- Graptoloid diversity and disparity became decoupled during the Ordovician mass extinction
[作者:Bapst, DW; Bullock, PC; Melchin, MJ; Sheets, HD; Mitchell, CE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3428-3433 , 文章类型: Article,,卷期:2012年109-9]
- The morphological study of extinct taxa allows for analysis of a diverse set of macroevolutionary hypotheses, including testing for change in the magnitude of morphological divergence, extinction selectivity on form, and...
- Ancient climate change, antifreeze, and the evolutionary diversification of Antarctic fishes
[作者:Near, TJ; Dornburg, A; Kuhn, KL; Eastman, JT; Pennington, JN; Patarnello, T; Zane, L; Fernandez, DA; Jones, CD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3434-3439 , 文章类型: Article,,卷期:2012年109-9]
- The Southern Ocean around Antarctica is among the most rapidly warming regions on Earth, but has experienced episodic climate change during the past 40 million years. It remains unclear how ancient periods of climate cha...
- Transgene-mediated cosuppression and RNA interference enhance germ-line apoptosis in Caenorhabditis elegans
[作者:Adamo, A; Woglar, A; Silva, N; Penkner, A; Jantsch, V; La Volpe, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3440-3445 , 文章类型: Article,,卷期:2012年109-9]
- Introduction of multiple copies of a germ-line-expressed gene elicits silencing of the corresponding endogenous gene during Caenorhabditis elegans oogenesis; this process is referred to as germ-line cosuppression. Transf...
- Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice
[作者:Yasuda, K; Muto, T; Kawagoe, T; Matsumoto, M; Sasaki, Y; Matsushita, K; Taki, Y; Futatsugi-Yumikura, S; Tsutsui, H; Ishii, KJ; Yoshimoto, T; Akira, S; Nakanishi, K,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3451-3456 , 文章类型: Article,,卷期:2012年109-9]
- When animals are infected with helminthic parasites, resistant hosts show type II helper T immune responses to expel worms. Recently, natural helper (NH) cells or nuocytes, newly identified type II innate lymphoid cells,...
- Inhibitor of streptokinase gene expression improves survival after group A streptococcus infection in mice
[作者:Sun, HM; Xu, YX; Sitkiewicz, I; Ma, YB; Wang, XX; Yestrepsky, BD; Huang, YP; Lapadatescu, MC; Larsen, MJ; Larsen, SD; Musser, JM; Ginsburg, D,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3469-3474 , 文章类型: Article,,卷期:2012年109-9]
- The widespread occurrence of antibiotic resistance among human pathogens is a major public health problem. Conventional antibiotics typically target bacterial killing or growth inhibition, resulting in strong selection f...
- Insulin-like growth factor-binding protein 2-driven glioma progression is prevented by blocking a clinically significant integrin, integrin-linked kinase, and NF-kappa B network
[作者:Holmes, KM; Annala, M; Chua, CYX; Dunlap, SM; Liu, YX; Hugen, N; Moore, LM; Cogdell, D; Hu, LM; Nykter, M; Hess, K; Fuller, GN; Zhang, W,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3475-3480 , 文章类型: Article,,卷期:2012年109-9]
- Insulin-like growth factor-binding protein 2 (IGFBP2) is increasingly recognized as a glioma oncogene, emerging as a target for therapeutic intervention. In this study, we used an integrative approach to characterizing t...
- Crucial role of copper in detection of metal-coordinating odorants
[作者:Duan, XF; Block, E; Li, Z; Connelly, T; Zhang, J; Huang, ZM; Su, XB; Pan, Y; Wu, LF; Chi, QY; Thomas, S; Zhang, SZ; Ma, MH; Matsunami, H; Chen, GQ; Zhuang, HY,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3492-3497 , 文章类型: Article,,卷期:2012年109-9]
- Odorant receptors (ORs) in olfactory sensory neurons (OSNs) mediate detection of volatile odorants. Divalent sulfur compounds, such as thiols and thioethers, are extremely potent odorants. We identify a mouse OR, MOR244-...
- Spontaneous generation of rapidly transmissible prions in transgenic mice expressing wild-type bank vole prion protein
[作者:Watts, JC; Giles, K; Stohr, J; Oehler, A; Bhardwaj, S; Grillo, SK; Patel, S; DeArmond, SJ; Prusiner, SB,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3498-3503 , 文章类型: Article,,卷期:2012年109-9]
- Currently, there are no animal models of the most common human prion disorder, sporadic Creutzfeldt-Jakob disease (CJD), in which prions are formed spontaneously from wild-type (WT) prion protein (PrP). Interestingly, ba...
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