- Constructing and Validating Initial C alpha Models from Subnanometer Resolution Density Maps with Pathwalking
[作者:Baker, MR; Rees, I; Ludtke, SJ; Chiu, W; Baker, ML,期刊:Structure, 页码:450-463 , 文章类型: Article,,卷期:2012年20-3]
- A significant number of macromolecular structures solved by electron cryo-microscopy and X-ray crystallography obtain resolutions of 3.5-6 angstrom, at which direct atomistic interpretation is difficult. To address this,...
- EM-Fold: De Novo Atomic-Detail Protein Structure Determination from Medium-Resolution Density Maps
[作者:Lindert, S; Alexander, N; Wotzel, N; Karakas, M; Stewart, PL; Meiler, J,期刊:Structure, 页码:464-478 , 文章类型: Article,,卷期:2012年20-3]
- Electron density maps of membrane proteins or large macromolecular complexes are frequently only determined at medium resolution between 4 angstrom and 10 angstrom, either by cryo-electron microscopy or X-ray crystallogr...
- Variable Lymphocyte Receptor Recognition of the Immunodominant Glycoprotein of Bacillus anthracis Spores
[作者:Kirchdoerfer, RN; Herrin, BR; Han, BW; Turnbough, CL; Cooper, MD; Wilson, IA,期刊:Structure, 页码:479-486 , 文章类型: Article,,卷期:2012年20-3]
- Variable lymphocyte receptors (VLRs) are the adaptive immune receptors of jawless fish, which evolved adaptive immunity independent of other vertebrates. In lieu of the immunoglobulin fold-based T and B cell receptors, l...
- Structure of the Human Obesity Receptor Leptin-Binding Domain Reveals the Mechanism of Leptin Antagonism by a Monoclonal Antibody
[作者:Carpenter, B; Hemsworth, GR; Wu, ZD; Maamra, M; Strasburger, CJ; Ross, RJ; Artymiuk, PJ,期刊:Structure, 页码:487-497 , 文章类型: Article,,卷期:2012年20-3]
- Leptin regulates energy homeostasis, fertility, and the immune system, making it an important drug target. However, due to a complete lack of structural data for the obesity receptor (ObR), leptin's mechanism of receptor...
- Capsomer Dynamics and Stabilization in the T=12 Marine Bacteriophage SIO-2 and Its Procapsid Studied by CryoEM
[作者:Lander, GC; Baudoux, AC; Azam, F; Potter, CS; Carragher, B; Johnson, JE,期刊:Structure, 页码:498-503 , 文章类型: Article,,卷期:2012年20-3]
- We report the subnanometer cryo-electron microscopy (cryoEM) reconstruction of a marine siphovirus, the Vibrio phage SIO-2. This phage is lytic for related Vibrio species with significant ecological importance, including...
|