- Biotinylation of lysine method identifies acetylated histone H3 lysine 79 in Saccharomyces cerevisiae as a substrate for Sir2
[作者:Bheda, P; Swatkoski, S; Fiedler, KL; Boeke, JD; Cotter, RJ; Wolberger, C,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E916-E925 , 文章类型: Article,,卷期:2012年109-16]
- Although the biological roles of many members of the sirtuin family of lysine deacetylases have been well characterized, a broader understanding of their role in biology is limited by the challenges in identifying new su...
- Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma
[作者:Mann, KM; Ward, JM; Yew, CCK; Kovochich, A; Dawson, DW; Black, MA; Brett, BT; Sheetz, TE; Dupuy, AJ; Chang, DK; Biankin, AV; Waddell, N; Kassahn, KS; Grimmond, SM; Rust, AG; Adams, DJ; Jenkins, NA; Copeland, NG,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5934-5941 , 文章类型: Article,,卷期:2012年109-16]
- Pancreatic cancer is one of the most deadly cancers affecting the Western world. Because the disease is highly metastatic and difficult to diagnosis until late stages, the 5-y survival rate is around 5%. The identificati...
- Small molecule inhibitors of influenza A and B viruses that act by disrupting subunit interactions of the viral polymerase
[作者:Muratore, G; Goracci, L; Mercorelli, B; Foeglein, A; Digard, P; Cruciani, G; Palu, G; Loregian, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6247-6252 , 文章类型: Article,,卷期:2012年109-16]
- Influenza viruses are the cause of yearly epidemics and occasional pandemics that represent a significant challenge to public health. Current control strategies are imperfect and there is an unmet need for new antiviral ...
- Buckling-induced encapsulation of structured elastic shells under pressure
[作者:Shim, J; Perdigou, C; Chen, ER; Bertoldi, K; Reis, PM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5978-5983 , 文章类型: Article,,卷期:2012年109-16]
- We introduce a class of continuum shell structures, the Buckliball, which undergoes a structural transformation induced by buckling under pressure loading. The geometry of the Buckliball comprises a spherical shell patte...
- Grid cells in rat entorhinal cortex encode physical space with independent firing fields and phase precession at the single-trial level
[作者:Reifenstein, ET; Kempter, R; Schreiber, S; Stemmler, MB; Herz, AVM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6301-6306 , 文章类型: Article,,卷期:2012年109-16]
- When a rat moves, grid cells in its entorhinal cortex become active in multiple regions of the external world that form a hexagonal lattice. As the animal traverses one such "firing field," spikes tend to occur at succes...
- Heterochromatin protein 1 homologue Swi6 acts in concert with Ers1 to regulate RNAi-directed heterochromatin assembly
[作者:Hayashi, A; Ishida, M; Kawaguchi, R; Urano, T; Murakami, Y; Nakayama, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6159-6164 , 文章类型: Article,,卷期:2012年109-16]
- In fission yeast, the RNAi pathway is required for centromeric heterochromatin assembly. siRNAs derived from centromeric transcripts are incorporated into the RNA-induced transcriptional silencing (RITS) complex and dire...
- Predictable and tunable half-life extension of therapeutic agents by controlled chemical release from macromolecular conjugates
[作者:Santi, DV; Schneider, EL; Reid, R; Robinson, L; Ashley, GW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6211-6216 , 文章类型: Article,,卷期:2012年109-16]
- Conjugation to macromolecular carriers is a proven strategy for improving the pharmacokinetics of drugs, with many stable polyethylene glycol conjugates having reached the market. Stable conjugates suffer several limitat...
- Tumor initiating but differentiated luminal-like breast cancer cells are highly invasive in the absence of basal-like activity
[作者:Kim, J; Villadsen, R; Sorlie, T; Fogh, L; Gronlund, SZ; Fridriksdottir, AJ; Kuhn, I; Rank, F; Wielenga, VT; Solvang, H; Edwards, PAW; Borresen-Dale, AL; Ronnov-Jessen, L; Bissell, MJ; Petersen, OW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6124-6129 , 文章类型: Article,,卷期:2012年109-16]
- The majority of human breast cancers exhibit luminal epithelial differentiation. However, most aggressive behavior, including invasion and purported cancer stem cell activity, are considered characteristics of basal-like...
- Hierarchical processing of complex motion along the primate dorsal visual pathway
[作者:Mineault, PJ; Khawaja, FA; Butts, DA; Pack, CC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E972-E980 , 文章类型: Article,,卷期:2012年109-16]
- Neurons in the medial superior temporal (MST) area of the primate visual cortex respond selectively to complex motion patterns defined by expansion, rotation, and deformation. Consequently they are often hypothesized to ...
- Mismatch repair-dependent mutagenesis in nondividing cells
[作者:Rodriguez, GP; Romanova, NV; Bao, GB; Rouf, NC; Kow, YW; Crouse, GF,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6153-6158 , 文章类型: Article,,卷期:2012年109-16]
- Mismatch repair (MMR) is a major DNA repair pathway in cells from all branches of life that removes replication errors in a strand-specific manner, such that mismatched nucleotides are preferentially removed from the new...
- Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a Legionella effector functioning in membrane trafficking
[作者:Ge, JN; Gong, YN; Xu, Y; Shao, F,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6193-6198 , 文章类型: Article,,卷期:2012年109-16]
- Legionella pneumophila, the causative agent of Legionnaires' pneumonia, resides in a distinct vacuole structure called Legionella-containing vacuole (LCV). The LCV resists fusion with the lysosome and permits efficient b...
- Structural and mechanistic analysis of the membrane-embedded glycosyltransferase WaaA required for lipopolysaccharide synthesis
[作者:Schmidt, H; Hansen, G; Singh, S; Hanuszkiewicz, A; Lindner, B; Fukase, K; Woodard, RW; Holst, O; Hilgenfeld, R; Mamat, U; Mesters, JR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6253-6258 , 文章类型: Article,,卷期:2012年109-16]
- WaaA is a key enzyme in the biosynthesis of LPS, a critical component of the outer envelope of Gram-negative bacteria. Embedded in the cytoplasmic face of the inner membrane, WaaA catalyzes the transfer of 3-deoxy-D-mann...
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