vivo and the underlying mechanisms that cause this remain unclear. This study provides direct...
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