- Identification of a cis-acting element that localizes mRNA to synapses
[作者:Meer, EJ; Wang, DO; Kim, S; Barr, I; Guo, F; Martin, KC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4639-4644 , 文章类型: Article,,卷期:2012年109-12]
- Messenger RNA (mRNA) localization and regulated translation can spatially restrict gene expression to each of the thousands of synaptic compartments formed by a single neuron. Although cis-acting RNA elements have been s...
- Injury-independent induction of reactive gliosis in retina by loss of function of the LIM homeodomain transcription factor Lhx2
[作者:de Melo, J; Miki, K; Rattner, A; Smallwood, P; Zibetti, C; Hirokawa, K; Monuki, ES; Campochiaro, PA; Blackshaw, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4657-4662 , 文章类型: Article,,卷期:2012年109-12]
- Muller glia are the primary glial subtype in the retina and perform a wide range of physiological tasks in support of retinal function, but little is known about the transcriptional network that maintains these cells in ...
- Agonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel
[作者:Roberts, JA; Allsopp, RC; El Ajouz, S; Vial, C; Schmid, R; Young, MT; Evans, RJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4663-4667 , 文章类型: Article,,卷期:2012年109-12]
- P2X receptors for ATP have a wide range of physiological roles and comprise a structurally distinct family of ligand-gated trimeric ion channels. The crystal structure of a P2X4 receptor, in combination with mutagenesis ...
- Root gravitropism is regulated by a transient lateral auxin gradient controlled by a tipping-point mechanism
[作者:Band, LR; Wells, DM; Larrieu, A; Sun, JY; Middleton, AM; French, AP; Brunoud, G; Sato, EM; Wilson, MH; Peret, B; Oliva, M; Swarup, R; Sairanen, I; Parry, G; Ljung, K; Beeckman, T; Garibaldi, JM; Estelle, M; Owen, MR; Vissenberg, K; Hodgman, TC; Pridmore, TP; King, JR; Vernoux, T; Bennett, MJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4668-4673 , 文章类型: Article,,卷期:2012年109-12]
- Gravity profoundly influences plant growth and development. Plants respond to changes in orientation by using gravitropic responses to modify their growth. Cholodny and Went hypothesized over 80 years ago that plants ben...
- Combined linkage and association mapping reveals CYCD5;1 as a quantitative trait gene for endoreduplication in Arabidopsis
[作者:Sterken, R; Kiekens, R; Boruc, J; Zhang, FH; Vercauteren, A; Vercauteren, I; De Smet, L; Dhondt, S; Inze, D; De Veylder, L; Russinova, E; Vuylsteke, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4678-4683 , 文章类型: Article,,卷期:2012年109-12]
- Endoreduplication is the process where a cell replicates its genome without mitosis and cytokinesis, often followed by cell differentiation. This alternative cell cycle results in various levels of endoploidy, reaching 4...
- Salience network integrity predicts default mode network function after traumatic brain injury
[作者:Bonnelle, V; Ham, TE; Leech, R; Kinnunen, KM; Mehta, MA; Greenwood, RJ; Sharp, DJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4690-4695 , 文章类型: Article,,卷期:2012年109-12]
- Efficient behavior involves the coordinated activity of large-scale brain networks, but the way in which these networks interact is uncertain. One theory is that the salience network (SN)-which includes the anterior cing...
- On a fundamental structure of gene networks in living cells
[作者:Kravchenko-Balasha, N; Levitzki, A; Goldstein, A; Rotter, V; Gross, A; Remacle, F; Levine, RD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4702-4707 , 文章类型: Article,,卷期:2012年109-12]
- Computers are organized into hardware and software. Using a theoretical approach to identify patterns in gene expression in a variety of species, organs, and cell types, we found that biological systems similarly are com...
- Silencing of parathyroid hormone (PTH) receptor 1 in T cells blunts the bone anabolic activity of PTH
[作者:Bedi, B; Li, JY; Tawfeek, H; Baek, KH; Adams, J; Vangara, SS; Chang, MK; Kneissel, M; Weitzmanna, MN; Pacifici, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E725-E733 , 文章类型: Article,,卷期:2012年109-12]
- Intermittent parathyroid hormone (iPTH) treatment stimulates T-cell production of the osteogenic Wnt ligand Wnt10b, a factor required for iPTH to activate Wnt signaling in osteoblasts and stimulate bone formation. Howeve...
- Evidence for an intermediate conformational state of LacY
[作者:Jiang, XX; Guan, L; Zhou, YG; Hong, WX; Zhang, QH; Kaback, HR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E698-E704 , 文章类型: Article,,卷期:2012年109-12]
- LacY mutant Cys154 --> Gly exhibits a periplasmic-closed crystal structure identical to the WT, but is periplasmic-open in the membrane. The mutant hardly catalyzes transport, but binds galactosides from either side of t...
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