- Altered antisense-to-sense transcript ratios in breast cancer
[作者:Maruyama, R; Shipitsin, M; Choudhury, S; Wu, ZH; Protopopov, A; Yao, J; Lo, PK; Bessarabova, M; Ishkin, A; Nikolsky, Y; Liu, XS; Sukumar, S; Polyak, K,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2820-2824 , 文章类型: Article,,卷期:2012年109-8]
- Transcriptome profiling studies suggest that a large fraction of the genome is transcribed and many transcripts function independent of their protein coding potential. The relevance of noncoding RNAs (ncRNAs) in normal p...
- Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility
[作者:Wu, Q; Whiddon, BB; Palmiter, RD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3155-3160 , 文章类型: Article,,卷期:2012年109-8]
- Leptin-deficient (Lep(ob/ob)) mice are obese, diabetic, and infertile. Ablation of neurons that make agouti-related protein (AgRP) in moderately obese adult Lep(ob/ob) mice caused severe anorexia. The mice stopped eating...
- Arabidopsis circadian clock protein, TOC1, is a DNA-binding transcription factor
[作者:Gendron, JM; Pruneda-Paz, JL; Doherty, CJ; Gross, AM; Kang, SE; Kay, SA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3167-3172 , 文章类型: Article,,卷期:2012年109-8]
- The first described feedback loop of the Arabidopsis circadian clock is based on reciprocal regulation between TIMING OF CAB EXPRESSION 1 (TOC1) and CIRCADIAN CLOCK-ASSOCIATED 1 (CCA1)/LATE ELONGATED HYPOCOTYL (LHY). CCA...
- Impact of cross-protective vaccines on epidemiological and evolutionary dynamics of influenza
[作者:Arinaminpathy, N; Ratmann, O; Koelle, K; Epstein, SL; Price, GE; Viboud, C; Miller, MA; Grenfell, BT,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3173-3177 , 文章类型: Article,,卷期:2012年109-8]
- Large-scale immunization has profoundly impacted control of many infectious diseases such as measles and smallpox because of the ability of vaccination campaigns to maintain long-term herd immunity and, hence, indirect p...
- A serpentinite-hosted ecosystem in the Southern Mariana Forearc
[作者:Ohara, Y; Reagan, MK; Fujikura, K; Watanabe, H; Michibayashi, K; Ishii, T; Stern, RJ; Pujana, I; Martinez, F; Girard, G; Ribeiro, J; Brounce, M; Komori, N; Kino, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2831-2835 , 文章类型: Article,,卷期:2012年109-8]
- Several varieties of seafloor hydrothermal vents with widely varying fluid compositions and temperatures and vent communities occur in different tectonic settings. The discovery of the Lost City hydrothermal field in the...
- Nonequilibrium atmospheric secondary organic aerosol formation and growth
[作者:Perraud, V; Bruns, EA; Ezell, MJ; Johnson, SN; Yu, Y; Alexander, ML; Zelenyuk, A; Imre, D; Chang, WL; Dabdub, D; Pankow, JF; Finlayson-Pitts, BJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2836-2841 , 文章类型: Article,,卷期:2012年109-8]
- Airborne particles play critical roles in air quality, health effects, visibility, and climate. Secondary organic aerosols (SOA) formed from oxidation of organic gases such as a-pinene account for a significant portion o...
- Significance analysis of xMap cytokine bead arrays
[作者:Won, JH; Goldberger, O; Shen-Orr, SS; Davis, MM; Olshen, RA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2848-2853 , 文章类型: Article,,卷期:2012年109-8]
- Highly multiplexed assays using antibody coated, fluorescent (xMap) beads are widely used to measure quantities of soluble analytes, such as cytokines and antibodies in clinical and other studies. Current analyses of the...
- Integrated cross-species transcriptional network analysis of metastatic susceptibility
[作者:Hu, Y; Wu, G; Rusch, M; Lukes, L; Buetow, KH; Zhang, JH; Hunter, KW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3184-3189 , 文章类型: Article,,卷期:2012年109-8]
- Metastatic disease is the proximal cause of mortality for most cancers and remains a significant problem for the clinical management of neoplastic disease. Recent advances in global transcriptional analysis have enabled ...
- Unusual macrocyclic lactone sex pheromone of Parcoblatta lata, a primary food source of the endangered red-cockaded woodpecker
[作者:Eliyahu, D; Nojima, S; Santangelo, RG; Carpenter, S; Webster, FX; Kiemle, DJ; Gemeno, C; Leal, WS; Schal, C,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E490-E496 , 文章类型: Article,,卷期:2012年109-8]
- Wood cockroaches in the genus Parcoblatta, comprising 12 species endemic to North America, are highly abundant in southeastern pine forests and represent an important prey of the endangered red-cockaded woodpecker, Picoi...
- Maternal support in early childhood predicts larger hippocampal volumes at school age
[作者:Luby, JL; Barch, DM; Belden, A; Gaffrey, MS; Tillman, R; Babb, C; Nishino, T; Suzuki, H; Botteron, KN,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2854-2859 , 文章类型: Article,,卷期:2012年109-8]
- Early maternal support has been shown to promote specific gene expression, neurogenesis, adaptive stress responses, and larger hippocampal volumes in developing animals. In humans, a relationship between psychosocial fac...
- STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability
[作者:Luo, TP; Masson, K; Jaffe, JD; Silkworth, W; Ross, NT; Scherer, CA; Scholl, C; Frohling, S; Carr, SA; Stern, AM; Schreiber, SL; Golub, TR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2860-2865 , 文章类型: Article,,卷期:2012年109-8]
- Approximately 30% of human cancers harbor oncogenic gain-of-function mutations in KRAS. Despite interest in KRAS as a therapeutic target, direct blockade of KRAS function with small molecules has yet to be demonstrated. ...
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